Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications

Detalhes bibliográficos
Autor(a) principal: Silva,Loise Silveira da
Data de Publicação: 2020
Outros Autores: Gindri,Izabelle de Mello, Salmoria,Gean Vitor, Roesler,Carlos Rodrigo de Mello
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Polímeros (São Carlos. Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000300411
Resumo: Abstract In this study, the preparation of a novel functional material for orthopedic implants using compression molding was investigated. The new functional material is envisioned to avoid inflammatory reactions in vivo after prosthesis implantation. Ibuprofen-loaded UHMWPE samples were prepared in two concentrations (3% and 5%) and samples were characterized in terms of physicochemical and mechanical properties. In addition, the drug-release profile was investigated. The manufacturing process resulted in a homogeneous polymer matrix with homogeneous drug dispersion. The addition of ibuprofen had a minor effect on physicochemical properties but a more significant influence on the mechanical behavior of the specimens was observed. Drug release was demonstrated and overall the results obtained showed a positive outcome with regard to the intended use. The properties analyzed remained within an acceptable range for medical application and the drug-release profile obtained for the material developed shows promise for its use as an anti-inflammatory system.
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spelling Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applicationsUHMWPEibuprofenbiomaterialdrug deliveryorthopedic implantsmaterial characterizationAbstract In this study, the preparation of a novel functional material for orthopedic implants using compression molding was investigated. The new functional material is envisioned to avoid inflammatory reactions in vivo after prosthesis implantation. Ibuprofen-loaded UHMWPE samples were prepared in two concentrations (3% and 5%) and samples were characterized in terms of physicochemical and mechanical properties. In addition, the drug-release profile was investigated. The manufacturing process resulted in a homogeneous polymer matrix with homogeneous drug dispersion. The addition of ibuprofen had a minor effect on physicochemical properties but a more significant influence on the mechanical behavior of the specimens was observed. Drug release was demonstrated and overall the results obtained showed a positive outcome with regard to the intended use. The properties analyzed remained within an acceptable range for medical application and the drug-release profile obtained for the material developed shows promise for its use as an anti-inflammatory system.Associação Brasileira de Polímeros2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000300411Polímeros v.30 n.3 2020reponame:Polímeros (São Carlos. Online)instname:Associação Brasileira de Polímeros (ABPol)instacron:ABPO10.1590/0104-1428.04220info:eu-repo/semantics/openAccessSilva,Loise Silveira daGindri,Izabelle de MelloSalmoria,Gean VitorRoesler,Carlos Rodrigo de Melloeng2021-02-19T00:00:00Zoai:scielo:S0104-14282020000300411Revistahttp://www.scielo.br/pohttps://old.scielo.br/oai/scielo-oai.php||revista@abpol.org.br1678-51690104-1428opendoar:2021-02-19T00:00Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)false
dc.title.none.fl_str_mv Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications
title Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications
spellingShingle Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications
Silva,Loise Silveira da
UHMWPE
ibuprofen
biomaterial
drug delivery
orthopedic implants
material characterization
title_short Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications
title_full Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications
title_fullStr Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications
title_full_unstemmed Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications
title_sort Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications
author Silva,Loise Silveira da
author_facet Silva,Loise Silveira da
Gindri,Izabelle de Mello
Salmoria,Gean Vitor
Roesler,Carlos Rodrigo de Mello
author_role author
author2 Gindri,Izabelle de Mello
Salmoria,Gean Vitor
Roesler,Carlos Rodrigo de Mello
author2_role author
author
author
dc.contributor.author.fl_str_mv Silva,Loise Silveira da
Gindri,Izabelle de Mello
Salmoria,Gean Vitor
Roesler,Carlos Rodrigo de Mello
dc.subject.por.fl_str_mv UHMWPE
ibuprofen
biomaterial
drug delivery
orthopedic implants
material characterization
topic UHMWPE
ibuprofen
biomaterial
drug delivery
orthopedic implants
material characterization
description Abstract In this study, the preparation of a novel functional material for orthopedic implants using compression molding was investigated. The new functional material is envisioned to avoid inflammatory reactions in vivo after prosthesis implantation. Ibuprofen-loaded UHMWPE samples were prepared in two concentrations (3% and 5%) and samples were characterized in terms of physicochemical and mechanical properties. In addition, the drug-release profile was investigated. The manufacturing process resulted in a homogeneous polymer matrix with homogeneous drug dispersion. The addition of ibuprofen had a minor effect on physicochemical properties but a more significant influence on the mechanical behavior of the specimens was observed. Drug release was demonstrated and overall the results obtained showed a positive outcome with regard to the intended use. The properties analyzed remained within an acceptable range for medical application and the drug-release profile obtained for the material developed shows promise for its use as an anti-inflammatory system.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000300411
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000300411
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0104-1428.04220
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Polímeros
publisher.none.fl_str_mv Associação Brasileira de Polímeros
dc.source.none.fl_str_mv Polímeros v.30 n.3 2020
reponame:Polímeros (São Carlos. Online)
instname:Associação Brasileira de Polímeros (ABPol)
instacron:ABPO
instname_str Associação Brasileira de Polímeros (ABPol)
instacron_str ABPO
institution ABPO
reponame_str Polímeros (São Carlos. Online)
collection Polímeros (São Carlos. Online)
repository.name.fl_str_mv Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)
repository.mail.fl_str_mv ||revista@abpol.org.br
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