The role of Survivin as a biomarker and potential prognostic factor for breast cancer
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000600893 |
Resumo: | SUMMARY Breast cancer (BC) is one of the primary health problems worldwide. As the most common cancer in women in the world and in Brasil, behind only non-melanoma skin cancer, this neoplasm corresponds to approximately 28% of new cases per year in the country. BC also affects men, although the incidence corresponds to only 1% of total cases. Currently, most of the chemotherapeutic agents used in BC treatment are extremely toxic and cause long-term side effects. There is also a need to obtain earlier diagnoses, more accurate prognoses and make new therapies available that are more selective and effective in order to improve the current scenario. Therefore, this work sought to evaluate the importance of the biomarker survivin (Sur) in relation to BC, through the detailing of the role of Sur as a biomarker, the correlation between this protein and the prognosis of BC patients, and a summary of therapeutic strategies that target Sur for the development of new anticancer therapies. |
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The role of Survivin as a biomarker and potential prognostic factor for breast cancerBreast NeoplasmsPrognosisNeoplasm MetastasisInhibitor of Apoptosis ProteinsSUMMARY Breast cancer (BC) is one of the primary health problems worldwide. As the most common cancer in women in the world and in Brasil, behind only non-melanoma skin cancer, this neoplasm corresponds to approximately 28% of new cases per year in the country. BC also affects men, although the incidence corresponds to only 1% of total cases. Currently, most of the chemotherapeutic agents used in BC treatment are extremely toxic and cause long-term side effects. There is also a need to obtain earlier diagnoses, more accurate prognoses and make new therapies available that are more selective and effective in order to improve the current scenario. Therefore, this work sought to evaluate the importance of the biomarker survivin (Sur) in relation to BC, through the detailing of the role of Sur as a biomarker, the correlation between this protein and the prognosis of BC patients, and a summary of therapeutic strategies that target Sur for the development of new anticancer therapies.Associação Médica Brasileira2019-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000600893Revista da Associação Médica Brasileira v.65 n.6 2019reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.65.6.893info:eu-repo/semantics/openAccessVeiga,Glaucia Luciano daSilva,Raissa Daniel Machado daPereira,Edimar CristianoAzzalis,Ligia AjaimeAlves,Beatriz da Costa AguiarGehrke,Flavia de SousaGascón,Thaís MouraFonseca,Fernando Luiz Affonsoeng2019-07-22T00:00:00Zoai:scielo:S0104-42302019000600893Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2019-07-22T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
The role of Survivin as a biomarker and potential prognostic factor for breast cancer |
title |
The role of Survivin as a biomarker and potential prognostic factor for breast cancer |
spellingShingle |
The role of Survivin as a biomarker and potential prognostic factor for breast cancer Veiga,Glaucia Luciano da Breast Neoplasms Prognosis Neoplasm Metastasis Inhibitor of Apoptosis Proteins |
title_short |
The role of Survivin as a biomarker and potential prognostic factor for breast cancer |
title_full |
The role of Survivin as a biomarker and potential prognostic factor for breast cancer |
title_fullStr |
The role of Survivin as a biomarker and potential prognostic factor for breast cancer |
title_full_unstemmed |
The role of Survivin as a biomarker and potential prognostic factor for breast cancer |
title_sort |
The role of Survivin as a biomarker and potential prognostic factor for breast cancer |
author |
Veiga,Glaucia Luciano da |
author_facet |
Veiga,Glaucia Luciano da Silva,Raissa Daniel Machado da Pereira,Edimar Cristiano Azzalis,Ligia Ajaime Alves,Beatriz da Costa Aguiar Gehrke,Flavia de Sousa Gascón,Thaís Moura Fonseca,Fernando Luiz Affonso |
author_role |
author |
author2 |
Silva,Raissa Daniel Machado da Pereira,Edimar Cristiano Azzalis,Ligia Ajaime Alves,Beatriz da Costa Aguiar Gehrke,Flavia de Sousa Gascón,Thaís Moura Fonseca,Fernando Luiz Affonso |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Veiga,Glaucia Luciano da Silva,Raissa Daniel Machado da Pereira,Edimar Cristiano Azzalis,Ligia Ajaime Alves,Beatriz da Costa Aguiar Gehrke,Flavia de Sousa Gascón,Thaís Moura Fonseca,Fernando Luiz Affonso |
dc.subject.por.fl_str_mv |
Breast Neoplasms Prognosis Neoplasm Metastasis Inhibitor of Apoptosis Proteins |
topic |
Breast Neoplasms Prognosis Neoplasm Metastasis Inhibitor of Apoptosis Proteins |
description |
SUMMARY Breast cancer (BC) is one of the primary health problems worldwide. As the most common cancer in women in the world and in Brasil, behind only non-melanoma skin cancer, this neoplasm corresponds to approximately 28% of new cases per year in the country. BC also affects men, although the incidence corresponds to only 1% of total cases. Currently, most of the chemotherapeutic agents used in BC treatment are extremely toxic and cause long-term side effects. There is also a need to obtain earlier diagnoses, more accurate prognoses and make new therapies available that are more selective and effective in order to improve the current scenario. Therefore, this work sought to evaluate the importance of the biomarker survivin (Sur) in relation to BC, through the detailing of the role of Sur as a biomarker, the correlation between this protein and the prognosis of BC patients, and a summary of therapeutic strategies that target Sur for the development of new anticancer therapies. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000600893 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000600893 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.65.6.893 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.65 n.6 2019 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212834255831040 |