Prognostic nutritional index and the risk of acute kidney injury in patients with acute coronary syndrome
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302021000901124 |
Resumo: | SUMMARY OBJECTIVE Recent studies have linked malnutrition with undesirable outcomes in cardiovascular diseases. However, the underlying mechanism is unknown. Contrast-induced acute kidney injury (CI-AKI) increased cardiovascular mortality after percutaneous coronary intervention (PCI). This study hypothesizes that prognostic nutritional index (PNI) plays a role in the development of CI-AKI in patients with acute coronary syndrome undergoing emergency PCI. METHODS This study enrolled 551 patients. PNI was determined as 10× serum albumin (g/dL)+0.005×total lymphocyte count (mm3). CI-AKI was characterized as the increase in serum creatinine ≥0.3 mg/dL level within 48 h after PCI. Patients were classified as either CI-AKI (+) or CI-AKI (−). RESULTS CI-AKI has occurred in 72 of 551 patients (13.1%). PNI was significantly lower in the CI-AKI (+) group than in the CI-AKI (-) group (44.4±6.6 versus 47.2±5.8, p<0.001, respectively). Multivariate logistic regression analysis showed that PNI [odds ratio, OR: 1.631, 95% confidence interval (CI): 1.168–2.308, p=0.02] and estimated glomerular filtration rate (OR: 3.26, 95%CI 1.733–6.143, p<0.001) were independent risk factors for CI-AKI. CONCLUSIONS PNI is an independent risk factor for CI-AKI. The development of CI-AKI may be the mechanism responsible for the relationship between poor nutritional status and adverse cardiac events. |
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Prognostic nutritional index and the risk of acute kidney injury in patients with acute coronary syndromePrognostic nutritional indexAcute kidney injuryAcute coronary syndromePercutaneous coronary interventionSUMMARY OBJECTIVE Recent studies have linked malnutrition with undesirable outcomes in cardiovascular diseases. However, the underlying mechanism is unknown. Contrast-induced acute kidney injury (CI-AKI) increased cardiovascular mortality after percutaneous coronary intervention (PCI). This study hypothesizes that prognostic nutritional index (PNI) plays a role in the development of CI-AKI in patients with acute coronary syndrome undergoing emergency PCI. METHODS This study enrolled 551 patients. PNI was determined as 10× serum albumin (g/dL)+0.005×total lymphocyte count (mm3). CI-AKI was characterized as the increase in serum creatinine ≥0.3 mg/dL level within 48 h after PCI. Patients were classified as either CI-AKI (+) or CI-AKI (−). RESULTS CI-AKI has occurred in 72 of 551 patients (13.1%). PNI was significantly lower in the CI-AKI (+) group than in the CI-AKI (-) group (44.4±6.6 versus 47.2±5.8, p<0.001, respectively). Multivariate logistic regression analysis showed that PNI [odds ratio, OR: 1.631, 95% confidence interval (CI): 1.168–2.308, p=0.02] and estimated glomerular filtration rate (OR: 3.26, 95%CI 1.733–6.143, p<0.001) were independent risk factors for CI-AKI. CONCLUSIONS PNI is an independent risk factor for CI-AKI. The development of CI-AKI may be the mechanism responsible for the relationship between poor nutritional status and adverse cardiac events.Associação Médica Brasileira2021-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302021000901124Revista da Associação Médica Brasileira v.67 n.8 2021reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.20210460info:eu-repo/semantics/openAccessSertdemir,Ahmet Lütfüİcli,AbdullahAribas,AlpayTatar,SefaAkilli,Nazire BelginAlsancak,YakupAkilli,Hakaneng2021-10-27T00:00:00Zoai:scielo:S0104-42302021000901124Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2021-10-27T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Prognostic nutritional index and the risk of acute kidney injury in patients with acute coronary syndrome |
title |
Prognostic nutritional index and the risk of acute kidney injury in patients with acute coronary syndrome |
spellingShingle |
Prognostic nutritional index and the risk of acute kidney injury in patients with acute coronary syndrome Sertdemir,Ahmet Lütfü Prognostic nutritional index Acute kidney injury Acute coronary syndrome Percutaneous coronary intervention |
title_short |
Prognostic nutritional index and the risk of acute kidney injury in patients with acute coronary syndrome |
title_full |
Prognostic nutritional index and the risk of acute kidney injury in patients with acute coronary syndrome |
title_fullStr |
Prognostic nutritional index and the risk of acute kidney injury in patients with acute coronary syndrome |
title_full_unstemmed |
Prognostic nutritional index and the risk of acute kidney injury in patients with acute coronary syndrome |
title_sort |
Prognostic nutritional index and the risk of acute kidney injury in patients with acute coronary syndrome |
author |
Sertdemir,Ahmet Lütfü |
author_facet |
Sertdemir,Ahmet Lütfü İcli,Abdullah Aribas,Alpay Tatar,Sefa Akilli,Nazire Belgin Alsancak,Yakup Akilli,Hakan |
author_role |
author |
author2 |
İcli,Abdullah Aribas,Alpay Tatar,Sefa Akilli,Nazire Belgin Alsancak,Yakup Akilli,Hakan |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Sertdemir,Ahmet Lütfü İcli,Abdullah Aribas,Alpay Tatar,Sefa Akilli,Nazire Belgin Alsancak,Yakup Akilli,Hakan |
dc.subject.por.fl_str_mv |
Prognostic nutritional index Acute kidney injury Acute coronary syndrome Percutaneous coronary intervention |
topic |
Prognostic nutritional index Acute kidney injury Acute coronary syndrome Percutaneous coronary intervention |
description |
SUMMARY OBJECTIVE Recent studies have linked malnutrition with undesirable outcomes in cardiovascular diseases. However, the underlying mechanism is unknown. Contrast-induced acute kidney injury (CI-AKI) increased cardiovascular mortality after percutaneous coronary intervention (PCI). This study hypothesizes that prognostic nutritional index (PNI) plays a role in the development of CI-AKI in patients with acute coronary syndrome undergoing emergency PCI. METHODS This study enrolled 551 patients. PNI was determined as 10× serum albumin (g/dL)+0.005×total lymphocyte count (mm3). CI-AKI was characterized as the increase in serum creatinine ≥0.3 mg/dL level within 48 h after PCI. Patients were classified as either CI-AKI (+) or CI-AKI (−). RESULTS CI-AKI has occurred in 72 of 551 patients (13.1%). PNI was significantly lower in the CI-AKI (+) group than in the CI-AKI (-) group (44.4±6.6 versus 47.2±5.8, p<0.001, respectively). Multivariate logistic regression analysis showed that PNI [odds ratio, OR: 1.631, 95% confidence interval (CI): 1.168–2.308, p=0.02] and estimated glomerular filtration rate (OR: 3.26, 95%CI 1.733–6.143, p<0.001) were independent risk factors for CI-AKI. CONCLUSIONS PNI is an independent risk factor for CI-AKI. The development of CI-AKI may be the mechanism responsible for the relationship between poor nutritional status and adverse cardiac events. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302021000901124 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302021000901124 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.20210460 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.67 n.8 2021 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212836514463744 |