Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease

Detalhes bibliográficos
Autor(a) principal: Lee,Hae Won
Data de Publicação: 2007
Outros Autores: Caramelli,Paulo, Otaduy,Maria Concepcion Garcia, Nitrini,Ricardo, Leite,Claudia da Costa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642007000300248
Resumo: Abstract To compare metabolite ratios in the posterior cingulate with the Mini-Mental State Examination (MMSE) test scores in patients with mild or moderate Alzheimer disease and in controls. Methods: We evaluated 29 patients with mild or moderate Alzheimer disease and 15 controls by proton spectroscopy with the voxel located in the posterior cingulate. The MMSE was applied to all patients and controls. The metabolic ratios: N-acetyl-aspartate/creatine (Naa/Cr), mio-inositol/creatine (mI/Cr) and mio-inositol/N-acetyl-aspartate (mI/Naa) were obtained and then post-processed using the MRUI software (magnetic resonance user interface). Results: Correlation between Naa/Cr and mI/Naa ratios in the posterior cingulate with the MMSE was observed, and a positive correlation with Naa/Cr and negative correlation with mI/Naa were seen. The mI/r ratio presented no correlation with MMSE scores. Conclusion: The positive correlation with Naa/Cr, and negative correlation with mI/Naa may corroborate that neuronal density/viability is associated to a higher MMSE score.
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spelling Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer diseaseproton spectroscopyposterior cingulatesingle voxelMMSE testAlzheimer disease.Abstract To compare metabolite ratios in the posterior cingulate with the Mini-Mental State Examination (MMSE) test scores in patients with mild or moderate Alzheimer disease and in controls. Methods: We evaluated 29 patients with mild or moderate Alzheimer disease and 15 controls by proton spectroscopy with the voxel located in the posterior cingulate. The MMSE was applied to all patients and controls. The metabolic ratios: N-acetyl-aspartate/creatine (Naa/Cr), mio-inositol/creatine (mI/Cr) and mio-inositol/N-acetyl-aspartate (mI/Naa) were obtained and then post-processed using the MRUI software (magnetic resonance user interface). Results: Correlation between Naa/Cr and mI/Naa ratios in the posterior cingulate with the MMSE was observed, and a positive correlation with Naa/Cr and negative correlation with mI/Naa were seen. The mI/r ratio presented no correlation with MMSE scores. Conclusion: The positive correlation with Naa/Cr, and negative correlation with mI/Naa may corroborate that neuronal density/viability is associated to a higher MMSE score.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2007-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642007000300248Dementia & Neuropsychologia v.1 n.3 2007reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642008DN10300005info:eu-repo/semantics/openAccessLee,Hae WonCaramelli,PauloOtaduy,Maria Concepcion GarciaNitrini,RicardoLeite,Claudia da Costaeng2016-09-30T00:00:00Zoai:scielo:S1980-57642007000300248Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-09-30T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease
title Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease
spellingShingle Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease
Lee,Hae Won
proton spectroscopy
posterior cingulate
single voxel
MMSE test
Alzheimer disease.
title_short Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease
title_full Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease
title_fullStr Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease
title_full_unstemmed Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease
title_sort Mini-Mental State Examination and proton spectroscopy of the posterior cingulate in Alzheimer disease
author Lee,Hae Won
author_facet Lee,Hae Won
Caramelli,Paulo
Otaduy,Maria Concepcion Garcia
Nitrini,Ricardo
Leite,Claudia da Costa
author_role author
author2 Caramelli,Paulo
Otaduy,Maria Concepcion Garcia
Nitrini,Ricardo
Leite,Claudia da Costa
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lee,Hae Won
Caramelli,Paulo
Otaduy,Maria Concepcion Garcia
Nitrini,Ricardo
Leite,Claudia da Costa
dc.subject.por.fl_str_mv proton spectroscopy
posterior cingulate
single voxel
MMSE test
Alzheimer disease.
topic proton spectroscopy
posterior cingulate
single voxel
MMSE test
Alzheimer disease.
description Abstract To compare metabolite ratios in the posterior cingulate with the Mini-Mental State Examination (MMSE) test scores in patients with mild or moderate Alzheimer disease and in controls. Methods: We evaluated 29 patients with mild or moderate Alzheimer disease and 15 controls by proton spectroscopy with the voxel located in the posterior cingulate. The MMSE was applied to all patients and controls. The metabolic ratios: N-acetyl-aspartate/creatine (Naa/Cr), mio-inositol/creatine (mI/Cr) and mio-inositol/N-acetyl-aspartate (mI/Naa) were obtained and then post-processed using the MRUI software (magnetic resonance user interface). Results: Correlation between Naa/Cr and mI/Naa ratios in the posterior cingulate with the MMSE was observed, and a positive correlation with Naa/Cr and negative correlation with mI/Naa were seen. The mI/r ratio presented no correlation with MMSE scores. Conclusion: The positive correlation with Naa/Cr, and negative correlation with mI/Naa may corroborate that neuronal density/viability is associated to a higher MMSE score.
publishDate 2007
dc.date.none.fl_str_mv 2007-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642007000300248
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642007000300248
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1980-57642008DN10300005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.1 n.3 2007
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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