Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study

Detalhes bibliográficos
Autor(a) principal: Takada,Leonel Tadao
Data de Publicação: 2009
Outros Autores: Camiz,Paulo, Grinberg,Lea T., Leite,Claudia da Costa
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Dementia & Neuropsychologia
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000400352
Resumo: Abstract A 77 year-old men developed a subacute-onset, rapidly progressive cognitive decline. After 6 months of evolution, he scored 6 on the Mini-Mental State Examination and had left hemiparesis and hemineglect. The patient died 11 months after the onset of cognitive symptoms. Brain MRI showed microhemorrhages on gradient-echo sequence and confluent areas of white matter hyperintensities on T2-weighted images. Brain biopsy revealed amyloid-b peptide deposition in vessel walls, some of them surrounded by micro-bleeds. In this case report, we discuss the role of cerebral amyloid angiopathy (CAA) in cognitive decline, due to structural lesions associated with hemorrhages and infarcts, white matter lesions and co-morbidity of Alzheimer's disease, as well as the most recently described amyloid angiopathy-related inflammation.
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spelling Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case studydementiacerebral amyloid angiopathyvascular dementia.Abstract A 77 year-old men developed a subacute-onset, rapidly progressive cognitive decline. After 6 months of evolution, he scored 6 on the Mini-Mental State Examination and had left hemiparesis and hemineglect. The patient died 11 months after the onset of cognitive symptoms. Brain MRI showed microhemorrhages on gradient-echo sequence and confluent areas of white matter hyperintensities on T2-weighted images. Brain biopsy revealed amyloid-b peptide deposition in vessel walls, some of them surrounded by micro-bleeds. In this case report, we discuss the role of cerebral amyloid angiopathy (CAA) in cognitive decline, due to structural lesions associated with hemorrhages and infarcts, white matter lesions and co-morbidity of Alzheimer's disease, as well as the most recently described amyloid angiopathy-related inflammation.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2009-12-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000400352Dementia & Neuropsychologia v.3 n.4 2009reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642009DN30400015info:eu-repo/semantics/openAccessTakada,Leonel TadaoCamiz,PauloGrinberg,Lea T.Leite,Claudia da Costaeng2016-07-28T00:00:00Zoai:scielo:S1980-57642009000400352Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-07-28T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false
dc.title.none.fl_str_mv Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study
title Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study
spellingShingle Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study
Takada,Leonel Tadao
dementia
cerebral amyloid angiopathy
vascular dementia.
title_short Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study
title_full Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study
title_fullStr Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study
title_full_unstemmed Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study
title_sort Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study
author Takada,Leonel Tadao
author_facet Takada,Leonel Tadao
Camiz,Paulo
Grinberg,Lea T.
Leite,Claudia da Costa
author_role author
author2 Camiz,Paulo
Grinberg,Lea T.
Leite,Claudia da Costa
author2_role author
author
author
dc.contributor.author.fl_str_mv Takada,Leonel Tadao
Camiz,Paulo
Grinberg,Lea T.
Leite,Claudia da Costa
dc.subject.por.fl_str_mv dementia
cerebral amyloid angiopathy
vascular dementia.
topic dementia
cerebral amyloid angiopathy
vascular dementia.
description Abstract A 77 year-old men developed a subacute-onset, rapidly progressive cognitive decline. After 6 months of evolution, he scored 6 on the Mini-Mental State Examination and had left hemiparesis and hemineglect. The patient died 11 months after the onset of cognitive symptoms. Brain MRI showed microhemorrhages on gradient-echo sequence and confluent areas of white matter hyperintensities on T2-weighted images. Brain biopsy revealed amyloid-b peptide deposition in vessel walls, some of them surrounded by micro-bleeds. In this case report, we discuss the role of cerebral amyloid angiopathy (CAA) in cognitive decline, due to structural lesions associated with hemorrhages and infarcts, white matter lesions and co-morbidity of Alzheimer's disease, as well as the most recently described amyloid angiopathy-related inflammation.
publishDate 2009
dc.date.none.fl_str_mv 2009-12-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format report
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000400352
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000400352
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1980-57642009DN30400015
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
publisher.none.fl_str_mv Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento
dc.source.none.fl_str_mv Dementia & Neuropsychologia v.3 n.4 2009
reponame:Dementia & Neuropsychologia
instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron:ANCC
instname_str Associação de Neurologia Cognitiva e do Comportamento (ANCC)
instacron_str ANCC
institution ANCC
reponame_str Dementia & Neuropsychologia
collection Dementia & Neuropsychologia
repository.name.fl_str_mv Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)
repository.mail.fl_str_mv ||demneuropsy@uol.com.br
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