Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol

• Autor(a) principal: Iida,Aline Sayuri Lima
• Data de Publicação: 2019
• Outros Autores: Luz,Karina Novais, Barros-Alexandrino,Taís Téo, Fávaro-Trindade,Carmen Sílvia, Pinho,Samantha Cristina de, Assis,Odílio Benedito Garrido, Martelli-Tosi,Milena
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Polímeros (São Carlos. Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400402
• topic: liposomes; cholecalciferol; lecithin; encapsulation; vitamin stability

Abstract Tripolyphosphate (TPP)-chitosomes were produced aiming at the encapsulation and conservation of vitamin D3. This hybrid system is made of liposomes, vesicles consisting of phospholipid bilayers, surrounded by chitosan wall ionic-crosslinked with TPP. Chitosan concentrations (2 and 4 mg mL-1) were tested and the vitamin stability in aqueous dispersions monitored for 49 days. The results confim that D3 remained stable throughout the analyzed period (49 days), whereas the non-encapsulated vitamin totally degrades after the second week of storage. The particle diameters ranged from 0.1 to 5 μm with good colloidal stability (+22 to +48 mV), and encapsulation efficiency of 97%. Thermal stability was also improved when using the TPP-chitosomes. The protection performed was attributed to the stable interactions conferred by the phospholipids crosslinking with the chitosan amino groups and a formation of a net of hydrogen bonds established amongst the hydroxyl groups of the interacting compounds as revealed by infrared spectroscopy.