Infliximab-induced remission improves physical activity in patients with active Crohn's disease

Detalhes bibliográficos
Autor(a) principal: Lucca,Fernando de Azevedo
Data de Publicação: 2020
Outros Autores: Malaguti,Carla, Chebli,Liliana Andrade, Reboredo,Maycon Moura, Pinheiro,Bruno Valle, Ribeiro,Tarsila Campanha da Rocha, Azevedo,Felipe Meirelles de, Corrêa,José Otávio do Amaral, Gaburri,Pedro Duarte, Chebli,Julio Maria Fonseca
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001101566
Resumo: SUMMARY AIM: To compare the level of physical activity (PA), exercise capacity, and body composition before and after infliximab-induced clinical remission in patients with Crohn's disease (CD). METHODS: This prospective longitudinal study evaluated 44 adult outpatients with active CD before infliximab administration and 24 weeks after infliximab therapy. The patients were evaluated for PA in daily life, exercise capacity, muscle strength, and body composition. RESULTS: 38 (86.4%) patients achieved infliximab-induced remission at 24 weeks and presented an increment in the number of steps taken of 1092 (7440±2980 vs. 6348±3177, respectively; p=0.006). The inactive time was reduced when compared to the baseline value (454.2±106.3 vs. 427.9±97.8, respectively; p=0.033). There was no difference in the distance walked before and after infliximab therapy, while there was an increase in the fat mass index in responders to infliximab compared to the baseline (19.1±7.6 vs. 14.9±5.8; p=0.001). CONCLUSIONS: Infliximab-induced remission was shown to be effective for increasing physical activity by improving the number of steps and reducing inactive time. The maintenance of clinical remission associated with incentives to regular PA may contribute to making these patients reach an ideal level of PA.
id AMB-1_5c144a923b0dcf50ea76aef1f2b81fb1
oai_identifier_str oai:scielo:S0104-42302020001101566
network_acronym_str AMB-1
network_name_str Revista da Associação Médica Brasileira (Online)
repository_id_str
spelling Infliximab-induced remission improves physical activity in patients with active Crohn's diseaseCrohn diseaseInflammatory Bowel DiseasesInfliximab. Motor activitySUMMARY AIM: To compare the level of physical activity (PA), exercise capacity, and body composition before and after infliximab-induced clinical remission in patients with Crohn's disease (CD). METHODS: This prospective longitudinal study evaluated 44 adult outpatients with active CD before infliximab administration and 24 weeks after infliximab therapy. The patients were evaluated for PA in daily life, exercise capacity, muscle strength, and body composition. RESULTS: 38 (86.4%) patients achieved infliximab-induced remission at 24 weeks and presented an increment in the number of steps taken of 1092 (7440±2980 vs. 6348±3177, respectively; p=0.006). The inactive time was reduced when compared to the baseline value (454.2±106.3 vs. 427.9±97.8, respectively; p=0.033). There was no difference in the distance walked before and after infliximab therapy, while there was an increase in the fat mass index in responders to infliximab compared to the baseline (19.1±7.6 vs. 14.9±5.8; p=0.001). CONCLUSIONS: Infliximab-induced remission was shown to be effective for increasing physical activity by improving the number of steps and reducing inactive time. The maintenance of clinical remission associated with incentives to regular PA may contribute to making these patients reach an ideal level of PA.Associação Médica Brasileira2020-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001101566Revista da Associação Médica Brasileira v.66 n.11 2020reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.66.11.1566info:eu-repo/semantics/openAccessLucca,Fernando de AzevedoMalaguti,CarlaChebli,Liliana AndradeReboredo,Maycon MouraPinheiro,Bruno ValleRibeiro,Tarsila Campanha da RochaAzevedo,Felipe Meirelles deCorrêa,José Otávio do AmaralGaburri,Pedro DuarteChebli,Julio Maria Fonsecaeng2020-11-30T00:00:00Zoai:scielo:S0104-42302020001101566Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2020-11-30T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Infliximab-induced remission improves physical activity in patients with active Crohn's disease
