The potential of chitosan for pulmonary drug delivery

Detalhes bibliográficos
Autor(a) principal: Grenha, Ana
Data de Publicação: 2010
Outros Autores: Al-Qadi, Sonia, Seijo, Begoña, Remuñán-López, Carmen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/2098
Resumo: The administration of drugs through the pulmonary route offers great advantages, but also requires overcoming many challenges. There is a need to develop appropriate carriers for each active molecule to be delivered to the desired site in the lung, either for a local or a systemic effect. The polysaccharide chitosan is a very promising material for this purpose, given its demonstrated properties of biodegradability and biocompatibility, as well as mucoadhesivity and ability to enhance macromolecules permeation. In this review, the potential of chitosan to develop drug carriers for delivery to the lung will be discussed. The most important features that can support its selection will be explained. Besides, different approaches to increase its performance, especially concerning solubility, permeation-enhancing properties and gene transfection efficiency, will be presented. Special emphasis will be placed on information of different chitosan-based carriers, namely nanoparticles and microparticles, intended for pulmonary drug delivery.
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spelling The potential of chitosan for pulmonary drug deliveryChitosanGene deliveryMicrospheresNanoparticlesLung deliveryThe administration of drugs through the pulmonary route offers great advantages, but also requires overcoming many challenges. There is a need to develop appropriate carriers for each active molecule to be delivered to the desired site in the lung, either for a local or a systemic effect. The polysaccharide chitosan is a very promising material for this purpose, given its demonstrated properties of biodegradability and biocompatibility, as well as mucoadhesivity and ability to enhance macromolecules permeation. In this review, the potential of chitosan to develop drug carriers for delivery to the lung will be discussed. The most important features that can support its selection will be explained. Besides, different approaches to increase its performance, especially concerning solubility, permeation-enhancing properties and gene transfection efficiency, will be presented. Special emphasis will be placed on information of different chitosan-based carriers, namely nanoparticles and microparticles, intended for pulmonary drug delivery.SapientiaGrenha, AnaAl-Qadi, SoniaSeijo, BegoñaRemuñán-López, Carmen2013-01-16T13:35:56Z20102010-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/2098eng1773-2247AUT: AMG02212;info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:13:10Zoai:sapientia.ualg.pt:10400.1/2098Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:56:03.682840Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The potential of chitosan for pulmonary drug delivery
title The potential of chitosan for pulmonary drug delivery
spellingShingle The potential of chitosan for pulmonary drug delivery
Grenha, Ana
Chitosan
Gene delivery
Microspheres
Nanoparticles
Lung delivery
title_short The potential of chitosan for pulmonary drug delivery
title_full The potential of chitosan for pulmonary drug delivery
title_fullStr The potential of chitosan for pulmonary drug delivery
title_full_unstemmed The potential of chitosan for pulmonary drug delivery
title_sort The potential of chitosan for pulmonary drug delivery
author Grenha, Ana
author_facet Grenha, Ana
Al-Qadi, Sonia
Seijo, Begoña
Remuñán-López, Carmen
author_role author
author2 Al-Qadi, Sonia
Seijo, Begoña
Remuñán-López, Carmen
author2_role author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Grenha, Ana
Al-Qadi, Sonia
Seijo, Begoña
Remuñán-López, Carmen
dc.subject.por.fl_str_mv Chitosan
Gene delivery
Microspheres
Nanoparticles
Lung delivery
topic Chitosan
Gene delivery
Microspheres
Nanoparticles
Lung delivery
description The administration of drugs through the pulmonary route offers great advantages, but also requires overcoming many challenges. There is a need to develop appropriate carriers for each active molecule to be delivered to the desired site in the lung, either for a local or a systemic effect. The polysaccharide chitosan is a very promising material for this purpose, given its demonstrated properties of biodegradability and biocompatibility, as well as mucoadhesivity and ability to enhance macromolecules permeation. In this review, the potential of chitosan to develop drug carriers for delivery to the lung will be discussed. The most important features that can support its selection will be explained. Besides, different approaches to increase its performance, especially concerning solubility, permeation-enhancing properties and gene transfection efficiency, will be presented. Special emphasis will be placed on information of different chitosan-based carriers, namely nanoparticles and microparticles, intended for pulmonary drug delivery.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01T00:00:00Z
2013-01-16T13:35:56Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/2098
url http://hdl.handle.net/10400.1/2098
dc.language.iso.fl_str_mv eng
language eng
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AUT: AMG02212;
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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