Partitioning evolutive standard base excess determinants in septic shock patients
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista brasileira de terapia intensiva (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2007000400006 |
Resumo: | BACKGROUND AND OBJECTIVES: The amount of metabolic acidosis measured through the standard base excess (SBE) has been shown to be an outcome marker and its improvement has been associated with better survival. We studied the mechanism of standard base excess variation in the first three days of intensive care unit (ICU) stay through the evaluation of independent variables of physico-chemical approach. METHODS: Data were retrieved from our prospective collected data base from patients with diagnosis of septic shock, daily up to the third day after the ICU admission. Single correlations between SBE and independent variables were performed as well as a mathematical multilinear model was built to disclose the SBE variation determinants. RESULTS: We have shown that in septic shock patients the standard base excess variation during the first three days of ICU stay is weakly correlated to strong ion gap (SIG), lactate, creatinin and PaCO2 when individually analyzed. Analyzing concomitantly those independent variables, we built a mathematical model with a stepwise multilinear regression composed by apparent strong ion difference (SIDa), SIG, PaCO2, albumin and diuresis that resulted in a R² coefficient of 0.866 to determine SBE variation. CONCLUSIONS: Variations of metabolic acidosis measured through the standard base excess in septic shock patients when analyzed until the third day after intensive care unit admission, is resultant of interaction of several independent determinants as PaCO2, diuresis, SIG, SIDa and albumin. |
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Partitioning evolutive standard base excess determinants in septic shock patientslactatemetabolic acidosismonitorizationseptic shocksevere sepsisBACKGROUND AND OBJECTIVES: The amount of metabolic acidosis measured through the standard base excess (SBE) has been shown to be an outcome marker and its improvement has been associated with better survival. We studied the mechanism of standard base excess variation in the first three days of intensive care unit (ICU) stay through the evaluation of independent variables of physico-chemical approach. METHODS: Data were retrieved from our prospective collected data base from patients with diagnosis of septic shock, daily up to the third day after the ICU admission. Single correlations between SBE and independent variables were performed as well as a mathematical multilinear model was built to disclose the SBE variation determinants. RESULTS: We have shown that in septic shock patients the standard base excess variation during the first three days of ICU stay is weakly correlated to strong ion gap (SIG), lactate, creatinin and PaCO2 when individually analyzed. Analyzing concomitantly those independent variables, we built a mathematical model with a stepwise multilinear regression composed by apparent strong ion difference (SIDa), SIG, PaCO2, albumin and diuresis that resulted in a R² coefficient of 0.866 to determine SBE variation. CONCLUSIONS: Variations of metabolic acidosis measured through the standard base excess in septic shock patients when analyzed until the third day after intensive care unit admission, is resultant of interaction of several independent determinants as PaCO2, diuresis, SIG, SIDa and albumin.Associação de Medicina Intensiva Brasileira - AMIB2007-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2007000400006Revista Brasileira de Terapia Intensiva v.19 n.4 2007reponame:Revista brasileira de terapia intensiva (Online)instname:Associação de Medicina Intensiva Brasileira (AMIB)instacron:AMIB10.1590/S0103-507X2007000400006info:eu-repo/semantics/openAccessPark,MarceloNoritomi,Danilo TeixeiraToledo-Maciel,AlexandreAzevedo,Luciano Cesar Pontes dePizzo,Vladimir RibeiroCruz-Neto,Luiz Monteiro daeng2008-01-31T00:00:00Zoai:scielo:S0103-507X2007000400006Revistahttp://www.scielo.br/rbtihttps://old.scielo.br/oai/scielo-oai.phpdiretoria@amib.org.br||rbti.artigos@amib.org.br1982-43350103-507Xopendoar:2008-01-31T00:00Revista brasileira de terapia intensiva (Online) - Associação de Medicina Intensiva Brasileira (AMIB)false |
