Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration

Detalhes bibliográficos
Autor(a) principal: Onyike,Chiadi U.
Data de Publicação: 2013
Outros Autores: Pletnikova,Olga, Sloane,Kelly L., Sullivan,Campbell, Troncoso,Juan C., Rabins,Peter V.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000100083
Resumo: ABSTRACT Objective: To describe characteristics of hippocampal sclerosis dementia. Methods: Convenience sample of Hippocampal sclerosis dementia (HSD) recruited from the Johns Hopkins University Brain Resource Center. Twenty-four cases with post-mortem pathological diagnosis of hippocampal sclerosis dementia were reviewed for clinical characterization. Results: The cases showed atrophy and neuronal loss localized to the hippocampus, amygdala and entorrhinal cortex. The majority (79.2%) had amnesia at illness onset, and many (54.2%) showed abnormal conduct and psychiatric disorder. Nearly 42% presented with an amnesic state, and 37.5% presented with amnesia plus abnormal conduct and psychiatric disorder. All eventually developed a behavioral or psychiatric disorder. Disorientation, executive dysfunction, aphasia, agnosia and apraxia were uncommon at onset. Alzheimer disease (AD) was the initial clinical diagnosis in 89% and the final clinical diagnosis in 75%. Diagnosis of frontotemporal dementia (FTD) was uncommon (seen in 8%). Conclusion: HSD shows pathological characteristics of FTD and clinical features that mimic AD and overlap with FTD. The findings, placed in the context of earlier work, support the proposition that HSD belongs to the FTD family, where it may be identified as an amnesic variant.
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spelling Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degenerationdementia classificationhippocampal sclerosisfrontotemporal dementianeuropsychiatryABSTRACT Objective: To describe characteristics of hippocampal sclerosis dementia. Methods: Convenience sample of Hippocampal sclerosis dementia (HSD) recruited from the Johns Hopkins University Brain Resource Center. Twenty-four cases with post-mortem pathological diagnosis of hippocampal sclerosis dementia were reviewed for clinical characterization. Results: The cases showed atrophy and neuronal loss localized to the hippocampus, amygdala and entorrhinal cortex. The majority (79.2%) had amnesia at illness onset, and many (54.2%) showed abnormal conduct and psychiatric disorder. Nearly 42% presented with an amnesic state, and 37.5% presented with amnesia plus abnormal conduct and psychiatric disorder. All eventually developed a behavioral or psychiatric disorder. Disorientation, executive dysfunction, aphasia, agnosia and apraxia were uncommon at onset. Alzheimer disease (AD) was the initial clinical diagnosis in 89% and the final clinical diagnosis in 75%. Diagnosis of frontotemporal dementia (FTD) was uncommon (seen in 8%). Conclusion: HSD shows pathological characteristics of FTD and clinical features that mimic AD and overlap with FTD. The findings, placed in the context of earlier work, support the proposition that HSD belongs to the FTD family, where it may be identified as an amnesic variant.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2013-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000100083Dementia & Neuropsychologia v.7 n.1 2013reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642013DN70100013info:eu-repo/semantics/openAccessOnyike,Chiadi U.Pletnikova,OlgaSloane,Kelly L.Sullivan,CampbellTroncoso,Juan C.Rabins,Peter V.eng2016-06-16T00:00:00Zoai:scielo:S1980-57642013000100083Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-06-16T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration
title Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration
spellingShingle Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration
Onyike,Chiadi U.
dementia classification
hippocampal sclerosis
frontotemporal dementia
neuropsychiatry
title_short Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration
title_full Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration
title_fullStr Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration
title_full_unstemmed Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration
title_sort Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration
author Onyike,Chiadi U.
author_facet Onyike,Chiadi U.
Pletnikova,Olga
Sloane,Kelly L.
Sullivan,Campbell
Troncoso,Juan C.
Rabins,Peter V.
author_role author
author2 Pletnikova,Olga
Sloane,Kelly L.
Sullivan,Campbell
Troncoso,Juan C.
Rabins,Peter V.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Onyike,Chiadi U.
Pletnikova,Olga
Sloane,Kelly L.
Sullivan,Campbell
Troncoso,Juan C.
Rabins,Peter V.
dc.subject.por.fl_str_mv dementia classification
hippocampal sclerosis
frontotemporal dementia
neuropsychiatry
topic dementia classification
hippocampal sclerosis
frontotemporal dementia
neuropsychiatry
description ABSTRACT Objective: To describe characteristics of hippocampal sclerosis dementia. Methods: Convenience sample of Hippocampal sclerosis dementia (HSD) recruited from the Johns Hopkins University Brain Resource Center. Twenty-four cases with post-mortem pathological diagnosis of hippocampal sclerosis dementia were reviewed for clinical characterization. Results: The cases showed atrophy and neuronal loss localized to the hippocampus, amygdala and entorrhinal cortex. The majority (79.2%) had amnesia at illness onset, and many (54.2%) showed abnormal conduct and psychiatric disorder. Nearly 42% presented with an amnesic state, and 37.5% presented with amnesia plus abnormal conduct and psychiatric disorder. All eventually developed a behavioral or psychiatric disorder. Disorientation, executive dysfunction, aphasia, agnosia and apraxia were uncommon at onset. Alzheimer disease (AD) was the initial clinical diagnosis in 89% and the final clinical diagnosis in 75%. Diagnosis of frontotemporal dementia (FTD) was uncommon (seen in 8%). Conclusion: HSD shows pathological characteristics of FTD and clinical features that mimic AD and overlap with FTD. The findings, placed in the context of earlier work, support the proposition that HSD belongs to the FTD family, where it may be identified as an amnesic variant.
publishDate 2013
dc.date.none.fl_str_mv 2013-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000100083
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642013000100083
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1980-57642013DN70100013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.7 n.1 2013
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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