Melatonin effects on ovarian follicular cells: a systematic review

Detalhes bibliográficos
Autor(a) principal: Minguini,Isabela Pasqualini
Data de Publicação: 2019
Outros Autores: Luquetti,Camila Maganhin, Baracat,Maria Cândida Pinheiro, Maganhin,Carla Cristina, Nunes,Camila de Oliveira, Simões,Ricardo Santos, Veiga,Eduardo Carvalho de Arruda, Cipolla Neto,José, Baracat,Edmund Chada, Soares Junior,Jose Maria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista da Associação Médica Brasileira (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000801122
Resumo: SUMMARY Melatonin is known for its effects on both the sleep and reproductive system of mammals. The latter has melatonin receptors type 1 and 2, which act to regulate, among other things, cyclic AMP. Notwithstanding all the literature data, there is still no sound knowledge or a clear understanding of the hormone’s action on the physiology of ovarian follicular cells. OBJECTIVE To review and evaluate studies about melatonin action on the ovarian granulosa/theca interna cells from the literature. METHODS The systematic review was carried out according to the PRISMA recommendations. The MEDLINE and Cochrane primary databases were consulted with the use of specific terms. There was no limitation on language or publication year. RESULTS Seven papers about melatonin action on granulosa cells were selected. The following can be attributed to the hormone’s effects: a) progesterone increase in culture medium; b) increased estrogen production; c) antagonistic action on estrogen; d) improvement in cell quality resulting in improved embryo and higher pregnancy rates; e) improved cell proliferation via MAPK; f) reduction of free radicals. Nevertheless, there are contrarian papers reporting a reduction in progesterone production. CONCLUSION Melatonin interferes in sex steroid production, boosting progesterone output. Such action may help improve oocyte quality.
id AMB-1_e2b5184092d66ee7731fac79de49ff18
oai_identifier_str oai:scielo:S0104-42302019000801122
network_acronym_str AMB-1
network_name_str Revista da Associação Médica Brasileira (Online)
repository_id_str
spelling Melatonin effects on ovarian follicular cells: a systematic reviewMelatoninOvaryGranulosa cellsSUMMARY Melatonin is known for its effects on both the sleep and reproductive system of mammals. The latter has melatonin receptors type 1 and 2, which act to regulate, among other things, cyclic AMP. Notwithstanding all the literature data, there is still no sound knowledge or a clear understanding of the hormone’s action on the physiology of ovarian follicular cells. OBJECTIVE To review and evaluate studies about melatonin action on the ovarian granulosa/theca interna cells from the literature. METHODS The systematic review was carried out according to the PRISMA recommendations. The MEDLINE and Cochrane primary databases were consulted with the use of specific terms. There was no limitation on language or publication year. RESULTS Seven papers about melatonin action on granulosa cells were selected. The following can be attributed to the hormone’s effects: a) progesterone increase in culture medium; b) increased estrogen production; c) antagonistic action on estrogen; d) improvement in cell quality resulting in improved embryo and higher pregnancy rates; e) improved cell proliferation via MAPK; f) reduction of free radicals. Nevertheless, there are contrarian papers reporting a reduction in progesterone production. CONCLUSION Melatonin interferes in sex steroid production, boosting progesterone output. Such action may help improve oocyte quality.Associação Médica Brasileira2019-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000801122Revista da Associação Médica Brasileira v.65 n.8 2019reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.65.8.1122info:eu-repo/semantics/openAccessMinguini,Isabela PasqualiniLuquetti,Camila MaganhinBaracat,Maria Cândida PinheiroMaganhin,Carla CristinaNunes,Camila de OliveiraSimões,Ricardo SantosVeiga,Eduardo Carvalho de ArrudaCipolla Neto,JoséBaracat,Edmund ChadaSoares Junior,Jose Mariaeng2020-01-20T00:00:00Zoai:scielo:S0104-42302019000801122Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2020-01-20T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false
