Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficits
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Radiologia Brasileira (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842020000600359 |
Resumo: | Abstract Objective: We aimed to evaluate whether human immunodeficiency virus (HIV)-positive patients with and without clinically significant memory deficits and healthy control participants differ on in vivo hydrogen-1 magnetic resonance spectroscopy (H-MRS) in the posterior cingulate gyri. Materials and Methods: In total, 21 HIV-positive patients with memory deficit (HIV+wMD) were compared with 15 HIV-positive patients without memory deficit (HIV+wOMD) and 22 sex-, age-, and education-matched control participants. Memory impairments were classified based on the participants’ performance on the Rey Auditory Verbal Learning Test. Short echo time (30 ms), single-voxel H-MRS was performed using a 1.5-T magnetic resonance scanner. Results: The HIV+wMD and HIV+wOMD groups had higher choline/creatine ratio in the posterior cingulate gyri than the control group. There were no significant metabolite ratio differences between the HIV+wMD and HIV+wOMD groups. Conclusion: HIV-positive patients with and without memory deficits had significantly higher choline/creatine ratios than controls in the posterior cingulate gyri, which may reflect cerebral inflammation, altered cell membrane metabolism, microgliosis, and/or astrocytosis. |
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Radiologia Brasileira (Online) |
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Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficitsHIVMemory deficitPosterior cingulate gyrusMagnetic resonance spectroscopyAbstract Objective: We aimed to evaluate whether human immunodeficiency virus (HIV)-positive patients with and without clinically significant memory deficits and healthy control participants differ on in vivo hydrogen-1 magnetic resonance spectroscopy (H-MRS) in the posterior cingulate gyri. Materials and Methods: In total, 21 HIV-positive patients with memory deficit (HIV+wMD) were compared with 15 HIV-positive patients without memory deficit (HIV+wOMD) and 22 sex-, age-, and education-matched control participants. Memory impairments were classified based on the participants’ performance on the Rey Auditory Verbal Learning Test. Short echo time (30 ms), single-voxel H-MRS was performed using a 1.5-T magnetic resonance scanner. Results: The HIV+wMD and HIV+wOMD groups had higher choline/creatine ratio in the posterior cingulate gyri than the control group. There were no significant metabolite ratio differences between the HIV+wMD and HIV+wOMD groups. Conclusion: HIV-positive patients with and without memory deficits had significantly higher choline/creatine ratios than controls in the posterior cingulate gyri, which may reflect cerebral inflammation, altered cell membrane metabolism, microgliosis, and/or astrocytosis.Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem2020-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842020000600359Radiologia Brasileira v.53 n.6 2020reponame:Radiologia Brasileira (Online)instname:Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR)instacron:CBR10.1590/0100-3984.2019.0093info:eu-repo/semantics/openAccessCorrêa,Diogo G.Duinkerken,Eelco vanZimmermann,NicolleFonseca,Rochele P.Gasparetto,Emerson L.eng2020-11-18T00:00:00Zoai:scielo:S0100-39842020000600359Revistahttps://www.scielo.br/j/rb/https://old.scielo.br/oai/scielo-oai.phpradiologiabrasileira@cbr.org.br1678-70990100-3984opendoar:2020-11-18T00:00Radiologia Brasileira (Online) - Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR)false |
dc.title.none.fl_str_mv |
Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficits |
title |
Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficits |
spellingShingle |
Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficits Corrêa,Diogo G. HIV Memory deficit Posterior cingulate gyrus Magnetic resonance spectroscopy |
title_short |
Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficits |
title_full |
Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficits |
title_fullStr |
Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficits |
title_full_unstemmed |
Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficits |
title_sort |
Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficits |
author |
Corrêa,Diogo G. |
author_facet |
Corrêa,Diogo G. Duinkerken,Eelco van Zimmermann,Nicolle Fonseca,Rochele P. Gasparetto,Emerson L. |
author_role |
author |
author2 |
Duinkerken,Eelco van Zimmermann,Nicolle Fonseca,Rochele P. Gasparetto,Emerson L. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Corrêa,Diogo G. Duinkerken,Eelco van Zimmermann,Nicolle Fonseca,Rochele P. Gasparetto,Emerson L. |
dc.subject.por.fl_str_mv |
HIV Memory deficit Posterior cingulate gyrus Magnetic resonance spectroscopy |
topic |
HIV Memory deficit Posterior cingulate gyrus Magnetic resonance spectroscopy |
description |
Abstract Objective: We aimed to evaluate whether human immunodeficiency virus (HIV)-positive patients with and without clinically significant memory deficits and healthy control participants differ on in vivo hydrogen-1 magnetic resonance spectroscopy (H-MRS) in the posterior cingulate gyri. Materials and Methods: In total, 21 HIV-positive patients with memory deficit (HIV+wMD) were compared with 15 HIV-positive patients without memory deficit (HIV+wOMD) and 22 sex-, age-, and education-matched control participants. Memory impairments were classified based on the participants’ performance on the Rey Auditory Verbal Learning Test. Short echo time (30 ms), single-voxel H-MRS was performed using a 1.5-T magnetic resonance scanner. Results: The HIV+wMD and HIV+wOMD groups had higher choline/creatine ratio in the posterior cingulate gyri than the control group. There were no significant metabolite ratio differences between the HIV+wMD and HIV+wOMD groups. Conclusion: HIV-positive patients with and without memory deficits had significantly higher choline/creatine ratios than controls in the posterior cingulate gyri, which may reflect cerebral inflammation, altered cell membrane metabolism, microgliosis, and/or astrocytosis. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842020000600359 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-39842020000600359 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0100-3984.2019.0093 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
publisher.none.fl_str_mv |
Publicação do Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
dc.source.none.fl_str_mv |
Radiologia Brasileira v.53 n.6 2020 reponame:Radiologia Brasileira (Online) instname:Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR) instacron:CBR |
instname_str |
Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR) |
instacron_str |
CBR |
institution |
CBR |
reponame_str |
Radiologia Brasileira (Online) |
collection |
Radiologia Brasileira (Online) |
repository.name.fl_str_mv |
Radiologia Brasileira (Online) - Colégio Brasileiro de Radiologia e Diagnóstico por Imagem (CBR) |
repository.mail.fl_str_mv |
radiologiabrasileira@cbr.org.br |
_version_ |
1754208940682379264 |