Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Polímeros (São Carlos. Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000300411 |
Resumo: | Abstract In this study, the preparation of a novel functional material for orthopedic implants using compression molding was investigated. The new functional material is envisioned to avoid inflammatory reactions in vivo after prosthesis implantation. Ibuprofen-loaded UHMWPE samples were prepared in two concentrations (3% and 5%) and samples were characterized in terms of physicochemical and mechanical properties. In addition, the drug-release profile was investigated. The manufacturing process resulted in a homogeneous polymer matrix with homogeneous drug dispersion. The addition of ibuprofen had a minor effect on physicochemical properties but a more significant influence on the mechanical behavior of the specimens was observed. Drug release was demonstrated and overall the results obtained showed a positive outcome with regard to the intended use. The properties analyzed remained within an acceptable range for medical application and the drug-release profile obtained for the material developed shows promise for its use as an anti-inflammatory system. |
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Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applicationsUHMWPEibuprofenbiomaterialdrug deliveryorthopedic implantsmaterial characterizationAbstract In this study, the preparation of a novel functional material for orthopedic implants using compression molding was investigated. The new functional material is envisioned to avoid inflammatory reactions in vivo after prosthesis implantation. Ibuprofen-loaded UHMWPE samples were prepared in two concentrations (3% and 5%) and samples were characterized in terms of physicochemical and mechanical properties. In addition, the drug-release profile was investigated. The manufacturing process resulted in a homogeneous polymer matrix with homogeneous drug dispersion. The addition of ibuprofen had a minor effect on physicochemical properties but a more significant influence on the mechanical behavior of the specimens was observed. Drug release was demonstrated and overall the results obtained showed a positive outcome with regard to the intended use. The properties analyzed remained within an acceptable range for medical application and the drug-release profile obtained for the material developed shows promise for its use as an anti-inflammatory system.Associação Brasileira de Polímeros2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000300411Polímeros v.30 n.3 2020reponame:Polímeros (São Carlos. Online)instname:Associação Brasileira de Polímeros (ABPol)instacron:ABPO10.1590/0104-1428.04220info:eu-repo/semantics/openAccessSilva,Loise Silveira daGindri,Izabelle de MelloSalmoria,Gean VitorRoesler,Carlos Rodrigo de Melloeng2021-02-19T00:00:00Zoai:scielo:S0104-14282020000300411Revistahttp://www.scielo.br/pohttps://old.scielo.br/oai/scielo-oai.php||revista@abpol.org.br1678-51690104-1428opendoar:2021-02-19T00:00Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol)false |
dc.title.none.fl_str_mv |
Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications |
title |
Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications |
spellingShingle |
Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications Silva,Loise Silveira da UHMWPE ibuprofen biomaterial drug delivery orthopedic implants material characterization |
title_short |
Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications |
title_full |
Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications |
title_fullStr |
Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications |
title_full_unstemmed |
Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications |
title_sort |
Physicochemical characterization, drug release and mechanical analysis of ibuprofen-loaded uhmwpe for orthopedic applications |
author |
Silva,Loise Silveira da |
author_facet |
Silva,Loise Silveira da Gindri,Izabelle de Mello Salmoria,Gean Vitor Roesler,Carlos Rodrigo de Mello |
author_role |
author |
author2 |
Gindri,Izabelle de Mello Salmoria,Gean Vitor Roesler,Carlos Rodrigo de Mello |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva,Loise Silveira da Gindri,Izabelle de Mello Salmoria,Gean Vitor Roesler,Carlos Rodrigo de Mello |
dc.subject.por.fl_str_mv |
UHMWPE ibuprofen biomaterial drug delivery orthopedic implants material characterization |
topic |
UHMWPE ibuprofen biomaterial drug delivery orthopedic implants material characterization |
description |
Abstract In this study, the preparation of a novel functional material for orthopedic implants using compression molding was investigated. The new functional material is envisioned to avoid inflammatory reactions in vivo after prosthesis implantation. Ibuprofen-loaded UHMWPE samples were prepared in two concentrations (3% and 5%) and samples were characterized in terms of physicochemical and mechanical properties. In addition, the drug-release profile was investigated. The manufacturing process resulted in a homogeneous polymer matrix with homogeneous drug dispersion. The addition of ibuprofen had a minor effect on physicochemical properties but a more significant influence on the mechanical behavior of the specimens was observed. Drug release was demonstrated and overall the results obtained showed a positive outcome with regard to the intended use. The properties analyzed remained within an acceptable range for medical application and the drug-release profile obtained for the material developed shows promise for its use as an anti-inflammatory system. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000300411 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-14282020000300411 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0104-1428.04220 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Polímeros |
publisher.none.fl_str_mv |
Associação Brasileira de Polímeros |
dc.source.none.fl_str_mv |
Polímeros v.30 n.3 2020 reponame:Polímeros (São Carlos. Online) instname:Associação Brasileira de Polímeros (ABPol) instacron:ABPO |
instname_str |
Associação Brasileira de Polímeros (ABPol) |
instacron_str |
ABPO |
institution |
ABPO |
reponame_str |
Polímeros (São Carlos. Online) |
collection |
Polímeros (São Carlos. Online) |
repository.name.fl_str_mv |
Polímeros (São Carlos. Online) - Associação Brasileira de Polímeros (ABPol) |
repository.mail.fl_str_mv |
||revista@abpol.org.br |
_version_ |
1754212591272460288 |