Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses

Detalhes bibliográficos
Autor(a) principal: Nieuwenhuijsen,Mark J.
Data de Publicação: 2010
Outros Autores: Martinez,David, Grellier,James, Bennett,James, Best,Nicky, Iszatt,Nina, Vrijheid,Martine, Toledano,Mireille B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência & Saúde Coletiva (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232010000800015
Resumo: This study aims to review epidemiologic evidence of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies. All epidemiologic studies that evaluated a relationship between an index of DBP exposure and risk of congenital anomalies were analyzed. For all congenital anomalies combined, the meta-analysis gave a statistically significant excess risk for high versus low exposure to water chlorination or TTHM (17%; 95% CI, 3-34) based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95% CI, 21-107), but based on only three studies, and there was little evidence of an exposure-response relationship. It was observed no statistically significant relationships in the other meta-analyses and little evidence for publication bias, except for urinary tract defects and cleft lip and palate. Although some individual studies have suggested an association between chlorination disinfection by-products and congenital anomalies, meta-analyses of all currently available studies demonstrate little evidence of such association.
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spelling Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analysesBirth defectsCongenital anomaliesDisinfection by-productsFetal developmentReproductive healthTrihalomethanesThis study aims to review epidemiologic evidence of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies. All epidemiologic studies that evaluated a relationship between an index of DBP exposure and risk of congenital anomalies were analyzed. For all congenital anomalies combined, the meta-analysis gave a statistically significant excess risk for high versus low exposure to water chlorination or TTHM (17%; 95% CI, 3-34) based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95% CI, 21-107), but based on only three studies, and there was little evidence of an exposure-response relationship. It was observed no statistically significant relationships in the other meta-analyses and little evidence for publication bias, except for urinary tract defects and cleft lip and palate. Although some individual studies have suggested an association between chlorination disinfection by-products and congenital anomalies, meta-analyses of all currently available studies demonstrate little evidence of such association.ABRASCO - Associação Brasileira de Saúde Coletiva2010-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232010000800015Ciência & Saúde Coletiva v.15 suppl.2 2010reponame:Ciência & Saúde Coletiva (Online)instname:Associação Brasileira de Saúde Coletiva (ABRASCO)instacron:ABRASCO10.1590/S1413-81232010000800015info:eu-repo/semantics/openAccessNieuwenhuijsen,Mark J.Martinez,DavidGrellier,JamesBennett,JamesBest,NickyIszatt,NinaVrijheid,MartineToledano,Mireille B.eng2010-11-22T00:00:00Zoai:scielo:S1413-81232010000800015Revistahttp://www.cienciaesaudecoletiva.com.brhttps://old.scielo.br/oai/scielo-oai.php||cienciasaudecoletiva@fiocruz.br1678-45611413-8123opendoar:2010-11-22T00:00Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO)false
dc.title.none.fl_str_mv Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses
title Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses
spellingShingle Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses
Nieuwenhuijsen,Mark J.
Birth defects
Congenital anomalies
Disinfection by-products
Fetal development
Reproductive health
Trihalomethanes
title_short Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses
title_full Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses
title_fullStr Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses
title_full_unstemmed Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses
title_sort Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses
author Nieuwenhuijsen,Mark J.
author_facet Nieuwenhuijsen,Mark J.
Martinez,David
Grellier,James
Bennett,James
Best,Nicky
Iszatt,Nina
Vrijheid,Martine
Toledano,Mireille B.
author_role author
author2 Martinez,David
Grellier,James
Bennett,James
Best,Nicky
Iszatt,Nina
Vrijheid,Martine
Toledano,Mireille B.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Nieuwenhuijsen,Mark J.
Martinez,David
Grellier,James
Bennett,James
Best,Nicky
Iszatt,Nina
Vrijheid,Martine
Toledano,Mireille B.
dc.subject.por.fl_str_mv Birth defects
Congenital anomalies
Disinfection by-products
Fetal development
Reproductive health
Trihalomethanes
topic Birth defects
Congenital anomalies
Disinfection by-products
Fetal development
Reproductive health
Trihalomethanes
description This study aims to review epidemiologic evidence of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies. All epidemiologic studies that evaluated a relationship between an index of DBP exposure and risk of congenital anomalies were analyzed. For all congenital anomalies combined, the meta-analysis gave a statistically significant excess risk for high versus low exposure to water chlorination or TTHM (17%; 95% CI, 3-34) based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95% CI, 21-107), but based on only three studies, and there was little evidence of an exposure-response relationship. It was observed no statistically significant relationships in the other meta-analyses and little evidence for publication bias, except for urinary tract defects and cleft lip and palate. Although some individual studies have suggested an association between chlorination disinfection by-products and congenital anomalies, meta-analyses of all currently available studies demonstrate little evidence of such association.
publishDate 2010
dc.date.none.fl_str_mv 2010-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232010000800015
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232010000800015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-81232010000800015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv ABRASCO - Associação Brasileira de Saúde Coletiva
publisher.none.fl_str_mv ABRASCO - Associação Brasileira de Saúde Coletiva
dc.source.none.fl_str_mv Ciência & Saúde Coletiva v.15 suppl.2 2010
reponame:Ciência & Saúde Coletiva (Online)
instname:Associação Brasileira de Saúde Coletiva (ABRASCO)
instacron:ABRASCO
instname_str Associação Brasileira de Saúde Coletiva (ABRASCO)
instacron_str ABRASCO
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reponame_str Ciência & Saúde Coletiva (Online)
collection Ciência & Saúde Coletiva (Online)
repository.name.fl_str_mv Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO)
repository.mail.fl_str_mv ||cienciasaudecoletiva@fiocruz.br
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