Chronobiology of bipolar affective disorder: a narrative review

• Autor(a) principal: Silva , Breno Márcio Bottino de Melo
• Data de Publicação: 2022
• Outros Autores: Vieira, Júlia Ferreira, Sousa, Thais Bruna Melo, Souza, José Carlos Pires
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Debates em Psiquiatria (Online)
• Texto Completo: https://revistardp.org.br/revista/article/view/288
• topic: cronobiologia; transtorno bipolar; sono; psiquiatria; chronobiology; bipolar disorder; sleep; psychiatry; cronobiologia; trastorno bipolar; sueño; psiquiatría

The purpose of this article is to discuss the direct relationship between chronobiology and Bipolar Affective Disorder (BAD), and how chronobiology interferes in BAD, emphasizing the circadian alterations of its patients, as well as the need to value chronobiological knowledge for a global and evidence-based treatment. A narrative bibliographic review was carried out, in which the National Library of Medicine (Pubmed), Scientific Electronic Library Online (Scielo), Latin American and Caribbean Literature on Health Sciences (Lilacs) and "Google Scholar” were used to search for articles. Articles published in English, Portuguese and Spanish published in the last decade, between 2011 and 2021, were included. The results show that, in cases of mental health and psychiatry, specifically BAD, a seasonal and cyclical influence is perceived in circadian variables, such as cortisol and other hormones, body temperature, levels of neutrophils and other white cells that act directly on the immune system, on the pathophysiology and natural history of this disease. Having knowledge about the chronobiology of BAD provides the physician with a multidisciplinary and complete approach to the care that the affected patient needs.