Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Polímeros (São Carlos. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400402 |
Resumo: | Abstract Tripolyphosphate (TPP)-chitosomes were produced aiming at the encapsulation and conservation of vitamin D3. This hybrid system is made of liposomes, vesicles consisting of phospholipid bilayers, surrounded by chitosan wall ionic-crosslinked with TPP. Chitosan concentrations (2 and 4 mg mL-1) were tested and the vitamin stability in aqueous dispersions monitored for 49 days. The results confim that D3 remained stable throughout the analyzed period (49 days), whereas the non-encapsulated vitamin totally degrades after the second week of storage. The particle diameters ranged from 0.1 to 5 μm with good colloidal stability (+22 to +48 mV), and encapsulation efficiency of 97%. Thermal stability was also improved when using the TPP-chitosomes. The protection performed was attributed to the stable interactions conferred by the phospholipids crosslinking with the chitosan amino groups and a formation of a net of hydrogen bonds established amongst the hydroxyl groups of the interacting compounds as revealed by infrared spectroscopy. |
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Polímeros (São Carlos. Online) |
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Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferolliposomescholecalciferollecithinencapsulationvitamin stabilityAbstract Tripolyphosphate (TPP)-chitosomes were produced aiming at the encapsulation and conservation of vitamin D3. This hybrid system is made of liposomes, vesicles consisting of phospholipid bilayers, surrounded by chitosan wall ionic-crosslinked with TPP. Chitosan concentrations (2 and 4 mg mL-1) were tested and the vitamin stability in aqueous dispersions monitored for 49 days. The results confim that D3 remained stable throughout the analyzed period (49 days), whereas the non-encapsulated vitamin totally degrades after the second week of storage. The particle diameters ranged from 0.1 to 5 μm with good colloidal stability (+22 to +48 mV), and encapsulation efficiency of 97%. Thermal stability was also improved when using the TPP-chitosomes. The protection performed was attributed to the stable interactions conferred by the phospholipids crosslinking with the chitosan amino groups and a formation of a net of hydrogen bonds established amongst the hydroxyl groups of the interacting compounds as revealed by infrared spectroscopy.Associação Brasileira de Polímeros2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400402Polímeros v.29 n.4 2019reponame:Polímeros (São Carlos. Online)instname:Associação Brasileira de Polímeros (ABPol)instacron:ABPO10.1590/0104-1428.04119info:eu-repo/semantics/openAccessIida,Aline Sayuri LimaLuz,Karina NovaisBarros-Alexandrino,Taís TéoFávaro-Trindade,Carmen SílviaPinho,Samantha Cristina deAssis,Odílio Benedito GarridoMartelli-Tosi,Milenaeng2020-04-03T00:00:00Zoai:scielo:S0104-14282019000400402Revistahttp://www.scielo.br/pohttps://old.scielo.br/oai/scielo-oai.php||revista@abpol.org.br1678-51690104-1428opendoar:2020-04-03T00:00Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)false |
dc.title.none.fl_str_mv |
Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol |
title |
Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol |
spellingShingle |
Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol Iida,Aline Sayuri Lima liposomes cholecalciferol lecithin encapsulation vitamin stability |
title_short |
Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol |
title_full |
Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol |
title_fullStr |
Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol |
title_full_unstemmed |
Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol |
title_sort |
Investigation of TPP-Chitosomes particles structure and stability as encapsulating agent of cholecalciferol |
author |
Iida,Aline Sayuri Lima |
author_facet |
Iida,Aline Sayuri Lima Luz,Karina Novais Barros-Alexandrino,Taís Téo Fávaro-Trindade,Carmen Sílvia Pinho,Samantha Cristina de Assis,Odílio Benedito Garrido Martelli-Tosi,Milena |
author_role |
author |
author2 |
Luz,Karina Novais Barros-Alexandrino,Taís Téo Fávaro-Trindade,Carmen Sílvia Pinho,Samantha Cristina de Assis,Odílio Benedito Garrido Martelli-Tosi,Milena |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Iida,Aline Sayuri Lima Luz,Karina Novais Barros-Alexandrino,Taís Téo Fávaro-Trindade,Carmen Sílvia Pinho,Samantha Cristina de Assis,Odílio Benedito Garrido Martelli-Tosi,Milena |
dc.subject.por.fl_str_mv |
liposomes cholecalciferol lecithin encapsulation vitamin stability |
topic |
liposomes cholecalciferol lecithin encapsulation vitamin stability |
description |
Abstract Tripolyphosphate (TPP)-chitosomes were produced aiming at the encapsulation and conservation of vitamin D3. This hybrid system is made of liposomes, vesicles consisting of phospholipid bilayers, surrounded by chitosan wall ionic-crosslinked with TPP. Chitosan concentrations (2 and 4 mg mL-1) were tested and the vitamin stability in aqueous dispersions monitored for 49 days. The results confim that D3 remained stable throughout the analyzed period (49 days), whereas the non-encapsulated vitamin totally degrades after the second week of storage. The particle diameters ranged from 0.1 to 5 μm with good colloidal stability (+22 to +48 mV), and encapsulation efficiency of 97%. Thermal stability was also improved when using the TPP-chitosomes. The protection performed was attributed to the stable interactions conferred by the phospholipids crosslinking with the chitosan amino groups and a formation of a net of hydrogen bonds established amongst the hydroxyl groups of the interacting compounds as revealed by infrared spectroscopy. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400402 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400402 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0104-1428.04119 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Polímeros |
publisher.none.fl_str_mv |
Associação Brasileira de Polímeros |
dc.source.none.fl_str_mv |
Polímeros v.29 n.4 2019 reponame:Polímeros (São Carlos. Online) instname:Associação Brasileira de Polímeros (ABPol) instacron:ABPO |
instname_str |
Associação Brasileira de Polímeros (ABPol) |
instacron_str |
ABPO |
institution |
ABPO |
reponame_str |
Polímeros (São Carlos. Online) |
collection |
Polímeros (São Carlos. Online) |
repository.name.fl_str_mv |
Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol) |
repository.mail.fl_str_mv |
||revista@abpol.org.br |
_version_ |
1754212590926430208 |