Cognitive impairment in bipolar disorder Neuroprogression or behavioral variant frontotemporal dementia?
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Dementia & Neuropsychologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000400475 |
Resumo: | ABSTRACT Patients with Bipolar Disorder (BD) usually display cognitive deficits with aging. However, the correlation between BD and dementia syndromes is inconclusive, despite the similarity with behavioral variant frontotemporal dementia. We report a 78-year-old female patient who had bipolar type 1 disorder since adolescence. Her symptoms ranged from apathy to psychotic mania. She had had three hospitalizations, and since her last stay 10 years ago, her symptoms had remained stable. However, in the past 2 years, she displayed different symptoms, such as irritability manifested as verbal and physical aggression, cognitive impairment, repetitive pattern of behavior, perambulation, persecutory delusions, disorientation, and hyporexia. Treatment with anticholinesterases or mood stabilizers promoted no improvement. She scored 17/30 points on the Mini-Mental State Examination. Neuropsychological assessment suggested deficits in executive function, attention, and memory. Neuroimaging tests revealed frontotemporal degeneration and hypoperfusion. Diagnostic and therapeutic approaches for this type of patient represent a significant challenge for clinicians. |
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Cognitive impairment in bipolar disorder Neuroprogression or behavioral variant frontotemporal dementia?bipolar disorderfrontotemporal dementiageriatric neuropsychiatryneuroprogressionABSTRACT Patients with Bipolar Disorder (BD) usually display cognitive deficits with aging. However, the correlation between BD and dementia syndromes is inconclusive, despite the similarity with behavioral variant frontotemporal dementia. We report a 78-year-old female patient who had bipolar type 1 disorder since adolescence. Her symptoms ranged from apathy to psychotic mania. She had had three hospitalizations, and since her last stay 10 years ago, her symptoms had remained stable. However, in the past 2 years, she displayed different symptoms, such as irritability manifested as verbal and physical aggression, cognitive impairment, repetitive pattern of behavior, perambulation, persecutory delusions, disorientation, and hyporexia. Treatment with anticholinesterases or mood stabilizers promoted no improvement. She scored 17/30 points on the Mini-Mental State Examination. Neuropsychological assessment suggested deficits in executive function, attention, and memory. Neuroimaging tests revealed frontotemporal degeneration and hypoperfusion. Diagnostic and therapeutic approaches for this type of patient represent a significant challenge for clinicians.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2019-12-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000400475Dementia & Neuropsychologia v.13 n.4 2019reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/1980-57642018dn13-040016info:eu-repo/semantics/openAccessBorges,Saulo QueirozCorrêa,Thiago XavierTrindade,Isabela Oliveira AzevedoAmorim,Rivadávio Fernandes BatistaToledo,Maria Alice de Vilhenaeng2020-03-11T00:00:00Zoai:scielo:S1980-57642019000400475Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2020-03-11T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false |
dc.title.none.fl_str_mv |
Cognitive impairment in bipolar disorder Neuroprogression or behavioral variant frontotemporal dementia? |
title |
Cognitive impairment in bipolar disorder Neuroprogression or behavioral variant frontotemporal dementia? |
spellingShingle |
Cognitive impairment in bipolar disorder Neuroprogression or behavioral variant frontotemporal dementia? Borges,Saulo Queiroz bipolar disorder frontotemporal dementia geriatric neuropsychiatry neuroprogression |
title_short |
Cognitive impairment in bipolar disorder Neuroprogression or behavioral variant frontotemporal dementia? |
title_full |
Cognitive impairment in bipolar disorder Neuroprogression or behavioral variant frontotemporal dementia? |
title_fullStr |
Cognitive impairment in bipolar disorder Neuroprogression or behavioral variant frontotemporal dementia? |
title_full_unstemmed |
Cognitive impairment in bipolar disorder Neuroprogression or behavioral variant frontotemporal dementia? |
title_sort |
Cognitive impairment in bipolar disorder Neuroprogression or behavioral variant frontotemporal dementia? |
author |
Borges,Saulo Queiroz |
author_facet |
Borges,Saulo Queiroz Corrêa,Thiago Xavier Trindade,Isabela Oliveira Azevedo Amorim,Rivadávio Fernandes Batista Toledo,Maria Alice de Vilhena |
author_role |
author |
author2 |
Corrêa,Thiago Xavier Trindade,Isabela Oliveira Azevedo Amorim,Rivadávio Fernandes Batista Toledo,Maria Alice de Vilhena |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Borges,Saulo Queiroz Corrêa,Thiago Xavier Trindade,Isabela Oliveira Azevedo Amorim,Rivadávio Fernandes Batista Toledo,Maria Alice de Vilhena |
dc.subject.por.fl_str_mv |
bipolar disorder frontotemporal dementia geriatric neuropsychiatry neuroprogression |
topic |
bipolar disorder frontotemporal dementia geriatric neuropsychiatry neuroprogression |
description |
ABSTRACT Patients with Bipolar Disorder (BD) usually display cognitive deficits with aging. However, the correlation between BD and dementia syndromes is inconclusive, despite the similarity with behavioral variant frontotemporal dementia. We report a 78-year-old female patient who had bipolar type 1 disorder since adolescence. Her symptoms ranged from apathy to psychotic mania. She had had three hospitalizations, and since her last stay 10 years ago, her symptoms had remained stable. However, in the past 2 years, she displayed different symptoms, such as irritability manifested as verbal and physical aggression, cognitive impairment, repetitive pattern of behavior, perambulation, persecutory delusions, disorientation, and hyporexia. Treatment with anticholinesterases or mood stabilizers promoted no improvement. She scored 17/30 points on the Mini-Mental State Examination. Neuropsychological assessment suggested deficits in executive function, attention, and memory. Neuroimaging tests revealed frontotemporal degeneration and hypoperfusion. Diagnostic and therapeutic approaches for this type of patient represent a significant challenge for clinicians. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000400475 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000400475 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1980-57642018dn13-040016 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
dc.source.none.fl_str_mv |
Dementia & Neuropsychologia v.13 n.4 2019 reponame:Dementia & Neuropsychologia instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC) instacron:ANCC |
instname_str |
Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
instacron_str |
ANCC |
institution |
ANCC |
reponame_str |
Dementia & Neuropsychologia |
collection |
Dementia & Neuropsychologia |
repository.name.fl_str_mv |
Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
repository.mail.fl_str_mv |
||demneuropsy@uol.com.br |
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1754212932284055552 |