Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Ciência & Saúde Coletiva (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232010000800015 |
Resumo: | This study aims to review epidemiologic evidence of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies. All epidemiologic studies that evaluated a relationship between an index of DBP exposure and risk of congenital anomalies were analyzed. For all congenital anomalies combined, the meta-analysis gave a statistically significant excess risk for high versus low exposure to water chlorination or TTHM (17%; 95% CI, 3-34) based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95% CI, 21-107), but based on only three studies, and there was little evidence of an exposure-response relationship. It was observed no statistically significant relationships in the other meta-analyses and little evidence for publication bias, except for urinary tract defects and cleft lip and palate. Although some individual studies have suggested an association between chlorination disinfection by-products and congenital anomalies, meta-analyses of all currently available studies demonstrate little evidence of such association. |
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Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analysesBirth defectsCongenital anomaliesDisinfection by-productsFetal developmentReproductive healthTrihalomethanesThis study aims to review epidemiologic evidence of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies. All epidemiologic studies that evaluated a relationship between an index of DBP exposure and risk of congenital anomalies were analyzed. For all congenital anomalies combined, the meta-analysis gave a statistically significant excess risk for high versus low exposure to water chlorination or TTHM (17%; 95% CI, 3-34) based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95% CI, 21-107), but based on only three studies, and there was little evidence of an exposure-response relationship. It was observed no statistically significant relationships in the other meta-analyses and little evidence for publication bias, except for urinary tract defects and cleft lip and palate. Although some individual studies have suggested an association between chlorination disinfection by-products and congenital anomalies, meta-analyses of all currently available studies demonstrate little evidence of such association.ABRASCO - Associação Brasileira de Saúde Coletiva2010-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232010000800015Ciência & Saúde Coletiva v.15 suppl.2 2010reponame:Ciência & Saúde Coletiva (Online)instname:Associação Brasileira de Saúde Coletiva (ABRASCO)instacron:ABRASCO10.1590/S1413-81232010000800015info:eu-repo/semantics/openAccessNieuwenhuijsen,Mark J.Martinez,DavidGrellier,JamesBennett,JamesBest,NickyIszatt,NinaVrijheid,MartineToledano,Mireille B.eng2010-11-22T00:00:00Zoai:scielo:S1413-81232010000800015Revistahttp://www.cienciaesaudecoletiva.com.brhttps://old.scielo.br/oai/scielo-oai.php||cienciasaudecoletiva@fiocruz.br1678-45611413-8123opendoar:2010-11-22T00:00Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO)false |
dc.title.none.fl_str_mv |
Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses |
title |
Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses |
spellingShingle |
Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses Nieuwenhuijsen,Mark J. Birth defects Congenital anomalies Disinfection by-products Fetal development Reproductive health Trihalomethanes |
title_short |
Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses |
title_full |
Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses |
title_fullStr |
Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses |
title_full_unstemmed |
Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses |
title_sort |
Chlorination disinfection by-products in drinking water and congenital anomalies: review and meta-analyses |
author |
Nieuwenhuijsen,Mark J. |
author_facet |
Nieuwenhuijsen,Mark J. Martinez,David Grellier,James Bennett,James Best,Nicky Iszatt,Nina Vrijheid,Martine Toledano,Mireille B. |
author_role |
author |
author2 |
Martinez,David Grellier,James Bennett,James Best,Nicky Iszatt,Nina Vrijheid,Martine Toledano,Mireille B. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Nieuwenhuijsen,Mark J. Martinez,David Grellier,James Bennett,James Best,Nicky Iszatt,Nina Vrijheid,Martine Toledano,Mireille B. |
dc.subject.por.fl_str_mv |
Birth defects Congenital anomalies Disinfection by-products Fetal development Reproductive health Trihalomethanes |
topic |
Birth defects Congenital anomalies Disinfection by-products Fetal development Reproductive health Trihalomethanes |
description |
This study aims to review epidemiologic evidence of the association between exposure to chlorination disinfection by-products (DBPs) and congenital anomalies. All epidemiologic studies that evaluated a relationship between an index of DBP exposure and risk of congenital anomalies were analyzed. For all congenital anomalies combined, the meta-analysis gave a statistically significant excess risk for high versus low exposure to water chlorination or TTHM (17%; 95% CI, 3-34) based on a small number of studies. The meta-analysis also suggested a statistically significant excess risk for ventricular septal defects (58%; 95% CI, 21-107), but based on only three studies, and there was little evidence of an exposure-response relationship. It was observed no statistically significant relationships in the other meta-analyses and little evidence for publication bias, except for urinary tract defects and cleft lip and palate. Although some individual studies have suggested an association between chlorination disinfection by-products and congenital anomalies, meta-analyses of all currently available studies demonstrate little evidence of such association. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232010000800015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-81232010000800015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-81232010000800015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
ABRASCO - Associação Brasileira de Saúde Coletiva |
publisher.none.fl_str_mv |
ABRASCO - Associação Brasileira de Saúde Coletiva |
dc.source.none.fl_str_mv |
Ciência & Saúde Coletiva v.15 suppl.2 2010 reponame:Ciência & Saúde Coletiva (Online) instname:Associação Brasileira de Saúde Coletiva (ABRASCO) instacron:ABRASCO |
instname_str |
Associação Brasileira de Saúde Coletiva (ABRASCO) |
instacron_str |
ABRASCO |
institution |
ABRASCO |
reponame_str |
Ciência & Saúde Coletiva (Online) |
collection |
Ciência & Saúde Coletiva (Online) |
repository.name.fl_str_mv |
Ciência & Saúde Coletiva (Online) - Associação Brasileira de Saúde Coletiva (ABRASCO) |
repository.mail.fl_str_mv |
||cienciasaudecoletiva@fiocruz.br |
_version_ |
1754213029673697280 |