Uremic neuropathy: an overview of the current literature
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200281 |
Resumo: | SUMMARY INTRODUCTION: Peripheral neuropathy is a disorder that affects the cell body, axon or myelin of motor or peripheral sensory neurons and occurs in 60-100% of patients who are submitted to dialysis due to chronic kidney disease. Uremic neuropathy is attributed to the accumulation of organic waste, evident in patients with reduced glomerular filtration rate. Objectives: This review aims to make clinical characteristics of uremic neuropathy evident enabling early diagnosis and treatment. Methods: This is a literature review of articles published on PubMed over the last 10 years using “Uremic Neuropathy” as “Title/Abstract”. Results: A total of nine articles that met the inclusion criteria were included. UN is a distal symmetric sensorimotor polyneuropathy that occurs due to the accumulation of uremic toxins associated with an oxidative stress-related free radical activity. Hyperkalemia is thought to play an important role in its pathophysiology. Diagnosis depends on nerve conduction studies, and treatment includes dialysis or renal transplant. Conclusion: Clinical presentations of UN are broad and non-specific; nonetheless, it is important to detect early changes in order to avoid its progression. The earlier UN is diagnosed and treated, the more successful are the clinical outcomes. |
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Uremic neuropathy: an overview of the current literatureNeural conductionDialysisKidney TransplantationPeripheral Nervous System DiseasesUremia/complicationsSUMMARY INTRODUCTION: Peripheral neuropathy is a disorder that affects the cell body, axon or myelin of motor or peripheral sensory neurons and occurs in 60-100% of patients who are submitted to dialysis due to chronic kidney disease. Uremic neuropathy is attributed to the accumulation of organic waste, evident in patients with reduced glomerular filtration rate. Objectives: This review aims to make clinical characteristics of uremic neuropathy evident enabling early diagnosis and treatment. Methods: This is a literature review of articles published on PubMed over the last 10 years using “Uremic Neuropathy” as “Title/Abstract”. Results: A total of nine articles that met the inclusion criteria were included. UN is a distal symmetric sensorimotor polyneuropathy that occurs due to the accumulation of uremic toxins associated with an oxidative stress-related free radical activity. Hyperkalemia is thought to play an important role in its pathophysiology. Diagnosis depends on nerve conduction studies, and treatment includes dialysis or renal transplant. Conclusion: Clinical presentations of UN are broad and non-specific; nonetheless, it is important to detect early changes in order to avoid its progression. The earlier UN is diagnosed and treated, the more successful are the clinical outcomes.Associação Médica Brasileira2019-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200281Revista da Associação Médica Brasileira v.65 n.2 2019reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.65.2.281info:eu-repo/semantics/openAccessCamargo,Celeste R. deSchoueri,Jean H. M.Alves,Beatriz da Costa AguiarVeiga,Glaucia R. L. daFonseca,Fernando L. A.Bacci,Marcelo R.eng2019-03-15T00:00:00Zoai:scielo:S0104-42302019000200281Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2019-03-15T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Uremic neuropathy: an overview of the current literature |
title |
Uremic neuropathy: an overview of the current literature |
spellingShingle |
Uremic neuropathy: an overview of the current literature Camargo,Celeste R. de Neural conduction Dialysis Kidney Transplantation Peripheral Nervous System Diseases Uremia/complications |
title_short |
Uremic neuropathy: an overview of the current literature |
title_full |
Uremic neuropathy: an overview of the current literature |
title_fullStr |
Uremic neuropathy: an overview of the current literature |
title_full_unstemmed |
Uremic neuropathy: an overview of the current literature |
title_sort |
Uremic neuropathy: an overview of the current literature |
author |
Camargo,Celeste R. de |
author_facet |
Camargo,Celeste R. de Schoueri,Jean H. M. Alves,Beatriz da Costa Aguiar Veiga,Glaucia R. L. da Fonseca,Fernando L. A. Bacci,Marcelo R. |
author_role |
author |
author2 |
Schoueri,Jean H. M. Alves,Beatriz da Costa Aguiar Veiga,Glaucia R. L. da Fonseca,Fernando L. A. Bacci,Marcelo R. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Camargo,Celeste R. de Schoueri,Jean H. M. Alves,Beatriz da Costa Aguiar Veiga,Glaucia R. L. da Fonseca,Fernando L. A. Bacci,Marcelo R. |
dc.subject.por.fl_str_mv |
Neural conduction Dialysis Kidney Transplantation Peripheral Nervous System Diseases Uremia/complications |
topic |
Neural conduction Dialysis Kidney Transplantation Peripheral Nervous System Diseases Uremia/complications |
description |
SUMMARY INTRODUCTION: Peripheral neuropathy is a disorder that affects the cell body, axon or myelin of motor or peripheral sensory neurons and occurs in 60-100% of patients who are submitted to dialysis due to chronic kidney disease. Uremic neuropathy is attributed to the accumulation of organic waste, evident in patients with reduced glomerular filtration rate. Objectives: This review aims to make clinical characteristics of uremic neuropathy evident enabling early diagnosis and treatment. Methods: This is a literature review of articles published on PubMed over the last 10 years using “Uremic Neuropathy” as “Title/Abstract”. Results: A total of nine articles that met the inclusion criteria were included. UN is a distal symmetric sensorimotor polyneuropathy that occurs due to the accumulation of uremic toxins associated with an oxidative stress-related free radical activity. Hyperkalemia is thought to play an important role in its pathophysiology. Diagnosis depends on nerve conduction studies, and treatment includes dialysis or renal transplant. Conclusion: Clinical presentations of UN are broad and non-specific; nonetheless, it is important to detect early changes in order to avoid its progression. The earlier UN is diagnosed and treated, the more successful are the clinical outcomes. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-02-01 |
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info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200281 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200281 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
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10.1590/1806-9282.65.2.281 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
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Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.65 n.2 2019 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
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Associação Médica Brasileira (AMB) |
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Revista da Associação Médica Brasileira (Online) |
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Revista da Associação Médica Brasileira (Online) |
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Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
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