Chagas disease is independently associated with brain atrophy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13501 |
Resumo: | Texto completo: acesso restrito. p. 1363-1365 |
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Oliveira Filho, JamaryMelo, Rodrigo Morel Vieira deReis, Paulo S. O.Lacerda, Amanda M.Neville, Iuri S.Cincura, CarolinaMenezes, Daniela F.Viana, Leila CastroJesus, Pedro A. P.Lopes, Antonio Alberto da SilvaReis, Francisco J. F. B.Furie, Karen L.Oliveira Filho, JamaryMelo, Rodrigo Morel Vieira deReis, Paulo S. O.Lacerda, Amanda M.Neville, Iuri S.Cincura, CarolinaMenezes, Daniela F.Viana, Leila CastroJesus, Pedro A. P.Lopes, Antonio Alberto da SilvaReis, Francisco J. F. B.Furie, Karen L.2013-11-01T19:46:48Z20090340-5354http://repositorio.ufba.br/ri/handle/ri/13501v. 256, n. 8Texto completo: acesso restrito. p. 1363-1365Chagas disease (CD) remains a major cause of cardiomyopathy and stroke in developing countries. Brain involvement in CD has been attributed to left ventricular dysfunction, resulting in chronic brain ischemia due to hypoperfusion and/or embolic infarcts. However, cognitive impairment in CD may occur independently of cardiac disease. Therefore, we aimed to investigate head computed tomography (CT) findings in patients with Chagas disease cardiomyopathy (CDC) in comparison with other cardiomyopathies (OC). We studied 73 patients with CDC (n = 41) or OC (n = 32) matched for age and gender. These patients underwent head CT, rated by an investigator blinded to all clinical information. Head CT was rated for the presence of lacunar or territorial infarcts, as well as for measuring the total volumes of the brain, cerebellum and ventricles. Total brain volume was smaller in CDC as compared to OC patients (1,135 ± 150 vs. 1,332 ± 198 cm3, P < 0.001). Cerebellar and ventricular volumes did not differ between the groups. The prevalence of brain infarcts did not differ significantly between the groups. Chagas disease was the only independent predictor of brain atrophy in the multivariable analysis (OR = 1.38; 95% CI = 1.06–1.79, P = 0.017). Chagas disease is associated with brain atrophy independent of structural cardiac disease related to cardiomyopathy. Brain atrophy, rather than multiple infarcts, may represent the main anatomical substrate of cognitive impairment in Chagas disease.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-10-02T12:36:56Z No. of bitstreams: 1 art%3A10.1007%2Fs00415-009-5105-7.pdf: 139173 bytes, checksum: 9239c90664bf232c2527c6feb4d5baef (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-01T19:46:48Z (GMT) No. of bitstreams: 1 art%3A10.1007%2Fs00415-009-5105-7.pdf: 139173 bytes, checksum: 9239c90664bf232c2527c6feb4d5baef (MD5)Made available in DSpace on 2013-11-01T19:46:48Z (GMT). No. of bitstreams: 1 art%3A10.1007%2Fs00415-009-5105-7.pdf: 139173 bytes, checksum: 9239c90664bf232c2527c6feb4d5baef (MD5) Previous issue date: 2009http://dx.doi.org/10.1007/s00415-009-5105-7reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAOther cerebrovascular disease/strokeAll cognitive disorders/dementiaComputed tomographyParasitic infectionsChagas disease is independently associated with brain atrophyJournal of Neurologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINALart%3A10.1007%2Fs00415-009-5105-7.pdfart%3A10.1007%2Fs00415-009-5105-7.pdfapplication/pdf139173https://repositorio.ufba.br/bitstream/ri/13501/1/art%253A10.1007%252Fs00415-009-5105-7.pdf9239c90664bf232c2527c6feb4d5baefMD51LICENSElicense.txtlicense.txttext/plain1365https://repositorio.ufba.br/bitstream/ri/13501/2/license.txt5371a150bdc863f78dcf39281543bd86MD52TEXTart%3A10.1007%2Fs00415-009-5105-7.pdf.txtart%3A10.1007%2Fs00415-009-5105-7.pdf.txtExtracted texttext/plain12958https://repositorio.ufba.br/bitstream/ri/13501/3/art%253A10.1007%252Fs00415-009-5105-7.pdf.txta0451c37d1dcf31c079dff1b55e701acMD53ri/135012022-07-05 14:02:51.625oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:51Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Chagas disease is independently associated with brain atrophy |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Neurology |
| title |
Chagas disease is independently associated with brain atrophy |
| spellingShingle |
Chagas disease is independently associated with brain atrophy Oliveira Filho, Jamary Other cerebrovascular disease/stroke All cognitive disorders/dementia Computed tomography Parasitic infections |
| title_short |
Chagas disease is independently associated with brain atrophy |
| title_full |
Chagas disease is independently associated with brain atrophy |
| title_fullStr |
Chagas disease is independently associated with brain atrophy |
| title_full_unstemmed |
Chagas disease is independently associated with brain atrophy |
| title_sort |
Chagas disease is independently associated with brain atrophy |
| author |
Oliveira Filho, Jamary |
| author_facet |
Oliveira Filho, Jamary Melo, Rodrigo Morel Vieira de Reis, Paulo S. O. Lacerda, Amanda M. Neville, Iuri S. Cincura, Carolina Menezes, Daniela F. Viana, Leila Castro Jesus, Pedro A. P. Lopes, Antonio Alberto da Silva Reis, Francisco J. F. B. Furie, Karen L. |
| author_role |
author |
| author2 |
Melo, Rodrigo Morel Vieira de Reis, Paulo S. O. Lacerda, Amanda M. Neville, Iuri S. Cincura, Carolina Menezes, Daniela F. Viana, Leila Castro Jesus, Pedro A. P. Lopes, Antonio Alberto da Silva Reis, Francisco J. F. B. Furie, Karen L. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira Filho, Jamary Melo, Rodrigo Morel Vieira de Reis, Paulo S. O. Lacerda, Amanda M. Neville, Iuri S. Cincura, Carolina Menezes, Daniela F. Viana, Leila Castro Jesus, Pedro A. P. Lopes, Antonio Alberto da Silva Reis, Francisco J. F. B. Furie, Karen L. Oliveira Filho, Jamary Melo, Rodrigo Morel Vieira de Reis, Paulo S. O. Lacerda, Amanda M. Neville, Iuri S. Cincura, Carolina Menezes, Daniela F. Viana, Leila Castro Jesus, Pedro A. P. Lopes, Antonio Alberto da Silva Reis, Francisco J. F. B. Furie, Karen L. |
| dc.subject.por.fl_str_mv |
Other cerebrovascular disease/stroke All cognitive disorders/dementia Computed tomography Parasitic infections |
| topic |
Other cerebrovascular disease/stroke All cognitive disorders/dementia Computed tomography Parasitic infections |
| description |
Texto completo: acesso restrito. p. 1363-1365 |
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2009 |
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2009 |
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2013-11-01T19:46:48Z |
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0340-5354 |
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v. 256, n. 8 |
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