Th1 and Th2 immune responses related to pelvic endometriosis

Detalhes bibliográficos
Autor(a) principal: Podgaec,Sergio
Data de Publicação: 2010
Outros Autores: Dias Junior,João Antonio, Chapron,Charles, Oliveira,Ricardo Manoel de, Baracat,Edmund Chada, Abrão,Maurício Simões
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302010000100022
Resumo: OBJECTIVE: This study analyzed the relationship between clinical characteristics of endometriosis and Th1/Th2 immune response patterns. METHODS: A prospective study was performed with 65 patients with endometriosis (Group A) and 33 without the disease (Group B). Measurement of IL 2, 4 and 10, TNF-alpha and IFN-gamma was carried out in peripheral blood and peritoneal fluid. RESULTS: Serum TNF-alpha was higher in patients with endometriosis who had deep dyspareunia compared to controls (mean 4.5 pg/ml and 2.3 pg/ml, p<0.05). Among these patients (n=32), 65.5% had deep endometriosis. Patients with endometriosis and infertility had higher IL-2 concentrations in peritoneal fluid than controls (mean 5.9 pg/ml and 0.2 pg/ml, p<0.05). Among these patients (n=22), 63.5% (n=14) had deep endometriosis. A higher concentration of IL-10 was also observed in patients with ovarian endometriosis when compared to those without this type of disease, as well as when compared to control group patients (mean 50pg/ml, 18.7pg/ml and 25.7pg/ml, p<0.05). CONCLUSIONS: These results suggest that when specific clinical data are associated with a higher production of certain cytokines, there is a Th1 response pattern that may be related to deep infiltrating endometriosis.
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spelling Th1 and Th2 immune responses related to pelvic endometriosisEndometriosisAllergy and ImmunologyCytokinesTh1 CellsTh2 CellsOBJECTIVE: This study analyzed the relationship between clinical characteristics of endometriosis and Th1/Th2 immune response patterns. METHODS: A prospective study was performed with 65 patients with endometriosis (Group A) and 33 without the disease (Group B). Measurement of IL 2, 4 and 10, TNF-alpha and IFN-gamma was carried out in peripheral blood and peritoneal fluid. RESULTS: Serum TNF-alpha was higher in patients with endometriosis who had deep dyspareunia compared to controls (mean 4.5 pg/ml and 2.3 pg/ml, p<0.05). Among these patients (n=32), 65.5% had deep endometriosis. Patients with endometriosis and infertility had higher IL-2 concentrations in peritoneal fluid than controls (mean 5.9 pg/ml and 0.2 pg/ml, p<0.05). Among these patients (n=22), 63.5% (n=14) had deep endometriosis. A higher concentration of IL-10 was also observed in patients with ovarian endometriosis when compared to those without this type of disease, as well as when compared to control group patients (mean 50pg/ml, 18.7pg/ml and 25.7pg/ml, p<0.05). CONCLUSIONS: These results suggest that when specific clinical data are associated with a higher production of certain cytokines, there is a Th1 response pattern that may be related to deep infiltrating endometriosis.Associação Médica Brasileira2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302010000100022Revista da Associação Médica Brasileira v.56 n.1 2010reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/S0104-42302010000100022info:eu-repo/semantics/openAccessPodgaec,SergioDias Junior,João AntonioChapron,CharlesOliveira,Ricardo Manoel deBaracat,Edmund ChadaAbrão,Maurício Simõeseng2010-04-27T00:00:00Zoai:scielo:S0104-42302010000100022Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2010-04-27T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Th1 and Th2 immune responses related to pelvic endometriosis
title Th1 and Th2 immune responses related to pelvic endometriosis
spellingShingle Th1 and Th2 immune responses related to pelvic endometriosis
Podgaec,Sergio
Endometriosis
Allergy and Immunology
Cytokines
Th1 Cells
Th2 Cells
title_short Th1 and Th2 immune responses related to pelvic endometriosis
title_full Th1 and Th2 immune responses related to pelvic endometriosis
title_fullStr Th1 and Th2 immune responses related to pelvic endometriosis
title_full_unstemmed Th1 and Th2 immune responses related to pelvic endometriosis
title_sort Th1 and Th2 immune responses related to pelvic endometriosis
author Podgaec,Sergio
author_facet Podgaec,Sergio
Dias Junior,João Antonio
Chapron,Charles
Oliveira,Ricardo Manoel de
Baracat,Edmund Chada
Abrão,Maurício Simões
author_role author
author2 Dias Junior,João Antonio
Chapron,Charles
Oliveira,Ricardo Manoel de
Baracat,Edmund Chada
Abrão,Maurício Simões
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Podgaec,Sergio
Dias Junior,João Antonio
Chapron,Charles
Oliveira,Ricardo Manoel de
Baracat,Edmund Chada
Abrão,Maurício Simões
dc.subject.por.fl_str_mv Endometriosis
Allergy and Immunology
Cytokines
Th1 Cells
Th2 Cells
topic Endometriosis
Allergy and Immunology
Cytokines
Th1 Cells
Th2 Cells
description OBJECTIVE: This study analyzed the relationship between clinical characteristics of endometriosis and Th1/Th2 immune response patterns. METHODS: A prospective study was performed with 65 patients with endometriosis (Group A) and 33 without the disease (Group B). Measurement of IL 2, 4 and 10, TNF-alpha and IFN-gamma was carried out in peripheral blood and peritoneal fluid. RESULTS: Serum TNF-alpha was higher in patients with endometriosis who had deep dyspareunia compared to controls (mean 4.5 pg/ml and 2.3 pg/ml, p<0.05). Among these patients (n=32), 65.5% had deep endometriosis. Patients with endometriosis and infertility had higher IL-2 concentrations in peritoneal fluid than controls (mean 5.9 pg/ml and 0.2 pg/ml, p<0.05). Among these patients (n=22), 63.5% (n=14) had deep endometriosis. A higher concentration of IL-10 was also observed in patients with ovarian endometriosis when compared to those without this type of disease, as well as when compared to control group patients (mean 50pg/ml, 18.7pg/ml and 25.7pg/ml, p<0.05). CONCLUSIONS: These results suggest that when specific clinical data are associated with a higher production of certain cytokines, there is a Th1 response pattern that may be related to deep infiltrating endometriosis.
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 10.1590/S0104-42302010000100022
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dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.56 n.1 2010
reponame:Revista da Associação Médica Brasileira (Online)
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repository.name.fl_str_mv Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)
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