Interference from circadian disruption on bone homeostasis

• Autor(a) principal: Contini, André Scarpel
• Data de Publicação: 2021
• Outros Autores: Souza, Mário Silveira, Deliyannis, Ariadne
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Aesthetic Orofacial Science
• Texto Completo: https://ahof.emnuvens.com.br/ahof/article/view/39
• topic: Ciclo circadiano; Metabolismo ósseo; Implantodontia; Periodontia; Odontologia biológica; Circadian cycle; bone metabolism; implantology; periodontics; biological dentistry; ciclo circadiano; metabolismo óseo; implantología; periodoncia; odontología biológica

Objective: The purpose of this study was to evaluate whether there is a close relationship between the circadian cycle and bone metabolism. Methods: The methodology adopted was the bibliographic search for scientific articles in the Virtual Health Databases (VHLs). Bibliographic Review: scientific evidences were sought for the interference of circadian disruption on bone homeostasis, and to point out possible mechanisms of action of this interference. Sleep abnormalities promote inflammatory, hormonal and metabolic changes causing damage of the bone metabolism, leading to believe that optimizing sleep is a factor of great importance in situations where bone neoformation is desired, such as: growth phase, orthopedic and orthognathic surgeries, installation of dental implants, periodontal treatments and others. Conclusion: It was concluded that there is interference from circadian disruption on bone homeostasis, and the mechanisms by which this interference occurs can be: increased systemic inflammation, increased oxidative stress, hormonal changes, decreased vitamin D and hypoxia.