title Infliximab-induced remission improves physical activity in patients with active Crohn's disease
spellingShingle Infliximab-induced remission improves physical activity in patients with active Crohn's disease
Lucca,Fernando de Azevedo
Crohn disease
Inflammatory Bowel Diseases
Infliximab. Motor activity
title_short Infliximab-induced remission improves physical activity in patients with active Crohn's disease
title_full Infliximab-induced remission improves physical activity in patients with active Crohn's disease
title_fullStr Infliximab-induced remission improves physical activity in patients with active Crohn's disease
title_full_unstemmed Infliximab-induced remission improves physical activity in patients with active Crohn's disease
title_sort Infliximab-induced remission improves physical activity in patients with active Crohn's disease
author Lucca,Fernando de Azevedo
author_facet Lucca,Fernando de Azevedo
Malaguti,Carla
Chebli,Liliana Andrade
Reboredo,Maycon Moura
Pinheiro,Bruno Valle
Ribeiro,Tarsila Campanha da Rocha
Azevedo,Felipe Meirelles de
Corrêa,José Otávio do Amaral
Gaburri,Pedro Duarte
Chebli,Julio Maria Fonseca
author_role author
author2 Malaguti,Carla
Chebli,Liliana Andrade
Reboredo,Maycon Moura
Pinheiro,Bruno Valle
Ribeiro,Tarsila Campanha da Rocha
Azevedo,Felipe Meirelles de
Corrêa,José Otávio do Amaral
Gaburri,Pedro Duarte
Chebli,Julio Maria Fonseca
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lucca,Fernando de Azevedo
Malaguti,Carla
Chebli,Liliana Andrade
Reboredo,Maycon Moura
Pinheiro,Bruno Valle
Ribeiro,Tarsila Campanha da Rocha
Azevedo,Felipe Meirelles de
Corrêa,José Otávio do Amaral
Gaburri,Pedro Duarte
Chebli,Julio Maria Fonseca
dc.subject.por.fl_str_mv Crohn disease
Inflammatory Bowel Diseases
Infliximab. Motor activity
topic Crohn disease
Inflammatory Bowel Diseases
Infliximab. Motor activity
description SUMMARY AIM: To compare the level of physical activity (PA), exercise capacity, and body composition before and after infliximab-induced clinical remission in patients with Crohn's disease (CD). METHODS: This prospective longitudinal study evaluated 44 adult outpatients with active CD before infliximab administration and 24 weeks after infliximab therapy. The patients were evaluated for PA in daily life, exercise capacity, muscle strength, and body composition. RESULTS: 38 (86.4%) patients achieved infliximab-induced remission at 24 weeks and presented an increment in the number of steps taken of 1092 (7440±2980 vs. 6348±3177, respectively; p=0.006). The inactive time was reduced when compared to the baseline value (454.2±106.3 vs. 427.9±97.8, respectively; p=0.033). There was no difference in the distance walked before and after infliximab therapy, while there was an increase in the fat mass index in responders to infliximab compared to the baseline (19.1±7.6 vs. 14.9±5.8; p=0.001). CONCLUSIONS: Infliximab-induced remission was shown to be effective for increasing physical activity by improving the number of steps and reducing inactive time. The maintenance of clinical remission associated with incentives to regular PA may contribute to making these patients reach an ideal level of PA.
publishDate 2020
dc.date.none.fl_str_mv 2020-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001101566
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001101566
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1806-9282.66.11.1566
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.66 n.11 2020
reponame:Revista da Associação Médica Brasileira (Online)
instname:Associação Médica Brasileira (AMB)
instacron:AMB
instname_str Associação Médica Brasileira (AMB)
instacron_str AMB
institution AMB
reponame_str Revista da Associação Médica Brasileira (Online)
collection Revista da Associação Médica Brasileira (Online)
repository.name.fl_str_mv Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)
repository.mail.fl_str_mv ||ramb@amb.org.br
_version_ 1754212835573891072