Vitamin B12, bone mineral density and fracture risk in adults: A systematic review
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000900801 |
Resumo: | Summary Objective: To consolidate information available on the effect of vitamin B12 on bone mineral density and fracture risk, with emphasis on clinical trials, observational and longitudinal data conducted in humans. Method: A systematic review of the literature of the past decade on the role of vitamin B12 in bone mineral density and fracture risk in subjects of all ages and both sexes was performed by means of a PubMed, Science Direct, Medline and SciELO database search. Articles included in this review were identified using the search terms: B12 Vitamin and Bone Mineral Density and Vitamin B12 and Risk of Fractures. Evidence quality of the included articles was evaluated by GRADE system. Results: A total of 25 original studies were identified. After reviewing the titles and abstracts of articles, only 17 articles met the inclusion criteria. The present review provides evidence that the role of vitamin B12 on bone mineral density or fracture risk should be further elucidated. Controversies are explained by heterogeneity of methodologies used for the diagnosis of vitamin B12 and also by differences among populations investigated on the studies. Conclusion: A real effect of vitamin B12 deficiency in bone health and the mechanisms associated with bone metabolism is not well established yet. It is extremely important to carry out more clarifying studies about this theme, especially with vulnerable groups such as postmenopausal and elderly women, as is well-known that they are greatly affected by deficiency of this vitamin. |
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Vitamin B12, bone mineral density and fracture risk in adults: A systematic reviewbone health vitaminB12 vitamin supplementationfracture riskSummary Objective: To consolidate information available on the effect of vitamin B12 on bone mineral density and fracture risk, with emphasis on clinical trials, observational and longitudinal data conducted in humans. Method: A systematic review of the literature of the past decade on the role of vitamin B12 in bone mineral density and fracture risk in subjects of all ages and both sexes was performed by means of a PubMed, Science Direct, Medline and SciELO database search. Articles included in this review were identified using the search terms: B12 Vitamin and Bone Mineral Density and Vitamin B12 and Risk of Fractures. Evidence quality of the included articles was evaluated by GRADE system. Results: A total of 25 original studies were identified. After reviewing the titles and abstracts of articles, only 17 articles met the inclusion criteria. The present review provides evidence that the role of vitamin B12 on bone mineral density or fracture risk should be further elucidated. Controversies are explained by heterogeneity of methodologies used for the diagnosis of vitamin B12 and also by differences among populations investigated on the studies. Conclusion: A real effect of vitamin B12 deficiency in bone health and the mechanisms associated with bone metabolism is not well established yet. It is extremely important to carry out more clarifying studies about this theme, especially with vulnerable groups such as postmenopausal and elderly women, as is well-known that they are greatly affected by deficiency of this vitamin.Associação Médica Brasileira2017-19-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000900801Revista da Associação Médica Brasileira v.63 n.9 2017reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.63.09.801info:eu-repo/semantics/openAccessMacêdo,Luciana Leal Gomes deCarvalho,Cecilia Maria Resende Gonçalves deCavalcanti,Janaína CostaFreitas,Betania de Jesus e Silva de Almendraeng2018-02-22T00:00:00Zoai:scielo:S0104-42302017000900801Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2018-02-22T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Vitamin B12, bone mineral density and fracture risk in adults: A systematic review |
title |
Vitamin B12, bone mineral density and fracture risk in adults: A systematic review |
spellingShingle |
Vitamin B12, bone mineral density and fracture risk in adults: A systematic review Macêdo,Luciana Leal Gomes de bone health vitamin B12 vitamin supplementation fracture risk |
title_short |
Vitamin B12, bone mineral density and fracture risk in adults: A systematic review |
title_full |
Vitamin B12, bone mineral density and fracture risk in adults: A systematic review |
title_fullStr |
Vitamin B12, bone mineral density and fracture risk in adults: A systematic review |
title_full_unstemmed |
Vitamin B12, bone mineral density and fracture risk in adults: A systematic review |
title_sort |
Vitamin B12, bone mineral density and fracture risk in adults: A systematic review |
author |
Macêdo,Luciana Leal Gomes de |
author_facet |
Macêdo,Luciana Leal Gomes de Carvalho,Cecilia Maria Resende Gonçalves de Cavalcanti,Janaína Costa Freitas,Betania de Jesus e Silva de Almendra |
author_role |
author |
author2 |
Carvalho,Cecilia Maria Resende Gonçalves de Cavalcanti,Janaína Costa Freitas,Betania de Jesus e Silva de Almendra |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Macêdo,Luciana Leal Gomes de Carvalho,Cecilia Maria Resende Gonçalves de Cavalcanti,Janaína Costa Freitas,Betania de Jesus e Silva de Almendra |
dc.subject.por.fl_str_mv |
bone health vitamin B12 vitamin supplementation fracture risk |
topic |
bone health vitamin B12 vitamin supplementation fracture risk |
description |
Summary Objective: To consolidate information available on the effect of vitamin B12 on bone mineral density and fracture risk, with emphasis on clinical trials, observational and longitudinal data conducted in humans. Method: A systematic review of the literature of the past decade on the role of vitamin B12 in bone mineral density and fracture risk in subjects of all ages and both sexes was performed by means of a PubMed, Science Direct, Medline and SciELO database search. Articles included in this review were identified using the search terms: B12 Vitamin and Bone Mineral Density and Vitamin B12 and Risk of Fractures. Evidence quality of the included articles was evaluated by GRADE system. Results: A total of 25 original studies were identified. After reviewing the titles and abstracts of articles, only 17 articles met the inclusion criteria. The present review provides evidence that the role of vitamin B12 on bone mineral density or fracture risk should be further elucidated. Controversies are explained by heterogeneity of methodologies used for the diagnosis of vitamin B12 and also by differences among populations investigated on the studies. Conclusion: A real effect of vitamin B12 deficiency in bone health and the mechanisms associated with bone metabolism is not well established yet. It is extremely important to carry out more clarifying studies about this theme, especially with vulnerable groups such as postmenopausal and elderly women, as is well-known that they are greatly affected by deficiency of this vitamin. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-19-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000900801 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302017000900801 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.63.09.801 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.63 n.9 2017 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212832962936832 |