Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacement
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302015000100016 |
Resumo: | Introduction: valve disease is an important cause of heart failure. There is a direct relationship between valve deterioration and the patient’s inflammatory status and cytokines: interleukin-6, interleukin-1, tumor necrosis factor, and C-reactive protein, involved in this major state of inflammation. Objective: to report a series of cases of valve replacement, using a bioprosthetic or mechanical valve, and the inflammatory profile of them. Methods: patients older than 18 years and with bioprosthetic or mechanical valve placed for a minimum of 6 months and maximum of 2 years were included. In addition to the demographic characteristics of each patient, inflammatory markers were measured and a comparison was made of echocardiographic results before (based on medical records) and after surgery. A total of 46 patients were enrolled, 23 with mechanical valve and 23 with bioprosthetic valve. Results: of the 46 patients, 20 presented complete data were included, 12 with bioprosthetic and 8 with mechanical valve. There was no difference between types of prosthesis or implant site for the values of inflammatory markers although they were all above reference range. Discussion: patients undergoing aortic mechanical valve implant benefited more than those undergoing bioprosthetic implant and both with much better results than those of valve replacements performed on mitral valve. In short, there was no difference in relation to inflammatory biomarkers. |
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Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacementinterleukin-6heart failureaortic valve stenosisheart valve prosthesis Introduction: valve disease is an important cause of heart failure. There is a direct relationship between valve deterioration and the patient’s inflammatory status and cytokines: interleukin-6, interleukin-1, tumor necrosis factor, and C-reactive protein, involved in this major state of inflammation. Objective: to report a series of cases of valve replacement, using a bioprosthetic or mechanical valve, and the inflammatory profile of them. Methods: patients older than 18 years and with bioprosthetic or mechanical valve placed for a minimum of 6 months and maximum of 2 years were included. In addition to the demographic characteristics of each patient, inflammatory markers were measured and a comparison was made of echocardiographic results before (based on medical records) and after surgery. A total of 46 patients were enrolled, 23 with mechanical valve and 23 with bioprosthetic valve. Results: of the 46 patients, 20 presented complete data were included, 12 with bioprosthetic and 8 with mechanical valve. There was no difference between types of prosthesis or implant site for the values of inflammatory markers although they were all above reference range. Discussion: patients undergoing aortic mechanical valve implant benefited more than those undergoing bioprosthetic implant and both with much better results than those of valve replacements performed on mitral valve. In short, there was no difference in relation to inflammatory biomarkers. Associação Médica Brasileira2015-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302015000100016Revista da Associação Médica Brasileira v.61 n.1 2015reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.61.01.058info:eu-repo/semantics/openAccessBacci,Marcelo RodriguesMurad,NeifBreda,João RobertoOliveira,Amanda Voltareli Cesar deHerszkowics,NathanCardoso,Nathalia KitamotoFonseca,Fernando Luiz Affonsoeng2015-07-27T00:00:00Zoai:scielo:S0104-42302015000100016Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2015-07-27T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacement |
title |
Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacement |
spellingShingle |
Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacement Bacci,Marcelo Rodrigues interleukin-6 heart failure aortic valve stenosis heart valve prosthesis |
title_short |
Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacement |
title_full |
Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacement |
title_fullStr |
Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacement |
title_full_unstemmed |
Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacement |
title_sort |
Inflammatory biomarker kinetics after mechanical and bioprosthetic valve replacement |
author |
Bacci,Marcelo Rodrigues |
author_facet |
Bacci,Marcelo Rodrigues Murad,Neif Breda,João Roberto Oliveira,Amanda Voltareli Cesar de Herszkowics,Nathan Cardoso,Nathalia Kitamoto Fonseca,Fernando Luiz Affonso |
author_role |
author |
author2 |
Murad,Neif Breda,João Roberto Oliveira,Amanda Voltareli Cesar de Herszkowics,Nathan Cardoso,Nathalia Kitamoto Fonseca,Fernando Luiz Affonso |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Bacci,Marcelo Rodrigues Murad,Neif Breda,João Roberto Oliveira,Amanda Voltareli Cesar de Herszkowics,Nathan Cardoso,Nathalia Kitamoto Fonseca,Fernando Luiz Affonso |
dc.subject.por.fl_str_mv |
interleukin-6 heart failure aortic valve stenosis heart valve prosthesis |
topic |
interleukin-6 heart failure aortic valve stenosis heart valve prosthesis |
description |
Introduction: valve disease is an important cause of heart failure. There is a direct relationship between valve deterioration and the patient’s inflammatory status and cytokines: interleukin-6, interleukin-1, tumor necrosis factor, and C-reactive protein, involved in this major state of inflammation. Objective: to report a series of cases of valve replacement, using a bioprosthetic or mechanical valve, and the inflammatory profile of them. Methods: patients older than 18 years and with bioprosthetic or mechanical valve placed for a minimum of 6 months and maximum of 2 years were included. In addition to the demographic characteristics of each patient, inflammatory markers were measured and a comparison was made of echocardiographic results before (based on medical records) and after surgery. A total of 46 patients were enrolled, 23 with mechanical valve and 23 with bioprosthetic valve. Results: of the 46 patients, 20 presented complete data were included, 12 with bioprosthetic and 8 with mechanical valve. There was no difference between types of prosthesis or implant site for the values of inflammatory markers although they were all above reference range. Discussion: patients undergoing aortic mechanical valve implant benefited more than those undergoing bioprosthetic implant and both with much better results than those of valve replacements performed on mitral valve. In short, there was no difference in relation to inflammatory biomarkers. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-02-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302015000100016 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302015000100016 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.61.01.058 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.61 n.1 2015 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
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AMB |
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AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212831488638976 |