Outcome of children and adolescents with lymphoblastic lymphoma

Detalhes bibliográficos
Autor(a) principal: Oliveira,Maria Christina Lopes Araújo
Data de Publicação: 2016
Outros Autores: Sampaio,Keyla Christy, Oliveira,Aline Carneiro, Santos,Aieska Dantas, Castro,Lúcia Porto, Viana,Marcos Borato
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000100059
Resumo: SUMMARY Introduction: lymphoblastic lymphoma (LBL) is the second most common subtype of non-Hodgkin lymphoma in children. The aim of this study was to characterize the clinical course of children and adolescents with LBL treated at a tertiary center. Methods: this is a retrospective cohort study of 27 patients aged 16 years or less with LBL admitted between January 1981 and December 2013. Patients received intensive chemotherapy regimen derived from acute lymphoblastic leukemia (ALL) therapy. Diagnosis was based on biopsy of tumor and/or cytological examination of pleural effusions. The overall survival was analyzed using the Kaplan-Meier method. Results: the median age at diagnosis was 11.6 years (interquartile range, 4.6-13.8). LBL had T cell origin in 16 patients (59%). The most common primary manifestation in T-cell LBL was mediastinum involvement in 9 patients (56%). Intra-abdominal tumor was the major site of involvement in patients with pB-LBL. Most patients had advanced disease (18 patients - 67%) at diagnosis. Twenty-four patients (89%) achieved complete clinical remission. After a median follow-up of 43 months (interquartile range, 6.4-95), 22 patients (81%) were alive in first complete remission. Five children (18.5%) died, three of them soon after admission and two after relapsing. The probability of survival at five years for 20 patients with de novo LBL was 78% (SD 9.4). Conclusion: our findings confirm the favorable prognosis of children with LBL with an intensive chemotherapy regimen derived from ALL therapy.
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spelling Outcome of children and adolescents with lymphoblastic lymphomaprecursor cell lymphoblastic leukemia-lymphomalymphomanon-HodgkinpediatricssurvivalSUMMARY Introduction: lymphoblastic lymphoma (LBL) is the second most common subtype of non-Hodgkin lymphoma in children. The aim of this study was to characterize the clinical course of children and adolescents with LBL treated at a tertiary center. Methods: this is a retrospective cohort study of 27 patients aged 16 years or less with LBL admitted between January 1981 and December 2013. Patients received intensive chemotherapy regimen derived from acute lymphoblastic leukemia (ALL) therapy. Diagnosis was based on biopsy of tumor and/or cytological examination of pleural effusions. The overall survival was analyzed using the Kaplan-Meier method. Results: the median age at diagnosis was 11.6 years (interquartile range, 4.6-13.8). LBL had T cell origin in 16 patients (59%). The most common primary manifestation in T-cell LBL was mediastinum involvement in 9 patients (56%). Intra-abdominal tumor was the major site of involvement in patients with pB-LBL. Most patients had advanced disease (18 patients - 67%) at diagnosis. Twenty-four patients (89%) achieved complete clinical remission. After a median follow-up of 43 months (interquartile range, 6.4-95), 22 patients (81%) were alive in first complete remission. Five children (18.5%) died, three of them soon after admission and two after relapsing. The probability of survival at five years for 20 patients with de novo LBL was 78% (SD 9.4). Conclusion: our findings confirm the favorable prognosis of children with LBL with an intensive chemotherapy regimen derived from ALL therapy.Associação Médica Brasileira2016-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302016000100059Revista da Associação Médica Brasileira v.62 n.1 2016reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.62.01.59info:eu-repo/semantics/openAccessOliveira,Maria Christina Lopes AraújoSampaio,Keyla ChristyOliveira,Aline CarneiroSantos,Aieska DantasCastro,Lúcia PortoViana,Marcos Boratoeng2016-03-18T00:00:00Zoai:scielo:S0104-42302016000100059Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2016-03-18T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Outcome of children and adolescents with lymphoblastic lymphoma
title Outcome of children and adolescents with lymphoblastic lymphoma
spellingShingle Outcome of children and adolescents with lymphoblastic lymphoma
Oliveira,Maria Christina Lopes Araújo
precursor cell lymphoblastic leukemia-lymphoma
lymphoma
non-Hodgkin
pediatrics
survival
title_short Outcome of children and adolescents with lymphoblastic lymphoma
title_full Outcome of children and adolescents with lymphoblastic lymphoma
title_fullStr Outcome of children and adolescents with lymphoblastic lymphoma
title_full_unstemmed Outcome of children and adolescents with lymphoblastic lymphoma
title_sort Outcome of children and adolescents with lymphoblastic lymphoma
author Oliveira,Maria Christina Lopes Araújo
author_facet Oliveira,Maria Christina Lopes Araújo
Sampaio,Keyla Christy
Oliveira,Aline Carneiro
Santos,Aieska Dantas
Castro,Lúcia Porto
Viana,Marcos Borato
author_role author
author2 Sampaio,Keyla Christy
Oliveira,Aline Carneiro
Santos,Aieska Dantas
Castro,Lúcia Porto
Viana,Marcos Borato
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Oliveira,Maria Christina Lopes Araújo
Sampaio,Keyla Christy
Oliveira,Aline Carneiro
Santos,Aieska Dantas
Castro,Lúcia Porto
Viana,Marcos Borato
dc.subject.por.fl_str_mv precursor cell lymphoblastic leukemia-lymphoma
lymphoma
non-Hodgkin
pediatrics
survival
topic precursor cell lymphoblastic leukemia-lymphoma
lymphoma
non-Hodgkin
pediatrics
survival
description SUMMARY Introduction: lymphoblastic lymphoma (LBL) is the second most common subtype of non-Hodgkin lymphoma in children. The aim of this study was to characterize the clinical course of children and adolescents with LBL treated at a tertiary center. Methods: this is a retrospective cohort study of 27 patients aged 16 years or less with LBL admitted between January 1981 and December 2013. Patients received intensive chemotherapy regimen derived from acute lymphoblastic leukemia (ALL) therapy. Diagnosis was based on biopsy of tumor and/or cytological examination of pleural effusions. The overall survival was analyzed using the Kaplan-Meier method. Results: the median age at diagnosis was 11.6 years (interquartile range, 4.6-13.8). LBL had T cell origin in 16 patients (59%). The most common primary manifestation in T-cell LBL was mediastinum involvement in 9 patients (56%). Intra-abdominal tumor was the major site of involvement in patients with pB-LBL. Most patients had advanced disease (18 patients - 67%) at diagnosis. Twenty-four patients (89%) achieved complete clinical remission. After a median follow-up of 43 months (interquartile range, 6.4-95), 22 patients (81%) were alive in first complete remission. Five children (18.5%) died, three of them soon after admission and two after relapsing. The probability of survival at five years for 20 patients with de novo LBL was 78% (SD 9.4). Conclusion: our findings confirm the favorable prognosis of children with LBL with an intensive chemotherapy regimen derived from ALL therapy.
publishDate 2016
dc.date.none.fl_str_mv 2016-02-01
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dc.language.iso.fl_str_mv eng
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dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.62 n.1 2016
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