Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition

Detalhes bibliográficos
Autor(a) principal: Oliveira-Filho,Jamary
Data de Publicação: 2009
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100022
Resumo: Abstract Chagas disease (CD) remains a major cause of cardiomyopathy and stroke in developing countries. Brain damage in CD has been attributed exclusively to the effects of structural heart disease on the brain, including cardioembolism and low cardiac output symptoms. However, CD patients also develop stroke and brain atrophy independently of cardiac disease severity. Chronic inflammation directed against T. cruzi may act as a trigger for endothelial damage, platelet activation, acceleration of atherosclerosis and apoptosis, all of which lead to stroke and brain atrophy. In the present article, evidence supporting this new theory is presented, along with considerations towards mechanistically-based targeted treatment.
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spelling Stroke and brain atrophy in chronic Chagas disease patients: A new theory propositionChagas diseaseAmerican trypanosomiasiscognitioncerebrovascular disorderspathogenesis.Abstract Chagas disease (CD) remains a major cause of cardiomyopathy and stroke in developing countries. Brain damage in CD has been attributed exclusively to the effects of structural heart disease on the brain, including cardioembolism and low cardiac output symptoms. However, CD patients also develop stroke and brain atrophy independently of cardiac disease severity. Chronic inflammation directed against T. cruzi may act as a trigger for endothelial damage, platelet activation, acceleration of atherosclerosis and apoptosis, all of which lead to stroke and brain atrophy. In the present article, evidence supporting this new theory is presented, along with considerations towards mechanistically-based targeted treatment.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2009-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100022Dementia & Neuropsychologia v.3 n.1 2009reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642009DN30100005info:eu-repo/semantics/openAccessOliveira-Filho,Jamaryeng2016-07-29T00:00:00Zoai:scielo:S1980-57642009000100022Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-07-29T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition
title Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition
spellingShingle Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition
Oliveira-Filho,Jamary
Chagas disease
American trypanosomiasis
cognition
cerebrovascular disorders
pathogenesis.
title_short Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition
title_full Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition
title_fullStr Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition
title_full_unstemmed Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition
title_sort Stroke and brain atrophy in chronic Chagas disease patients: A new theory proposition
author Oliveira-Filho,Jamary
author_facet Oliveira-Filho,Jamary
author_role author
dc.contributor.author.fl_str_mv Oliveira-Filho,Jamary
dc.subject.por.fl_str_mv Chagas disease
American trypanosomiasis
cognition
cerebrovascular disorders
pathogenesis.
topic Chagas disease
American trypanosomiasis
cognition
cerebrovascular disorders
pathogenesis.
description Abstract Chagas disease (CD) remains a major cause of cardiomyopathy and stroke in developing countries. Brain damage in CD has been attributed exclusively to the effects of structural heart disease on the brain, including cardioembolism and low cardiac output symptoms. However, CD patients also develop stroke and brain atrophy independently of cardiac disease severity. Chronic inflammation directed against T. cruzi may act as a trigger for endothelial damage, platelet activation, acceleration of atherosclerosis and apoptosis, all of which lead to stroke and brain atrophy. In the present article, evidence supporting this new theory is presented, along with considerations towards mechanistically-based targeted treatment.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100022
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000100022
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1980-57642009DN30100005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.3 n.1 2009
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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