Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Relatório |
Idioma: | eng |
Título da fonte: | Dementia & Neuropsychologia |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000400352 |
Resumo: | Abstract A 77 year-old men developed a subacute-onset, rapidly progressive cognitive decline. After 6 months of evolution, he scored 6 on the Mini-Mental State Examination and had left hemiparesis and hemineglect. The patient died 11 months after the onset of cognitive symptoms. Brain MRI showed microhemorrhages on gradient-echo sequence and confluent areas of white matter hyperintensities on T2-weighted images. Brain biopsy revealed amyloid-b peptide deposition in vessel walls, some of them surrounded by micro-bleeds. In this case report, we discuss the role of cerebral amyloid angiopathy (CAA) in cognitive decline, due to structural lesions associated with hemorrhages and infarcts, white matter lesions and co-morbidity of Alzheimer's disease, as well as the most recently described amyloid angiopathy-related inflammation. |
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Dementia & Neuropsychologia |
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Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case studydementiacerebral amyloid angiopathyvascular dementia.Abstract A 77 year-old men developed a subacute-onset, rapidly progressive cognitive decline. After 6 months of evolution, he scored 6 on the Mini-Mental State Examination and had left hemiparesis and hemineglect. The patient died 11 months after the onset of cognitive symptoms. Brain MRI showed microhemorrhages on gradient-echo sequence and confluent areas of white matter hyperintensities on T2-weighted images. Brain biopsy revealed amyloid-b peptide deposition in vessel walls, some of them surrounded by micro-bleeds. In this case report, we discuss the role of cerebral amyloid angiopathy (CAA) in cognitive decline, due to structural lesions associated with hemorrhages and infarcts, white matter lesions and co-morbidity of Alzheimer's disease, as well as the most recently described amyloid angiopathy-related inflammation.Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento2009-12-01info:eu-repo/semantics/reportinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000400352Dementia & Neuropsychologia v.3 n.4 2009reponame:Dementia & Neuropsychologiainstname:Associação de Neurologia Cognitiva e do Comportamento (ANCC)instacron:ANCC10.1590/S1980-57642009DN30400015info:eu-repo/semantics/openAccessTakada,Leonel TadaoCamiz,PauloGrinberg,Lea T.Leite,Claudia da Costaeng2016-07-28T00:00:00Zoai:scielo:S1980-57642009000400352Revistahttp://www.demneuropsy.com.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||demneuropsy@uol.com.br1980-57641980-5764opendoar:2016-07-28T00:00Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC)false |
dc.title.none.fl_str_mv |
Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
title |
Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
spellingShingle |
Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study Takada,Leonel Tadao dementia cerebral amyloid angiopathy vascular dementia. |
title_short |
Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
title_full |
Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
title_fullStr |
Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
title_full_unstemmed |
Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
title_sort |
Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
author |
Takada,Leonel Tadao |
author_facet |
Takada,Leonel Tadao Camiz,Paulo Grinberg,Lea T. Leite,Claudia da Costa |
author_role |
author |
author2 |
Camiz,Paulo Grinberg,Lea T. Leite,Claudia da Costa |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Takada,Leonel Tadao Camiz,Paulo Grinberg,Lea T. Leite,Claudia da Costa |
dc.subject.por.fl_str_mv |
dementia cerebral amyloid angiopathy vascular dementia. |
topic |
dementia cerebral amyloid angiopathy vascular dementia. |
description |
Abstract A 77 year-old men developed a subacute-onset, rapidly progressive cognitive decline. After 6 months of evolution, he scored 6 on the Mini-Mental State Examination and had left hemiparesis and hemineglect. The patient died 11 months after the onset of cognitive symptoms. Brain MRI showed microhemorrhages on gradient-echo sequence and confluent areas of white matter hyperintensities on T2-weighted images. Brain biopsy revealed amyloid-b peptide deposition in vessel walls, some of them surrounded by micro-bleeds. In this case report, we discuss the role of cerebral amyloid angiopathy (CAA) in cognitive decline, due to structural lesions associated with hemorrhages and infarcts, white matter lesions and co-morbidity of Alzheimer's disease, as well as the most recently described amyloid angiopathy-related inflammation. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/report |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
report |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000400352 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000400352 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1980-57642009DN30400015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
publisher.none.fl_str_mv |
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento |
dc.source.none.fl_str_mv |
Dementia & Neuropsychologia v.3 n.4 2009 reponame:Dementia & Neuropsychologia instname:Associação de Neurologia Cognitiva e do Comportamento (ANCC) instacron:ANCC |
instname_str |
Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
instacron_str |
ANCC |
institution |
ANCC |
reponame_str |
Dementia & Neuropsychologia |
collection |
Dementia & Neuropsychologia |
repository.name.fl_str_mv |
Dementia & Neuropsychologia - Associação de Neurologia Cognitiva e do Comportamento (ANCC) |
repository.mail.fl_str_mv |
||demneuropsy@uol.com.br |
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1754212929680441344 |