dc.title.none.fl_str_mv |
Partitioning evolutive standard base excess determinants in septic shock patients |
title |
Partitioning evolutive standard base excess determinants in septic shock patients |
spellingShingle |
Partitioning evolutive standard base excess determinants in septic shock patients Park,Marcelo lactate metabolic acidosis monitorization septic shock severe sepsis |
title_short |
Partitioning evolutive standard base excess determinants in septic shock patients |
title_full |
Partitioning evolutive standard base excess determinants in septic shock patients |
title_fullStr |
Partitioning evolutive standard base excess determinants in septic shock patients |
title_full_unstemmed |
Partitioning evolutive standard base excess determinants in septic shock patients |
title_sort |
Partitioning evolutive standard base excess determinants in septic shock patients |
author |
Park,Marcelo |
author_facet |
Park,Marcelo Noritomi,Danilo Teixeira Toledo-Maciel,Alexandre Azevedo,Luciano Cesar Pontes de Pizzo,Vladimir Ribeiro Cruz-Neto,Luiz Monteiro da |
author_role |
author |
author2 |
Noritomi,Danilo Teixeira Toledo-Maciel,Alexandre Azevedo,Luciano Cesar Pontes de Pizzo,Vladimir Ribeiro Cruz-Neto,Luiz Monteiro da |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Park,Marcelo Noritomi,Danilo Teixeira Toledo-Maciel,Alexandre Azevedo,Luciano Cesar Pontes de Pizzo,Vladimir Ribeiro Cruz-Neto,Luiz Monteiro da |
dc.subject.por.fl_str_mv |
lactate metabolic acidosis monitorization septic shock severe sepsis |
topic |
lactate metabolic acidosis monitorization septic shock severe sepsis |
description |
BACKGROUND AND OBJECTIVES: The amount of metabolic acidosis measured through the standard base excess (SBE) has been shown to be an outcome marker and its improvement has been associated with better survival. We studied the mechanism of standard base excess variation in the first three days of intensive care unit (ICU) stay through the evaluation of independent variables of physico-chemical approach. METHODS: Data were retrieved from our prospective collected data base from patients with diagnosis of septic shock, daily up to the third day after the ICU admission. Single correlations between SBE and independent variables were performed as well as a mathematical multilinear model was built to disclose the SBE variation determinants. RESULTS: We have shown that in septic shock patients the standard base excess variation during the first three days of ICU stay is weakly correlated to strong ion gap (SIG), lactate, creatinin and PaCO2 when individually analyzed. Analyzing concomitantly those independent variables, we built a mathematical model with a stepwise multilinear regression composed by apparent strong ion difference (SIDa), SIG, PaCO2, albumin and diuresis that resulted in a R² coefficient of 0.866 to determine SBE variation. CONCLUSIONS: Variations of metabolic acidosis measured through the standard base excess in septic shock patients when analyzed until the third day after intensive care unit admission, is resultant of interaction of several independent determinants as PaCO2, diuresis, SIG, SIDa and albumin. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2007000400006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2007000400006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-507X2007000400006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação de Medicina Intensiva Brasileira - AMIB |
publisher.none.fl_str_mv |
Associação de Medicina Intensiva Brasileira - AMIB |
dc.source.none.fl_str_mv |
Revista Brasileira de Terapia Intensiva v.19 n.4 2007 reponame:Revista brasileira de terapia intensiva (Online) instname:Associação de Medicina Intensiva Brasileira (AMIB) instacron:AMIB |
instname_str |
Associação de Medicina Intensiva Brasileira (AMIB) |
instacron_str |
AMIB |
institution |
AMIB |
reponame_str |
Revista brasileira de terapia intensiva (Online) |
collection |
Revista brasileira de terapia intensiva (Online) |
repository.name.fl_str_mv |
Revista brasileira de terapia intensiva (Online) - Associação de Medicina Intensiva Brasileira (AMIB) |
repository.mail.fl_str_mv |
diretoria@amib.org.br||rbti.artigos@amib.org.br |
_version_ |
1754212856602034176 |