Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug delivery
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Polímeros (São Carlos. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400406 |
Resumo: | Abstract Anacardic Acid (AA) and Cardol (CD) are the main constituents of the cashew nut shell liquid, which presented several biological activities. In this study, a 23 factorial experimental design was employed in order to evaluate the influence of the reaction conditions in the nanoencapsulation of AA and CD using Chitosan (CH), Alginate (ALG) and Arabic Gum matrices. The nanoparticles (NPs) with higher stability and encapsulation efficiency were those with ALG as an outer coating and with lower content of surfactant. The NPs presented nanometric size with 90% of the distribution ranging from 70 to 250 nm. The in vitro kinetics revealed that CH-ALG/AA and CH-ALG/CD NPs followed zero-order kinetics model, showing a significantly slow release rate, with values of 33% and 63%, respectively, after 240h. Particularly, CH-ALG/CD NPs presented higher inhibitory capacity for all strains of dermatophytes due to their release rate, with promising results for antimicrobial control. |
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Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug deliveryanacardic acidcardoldrug deliverychitosannanomaterialsAbstract Anacardic Acid (AA) and Cardol (CD) are the main constituents of the cashew nut shell liquid, which presented several biological activities. In this study, a 23 factorial experimental design was employed in order to evaluate the influence of the reaction conditions in the nanoencapsulation of AA and CD using Chitosan (CH), Alginate (ALG) and Arabic Gum matrices. The nanoparticles (NPs) with higher stability and encapsulation efficiency were those with ALG as an outer coating and with lower content of surfactant. The NPs presented nanometric size with 90% of the distribution ranging from 70 to 250 nm. The in vitro kinetics revealed that CH-ALG/AA and CH-ALG/CD NPs followed zero-order kinetics model, showing a significantly slow release rate, with values of 33% and 63%, respectively, after 240h. Particularly, CH-ALG/CD NPs presented higher inhibitory capacity for all strains of dermatophytes due to their release rate, with promising results for antimicrobial control.Associação Brasileira de Polímeros2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400406Polímeros v.29 n.4 2019reponame:Polímeros (São Carlos. Online)instname:Associação Brasileira de Polímeros (ABPol)instacron:ABPO10.1590/0104-1428.08118info:eu-repo/semantics/openAccessPaiva Filho,João CamposMorais,Selene Maia deNogueira Sobrinho,Antonio CarlosCavalcante,Gessica SoaresSilva,Nilvan Alves daAbreu,Flávia Oliveira Monteiro da Silvaeng2020-04-23T00:00:00Zoai:scielo:S0104-14282019000400406Revistahttp://www.scielo.br/pohttps://old.scielo.br/oai/scielo-oai.php||revista@abpol.org.br1678-51690104-1428opendoar:2020-04-23T00:00Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)false |
dc.title.none.fl_str_mv |
Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug delivery |
title |
Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug delivery |
spellingShingle |
Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug delivery Paiva Filho,João Campos anacardic acid cardol drug delivery chitosan nanomaterials |
title_short |
Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug delivery |
title_full |
Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug delivery |
title_fullStr |
Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug delivery |
title_full_unstemmed |
Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug delivery |
title_sort |
Design of chitosan-alginate core-shell nanoparticules loaded with anacardic acid and cardol for drug delivery |
author |
Paiva Filho,João Campos |
author_facet |
Paiva Filho,João Campos Morais,Selene Maia de Nogueira Sobrinho,Antonio Carlos Cavalcante,Gessica Soares Silva,Nilvan Alves da Abreu,Flávia Oliveira Monteiro da Silva |
author_role |
author |
author2 |
Morais,Selene Maia de Nogueira Sobrinho,Antonio Carlos Cavalcante,Gessica Soares Silva,Nilvan Alves da Abreu,Flávia Oliveira Monteiro da Silva |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Paiva Filho,João Campos Morais,Selene Maia de Nogueira Sobrinho,Antonio Carlos Cavalcante,Gessica Soares Silva,Nilvan Alves da Abreu,Flávia Oliveira Monteiro da Silva |
dc.subject.por.fl_str_mv |
anacardic acid cardol drug delivery chitosan nanomaterials |
topic |
anacardic acid cardol drug delivery chitosan nanomaterials |
description |
Abstract Anacardic Acid (AA) and Cardol (CD) are the main constituents of the cashew nut shell liquid, which presented several biological activities. In this study, a 23 factorial experimental design was employed in order to evaluate the influence of the reaction conditions in the nanoencapsulation of AA and CD using Chitosan (CH), Alginate (ALG) and Arabic Gum matrices. The nanoparticles (NPs) with higher stability and encapsulation efficiency were those with ALG as an outer coating and with lower content of surfactant. The NPs presented nanometric size with 90% of the distribution ranging from 70 to 250 nm. The in vitro kinetics revealed that CH-ALG/AA and CH-ALG/CD NPs followed zero-order kinetics model, showing a significantly slow release rate, with values of 33% and 63%, respectively, after 240h. Particularly, CH-ALG/CD NPs presented higher inhibitory capacity for all strains of dermatophytes due to their release rate, with promising results for antimicrobial control. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400406 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400406 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0104-1428.08118 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Polímeros |
publisher.none.fl_str_mv |
Associação Brasileira de Polímeros |
dc.source.none.fl_str_mv |
Polímeros v.29 n.4 2019 reponame:Polímeros (São Carlos. Online) instname:Associação Brasileira de Polímeros (ABPol) instacron:ABPO |
instname_str |
Associação Brasileira de Polímeros (ABPol) |
instacron_str |
ABPO |
institution |
ABPO |
reponame_str |
Polímeros (São Carlos. Online) |
collection |
Polímeros (São Carlos. Online) |
repository.name.fl_str_mv |
Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol) |
repository.mail.fl_str_mv |
||revista@abpol.org.br |
_version_ |
1754212590935867392 |