dc.title.none.fl_str_mv Melatonin effects on ovarian follicular cells: a systematic review
title Melatonin effects on ovarian follicular cells: a systematic review
spellingShingle Melatonin effects on ovarian follicular cells: a systematic review
Minguini,Isabela Pasqualini
Melatonin
Ovary
Granulosa cells
title_short Melatonin effects on ovarian follicular cells: a systematic review
title_full Melatonin effects on ovarian follicular cells: a systematic review
title_fullStr Melatonin effects on ovarian follicular cells: a systematic review
title_full_unstemmed Melatonin effects on ovarian follicular cells: a systematic review
title_sort Melatonin effects on ovarian follicular cells: a systematic review
author Minguini,Isabela Pasqualini
author_facet Minguini,Isabela Pasqualini
Luquetti,Camila Maganhin
Baracat,Maria Cândida Pinheiro
Maganhin,Carla Cristina
Nunes,Camila de Oliveira
Simões,Ricardo Santos
Veiga,Eduardo Carvalho de Arruda
Cipolla Neto,José
Baracat,Edmund Chada
Soares Junior,Jose Maria
author_role author
author2 Luquetti,Camila Maganhin
Baracat,Maria Cândida Pinheiro
Maganhin,Carla Cristina
Nunes,Camila de Oliveira
Simões,Ricardo Santos
Veiga,Eduardo Carvalho de Arruda
Cipolla Neto,José
Baracat,Edmund Chada
Soares Junior,Jose Maria
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Minguini,Isabela Pasqualini
Luquetti,Camila Maganhin
Baracat,Maria Cândida Pinheiro
Maganhin,Carla Cristina
Nunes,Camila de Oliveira
Simões,Ricardo Santos
Veiga,Eduardo Carvalho de Arruda
Cipolla Neto,José
Baracat,Edmund Chada
Soares Junior,Jose Maria
dc.subject.por.fl_str_mv Melatonin
Ovary
Granulosa cells
topic Melatonin
Ovary
Granulosa cells
description SUMMARY Melatonin is known for its effects on both the sleep and reproductive system of mammals. The latter has melatonin receptors type 1 and 2, which act to regulate, among other things, cyclic AMP. Notwithstanding all the literature data, there is still no sound knowledge or a clear understanding of the hormone’s action on the physiology of ovarian follicular cells. OBJECTIVE To review and evaluate studies about melatonin action on the ovarian granulosa/theca interna cells from the literature. METHODS The systematic review was carried out according to the PRISMA recommendations. The MEDLINE and Cochrane primary databases were consulted with the use of specific terms. There was no limitation on language or publication year. RESULTS Seven papers about melatonin action on granulosa cells were selected. The following can be attributed to the hormone’s effects: a) progesterone increase in culture medium; b) increased estrogen production; c) antagonistic action on estrogen; d) improvement in cell quality resulting in improved embryo and higher pregnancy rates; e) improved cell proliferation via MAPK; f) reduction of free radicals. Nevertheless, there are contrarian papers reporting a reduction in progesterone production. CONCLUSION Melatonin interferes in sex steroid production, boosting progesterone output. Such action may help improve oocyte quality.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000801122
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000801122
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1806-9282.65.8.1122
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Médica Brasileira
publisher.none.fl_str_mv Associação Médica Brasileira
dc.source.none.fl_str_mv Revista da Associação Médica Brasileira v.65 n.8 2019
reponame:Revista da Associação Médica Brasileira (Online)
instname:Associação Médica Brasileira (AMB)
instacron:AMB
instname_str Associação Médica Brasileira (AMB)
instacron_str AMB
institution AMB
reponame_str Revista da Associação Médica Brasileira (Online)
collection Revista da Associação Médica Brasileira (Online)
repository.name.fl_str_mv Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)
repository.mail.fl_str_mv ||ramb@amb.org.br
_version_ 1754212834307211264