Multilocus enzyme electrophoresis typing of Candida albicans populations isolated from healthy children according to socioeconomic background

• Autor(a) principal: Boriollo,Marcelo Fabiano Gomes
• Data de Publicação: 2005
• Outros Autores: Rosa,Edvaldo Antônio Ribeiro, Bernardo,Wagner Luis de Carvalho, Spolidorio,Denise Madalena Palomari, Gonçalves,Reginaldo Bruno, Höfling,José Francisco
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista brasileira de epidemiologia (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-790X2005000100007
• topic: Candida albicans; MLEE; Genetic diversity; Healthy children; Socioeconomic category

The aim of this research was to evaluate the genetic diversity within and between C. albicans populations isolated from the oral cavity of healthy Brazilian children classified into five socioeconomic categories (A to E). Multilocus Enzyme Electrophoresis (MLEE) analysis was the method used to assess genetic diversity. High genetic diversity was observed in all populations that showed predominance of some C. albicans subtypes (Electrophoretic Types - ETs). However, no correlation was observed between a specific ET and a specific population of children. Clustering analysis showed one or more highly related ET clusters, suggesting the existence of indirect and direct propagation routes of C. albicans among healthy children. Microevolutionary changes were observed in some C. albicans populations isolated from children with the same or very similar socioeconomic condition. Furthermore, low transition of C. albicans subtypes can be occurring among certain populations of children coming from high and medium/high, or high and medium/low, or medium/high and medium/low socioeconomic categories, which can also be explained by their own socioeconomic and cultural characteristics.