Diagnostic approach in a patient with Creutzfeldt-Jakob disease

• Autor(a) principal: Tavares-Júnior,José Wagner Leonel
• Data de Publicação: 2022
• Outros Autores: Carvalho,Renata de Oliveira, Feitosa,Raul Raposo Pereira, Rolim,Flávia de Paiva Santos, Rocha,Felipe Araújo, Pitombeira,Milena Sales, Malveira,George Linard Silva, Carvalho,João José Freitas de, Frota,Norberto Anizio Ferreira, Dias,Daniel Aguiar
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Dementia & Neuropsychologia
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642022000300361
• topic: Prion Diseases; Creutzfeldt-Jakob Syndrome; Dementia

ABSTRACT Prion diseases are an important cause of rapidly progressive dementias. Among them, the most common is sporadic Creutzfeldt-Jakob disease (CJD). It is a rare and incurable disease, with rapid progression to death. Objective: To describe the diagnostic approach of a patient with Creutzfeldt-Jakob disease. Methods: The diagnosis is established through the clinical picture associated with characteristic changes in the brain magnetic resonance imaging, the electroencephalogram, and analysis of specific changes in the cerebrospinal fluid. Results: The present report describes the case of a 53-year-old patient in the city of Fortaleza-CE. The diagnosis was made based on the clinical condition and through diagnostic tests, including 14-3-3 protein and RT QUIC analysis. Differential diagnosis was performed with other rapidly progressive causes, such as infectious and immune-mediated diseases. Conclusions: The diagnosis of probable sporadic CJD was established.