Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizide

Detalhes bibliográficos
Autor(a) principal: Gayathri,Dhanasekaran
Data de Publicação: 2019
Outros Autores: Jayakumari,Lakshmanan Saraswathy
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Polímeros (São Carlos. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400414
Resumo: Abstract In the present work, commercial arrowroot starch (AR starch) has been successfully used as a base material with sodium salt of carboxy methyl cellulose (CMC) for buccal drug delivery system. Different ratio of CMC and AR starch has been prepared with constant ratio of drug. In our study, glipizide has been used as the drug for controlled drug delivery through buccal mucosa. Films were cast by solution casting method with glycerol as plasticizer. All the films were characterized for thickness, swelling index, moisture content, relative pH, drug content uniformity, compatibility of polymer and drug, surface morphology of films, muco adhesive property and in-vitro drug release study. Formulation F3 shows a residence time of 140 minutes with good mucoadhesive property, compatibility within polymers, drug content uniformity of 100 ± 6.0% and a controlled drug release among all the ratios.
id ABPO-1_93892d619ba49f13bdf8e73901a9448d
oai_identifier_str oai:scielo:S0104-14282019000400414
network_acronym_str ABPO-1
network_name_str Polímeros (São Carlos. Online)
repository_id_str
spelling Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizidearrowroot starchbuccal drug deliveryCMCfilmglipizideAbstract In the present work, commercial arrowroot starch (AR starch) has been successfully used as a base material with sodium salt of carboxy methyl cellulose (CMC) for buccal drug delivery system. Different ratio of CMC and AR starch has been prepared with constant ratio of drug. In our study, glipizide has been used as the drug for controlled drug delivery through buccal mucosa. Films were cast by solution casting method with glycerol as plasticizer. All the films were characterized for thickness, swelling index, moisture content, relative pH, drug content uniformity, compatibility of polymer and drug, surface morphology of films, muco adhesive property and in-vitro drug release study. Formulation F3 shows a residence time of 140 minutes with good mucoadhesive property, compatibility within polymers, drug content uniformity of 100 ± 6.0% and a controlled drug release among all the ratios.Associação Brasileira de Polímeros2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400414Polímeros v.29 n.4 2019reponame:Polímeros (São Carlos. Online)instname:Associação Brasileira de Polímeros (ABPol)instacron:ABPO10.1590/0104-1428.06619info:eu-repo/semantics/openAccessGayathri,DhanasekaranJayakumari,Lakshmanan Saraswathyeng2020-04-23T00:00:00Zoai:scielo:S0104-14282019000400414Revistahttp://www.scielo.br/pohttps://old.scielo.br/oai/scielo-oai.php||revista@abpol.org.br1678-51690104-1428opendoar:2020-04-23T00:00Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)false
dc.title.none.fl_str_mv Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizide
title Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizide
spellingShingle Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizide
Gayathri,Dhanasekaran
arrowroot starch
buccal drug delivery
CMC
film
glipizide
title_short Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizide
title_full Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizide
title_fullStr Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizide
title_full_unstemmed Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizide
title_sort Evaluation of commercial arrowroot starch/CMC film for buccal drug delivery of glipizide
author Gayathri,Dhanasekaran
author_facet Gayathri,Dhanasekaran
Jayakumari,Lakshmanan Saraswathy
author_role author
author2 Jayakumari,Lakshmanan Saraswathy
author2_role author
dc.contributor.author.fl_str_mv Gayathri,Dhanasekaran
Jayakumari,Lakshmanan Saraswathy
dc.subject.por.fl_str_mv arrowroot starch
buccal drug delivery
CMC
film
glipizide
topic arrowroot starch
buccal drug delivery
CMC
film
glipizide
description Abstract In the present work, commercial arrowroot starch (AR starch) has been successfully used as a base material with sodium salt of carboxy methyl cellulose (CMC) for buccal drug delivery system. Different ratio of CMC and AR starch has been prepared with constant ratio of drug. In our study, glipizide has been used as the drug for controlled drug delivery through buccal mucosa. Films were cast by solution casting method with glycerol as plasticizer. All the films were characterized for thickness, swelling index, moisture content, relative pH, drug content uniformity, compatibility of polymer and drug, surface morphology of films, muco adhesive property and in-vitro drug release study. Formulation F3 shows a residence time of 140 minutes with good mucoadhesive property, compatibility within polymers, drug content uniformity of 100 ± 6.0% and a controlled drug release among all the ratios.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400414
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282019000400414
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0104-1428.06619
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Polímeros
publisher.none.fl_str_mv Associação Brasileira de Polímeros
dc.source.none.fl_str_mv Polímeros v.29 n.4 2019
reponame:Polímeros (São Carlos. Online)
instname:Associação Brasileira de Polímeros (ABPol)
instacron:ABPO
instname_str Associação Brasileira de Polímeros (ABPol)
instacron_str ABPO
institution ABPO
reponame_str Polímeros (São Carlos. Online)
collection Polímeros (São Carlos. Online)
repository.name.fl_str_mv Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)
repository.mail.fl_str_mv ||revista@abpol.org.br
_version_ 1754212590953693184

Registros relacionados