Melatonin effects on ovarian follicular cells: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista da Associação Médica Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000801122 |
Resumo: | SUMMARY Melatonin is known for its effects on both the sleep and reproductive system of mammals. The latter has melatonin receptors type 1 and 2, which act to regulate, among other things, cyclic AMP. Notwithstanding all the literature data, there is still no sound knowledge or a clear understanding of the hormone’s action on the physiology of ovarian follicular cells. OBJECTIVE To review and evaluate studies about melatonin action on the ovarian granulosa/theca interna cells from the literature. METHODS The systematic review was carried out according to the PRISMA recommendations. The MEDLINE and Cochrane primary databases were consulted with the use of specific terms. There was no limitation on language or publication year. RESULTS Seven papers about melatonin action on granulosa cells were selected. The following can be attributed to the hormone’s effects: a) progesterone increase in culture medium; b) increased estrogen production; c) antagonistic action on estrogen; d) improvement in cell quality resulting in improved embryo and higher pregnancy rates; e) improved cell proliferation via MAPK; f) reduction of free radicals. Nevertheless, there are contrarian papers reporting a reduction in progesterone production. CONCLUSION Melatonin interferes in sex steroid production, boosting progesterone output. Such action may help improve oocyte quality. |
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Melatonin effects on ovarian follicular cells: a systematic reviewMelatoninOvaryGranulosa cellsSUMMARY Melatonin is known for its effects on both the sleep and reproductive system of mammals. The latter has melatonin receptors type 1 and 2, which act to regulate, among other things, cyclic AMP. Notwithstanding all the literature data, there is still no sound knowledge or a clear understanding of the hormone’s action on the physiology of ovarian follicular cells. OBJECTIVE To review and evaluate studies about melatonin action on the ovarian granulosa/theca interna cells from the literature. METHODS The systematic review was carried out according to the PRISMA recommendations. The MEDLINE and Cochrane primary databases were consulted with the use of specific terms. There was no limitation on language or publication year. RESULTS Seven papers about melatonin action on granulosa cells were selected. The following can be attributed to the hormone’s effects: a) progesterone increase in culture medium; b) increased estrogen production; c) antagonistic action on estrogen; d) improvement in cell quality resulting in improved embryo and higher pregnancy rates; e) improved cell proliferation via MAPK; f) reduction of free radicals. Nevertheless, there are contrarian papers reporting a reduction in progesterone production. CONCLUSION Melatonin interferes in sex steroid production, boosting progesterone output. Such action may help improve oocyte quality.Associação Médica Brasileira2019-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000801122Revista da Associação Médica Brasileira v.65 n.8 2019reponame:Revista da Associação Médica Brasileira (Online)instname:Associação Médica Brasileira (AMB)instacron:AMB10.1590/1806-9282.65.8.1122info:eu-repo/semantics/openAccessMinguini,Isabela PasqualiniLuquetti,Camila MaganhinBaracat,Maria Cândida PinheiroMaganhin,Carla CristinaNunes,Camila de OliveiraSimões,Ricardo SantosVeiga,Eduardo Carvalho de ArrudaCipolla Neto,JoséBaracat,Edmund ChadaSoares Junior,Jose Mariaeng2020-01-20T00:00:00Zoai:scielo:S0104-42302019000801122Revistahttps://ramb.amb.org.br/ultimas-edicoes/#https://old.scielo.br/oai/scielo-oai.php||ramb@amb.org.br1806-92820104-4230opendoar:2020-01-20T00:00Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB)false |
dc.title.none.fl_str_mv |
Melatonin effects on ovarian follicular cells: a systematic review |
title |
Melatonin effects on ovarian follicular cells: a systematic review |
spellingShingle |
Melatonin effects on ovarian follicular cells: a systematic review Minguini,Isabela Pasqualini Melatonin Ovary Granulosa cells |
title_short |
Melatonin effects on ovarian follicular cells: a systematic review |
title_full |
Melatonin effects on ovarian follicular cells: a systematic review |
title_fullStr |
Melatonin effects on ovarian follicular cells: a systematic review |
title_full_unstemmed |
Melatonin effects on ovarian follicular cells: a systematic review |
title_sort |
Melatonin effects on ovarian follicular cells: a systematic review |
author |
Minguini,Isabela Pasqualini |
author_facet |
Minguini,Isabela Pasqualini Luquetti,Camila Maganhin Baracat,Maria Cândida Pinheiro Maganhin,Carla Cristina Nunes,Camila de Oliveira Simões,Ricardo Santos Veiga,Eduardo Carvalho de Arruda Cipolla Neto,José Baracat,Edmund Chada Soares Junior,Jose Maria |
author_role |
author |
author2 |
Luquetti,Camila Maganhin Baracat,Maria Cândida Pinheiro Maganhin,Carla Cristina Nunes,Camila de Oliveira Simões,Ricardo Santos Veiga,Eduardo Carvalho de Arruda Cipolla Neto,José Baracat,Edmund Chada Soares Junior,Jose Maria |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Minguini,Isabela Pasqualini Luquetti,Camila Maganhin Baracat,Maria Cândida Pinheiro Maganhin,Carla Cristina Nunes,Camila de Oliveira Simões,Ricardo Santos Veiga,Eduardo Carvalho de Arruda Cipolla Neto,José Baracat,Edmund Chada Soares Junior,Jose Maria |
dc.subject.por.fl_str_mv |
Melatonin Ovary Granulosa cells |
topic |
Melatonin Ovary Granulosa cells |
description |
SUMMARY Melatonin is known for its effects on both the sleep and reproductive system of mammals. The latter has melatonin receptors type 1 and 2, which act to regulate, among other things, cyclic AMP. Notwithstanding all the literature data, there is still no sound knowledge or a clear understanding of the hormone’s action on the physiology of ovarian follicular cells. OBJECTIVE To review and evaluate studies about melatonin action on the ovarian granulosa/theca interna cells from the literature. METHODS The systematic review was carried out according to the PRISMA recommendations. The MEDLINE and Cochrane primary databases were consulted with the use of specific terms. There was no limitation on language or publication year. RESULTS Seven papers about melatonin action on granulosa cells were selected. The following can be attributed to the hormone’s effects: a) progesterone increase in culture medium; b) increased estrogen production; c) antagonistic action on estrogen; d) improvement in cell quality resulting in improved embryo and higher pregnancy rates; e) improved cell proliferation via MAPK; f) reduction of free radicals. Nevertheless, there are contrarian papers reporting a reduction in progesterone production. CONCLUSION Melatonin interferes in sex steroid production, boosting progesterone output. Such action may help improve oocyte quality. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000801122 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000801122 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1806-9282.65.8.1122 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Médica Brasileira |
publisher.none.fl_str_mv |
Associação Médica Brasileira |
dc.source.none.fl_str_mv |
Revista da Associação Médica Brasileira v.65 n.8 2019 reponame:Revista da Associação Médica Brasileira (Online) instname:Associação Médica Brasileira (AMB) instacron:AMB |
instname_str |
Associação Médica Brasileira (AMB) |
instacron_str |
AMB |
institution |
AMB |
reponame_str |
Revista da Associação Médica Brasileira (Online) |
collection |
Revista da Associação Médica Brasileira (Online) |
repository.name.fl_str_mv |
Revista da Associação Médica Brasileira (Online) - Associação Médica Brasileira (AMB) |
repository.mail.fl_str_mv |
||ramb@amb.org.br |
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1754212834307211264 |