Insights into compulsive eating behavior, body image, and inflammation among individuals with schizophrenia

• Autor(a) principal: Amato, Isabel de Andrade
• Data de Publicação: 2023
• Outros Autores: Silva , Renato Oliveira, Lorencetti , Pedro Gabriel, Vicentin, Sérgio Roberto Correa, Prado, Thaís Paulino do, Bobbo, Vanessa Cristina, Nogueira, Guilherme Augusto da Silva, Celeri, Eloisa Helena Rubello Valler, Azevedo, Renata Cruz Soares de, Velloso, Lício Augusto, Dalgalarrondo, Paulo, Santos Junior, Amilton dos
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Debates em Psiquiatria (Online)
• Texto Completo: https://revistardp.org.br/revista/article/view/832
• topic: Transtorno da Compulsão Alimentar; Inflamação; Esquizofrenia; Insatisfação Corporal; Binge-Eating Disorder; Inflammation; Schizophrenia; Body Dissatisfaction; Inflamación; Esquizofrenia; Insatisfacción Corporal; conducta alimentaria compulsiva

Objective: Binge Eating Disorder (BED) is highly prevalent in individuals with schizophrenia. This study aimed to explore the perception of compulsive eating in patients with schizophrenia and its associations with clinical, psychopathological, and inflammatory markers. Methods: 45 participants with a complaint of binge eating were assessed using the Binge Eating Scale (BES). Clinical and anthropometric assessments were performed, which included body fat measurements, as well as psychopathological dimension measurements using the Positive and Negative Symptom Scale (PANSS). In addition, a body image satisfaction questionnaire based on items from the Body Shape Satisfaction Scale (BSSS) and the Body Shape Questionnaire (BSQ) was administered. Serum inflammatory marker analyses were also conducted, which included the measurement of IL-1β, IL-6, IL-10, TNF-α, and leptin. Results: Spearman correlation tests revealed positive correlations between BES scores, body image dissatisfaction, and PANSS score, as well as a negative correlation with IL-10. Multiple linear regression models showed that BES scores, although not sufficient for the diagnosis of binge eating, were positively associated with body image dissatisfaction score, IL-1β, IL-6 levels (both proinflammatory cytokines), and negatively with IL-10 (an anti-inflammatory cytokine). Conclusion: Our findings suggest that chronic inflammation and psychopathology in individuals with schizophrenia may be associated with impulsive eating behaviors and poorer body image perception. In addition to inflammation, binge eating may contribute to increased cardiovascular mortality and worsening health status of these patients.