Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022000300390 |
Resumo: | ABSTRACT BACKGROUND: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction. OBJECTIVE: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). DESIGN AND SETTING: Prospective study at a university hospital in Turkey. METHODS: The study group consisted of 50 mothers with GDM, and 59 healthy mothers served as controls. Umbilical cord blood samples were taken from all mothers during delivery and breast milk samples on the fifth day after delivery. TAC, TOS, thiol and disulfide levels were measured. RESULTS: No statistically significant relationship between the blood and milk samples could be found. An analysis on correlations between TAC, TOS and certain parameters revealed that there were negative correlations between TOS and total thiol (r = -0.386; P < 0.001) and between TOS and disulfide (r = -0.388; P < 0.001) in milk in the control group. However, these findings were not observed in the study group. CONCLUSION: Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation. |
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Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective studyDiabetes mellitus, gestationalStress, oxidativeAntioxidantsGestational diabetes mellitusOxidative stress indexTotal antioxidant capacityTotal oxidant statusABSTRACT BACKGROUND: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction. OBJECTIVE: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). DESIGN AND SETTING: Prospective study at a university hospital in Turkey. METHODS: The study group consisted of 50 mothers with GDM, and 59 healthy mothers served as controls. Umbilical cord blood samples were taken from all mothers during delivery and breast milk samples on the fifth day after delivery. TAC, TOS, thiol and disulfide levels were measured. RESULTS: No statistically significant relationship between the blood and milk samples could be found. An analysis on correlations between TAC, TOS and certain parameters revealed that there were negative correlations between TOS and total thiol (r = -0.386; P < 0.001) and between TOS and disulfide (r = -0.388; P < 0.001) in milk in the control group. However, these findings were not observed in the study group. CONCLUSION: Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation.Associação Paulista de Medicina - APM2022-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022000300390Sao Paulo Medical Journal v.140 n.3 2022reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/1516-3180.2021.0209.r1.25082021info:eu-repo/semantics/openAccessErdoğan,FıratŞenkal,EvrimÖzer,Ömer Farukİpek,İlke ÖzahiAltuntaş,Şükriye LeylaÖzde,Şükriyeeng2022-05-12T00:00:00Zoai:scielo:S1516-31802022000300390Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2022-05-12T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
title |
Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
spellingShingle |
Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study Erdoğan,Fırat Diabetes mellitus, gestational Stress, oxidative Antioxidants Gestational diabetes mellitus Oxidative stress index Total antioxidant capacity Total oxidant status |
title_short |
Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
title_full |
Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
title_fullStr |
Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
title_full_unstemmed |
Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
title_sort |
Oxidative stress in maternal milk and cord blood in gestational diabetes mellitus: a prospective study |
author |
Erdoğan,Fırat |
author_facet |
Erdoğan,Fırat Şenkal,Evrim Özer,Ömer Faruk İpek,İlke Özahi Altuntaş,Şükriye Leyla Özde,Şükriye |
author_role |
author |
author2 |
Şenkal,Evrim Özer,Ömer Faruk İpek,İlke Özahi Altuntaş,Şükriye Leyla Özde,Şükriye |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Erdoğan,Fırat Şenkal,Evrim Özer,Ömer Faruk İpek,İlke Özahi Altuntaş,Şükriye Leyla Özde,Şükriye |
dc.subject.por.fl_str_mv |
Diabetes mellitus, gestational Stress, oxidative Antioxidants Gestational diabetes mellitus Oxidative stress index Total antioxidant capacity Total oxidant status |
topic |
Diabetes mellitus, gestational Stress, oxidative Antioxidants Gestational diabetes mellitus Oxidative stress index Total antioxidant capacity Total oxidant status |
description |
ABSTRACT BACKGROUND: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction. OBJECTIVE: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). DESIGN AND SETTING: Prospective study at a university hospital in Turkey. METHODS: The study group consisted of 50 mothers with GDM, and 59 healthy mothers served as controls. Umbilical cord blood samples were taken from all mothers during delivery and breast milk samples on the fifth day after delivery. TAC, TOS, thiol and disulfide levels were measured. RESULTS: No statistically significant relationship between the blood and milk samples could be found. An analysis on correlations between TAC, TOS and certain parameters revealed that there were negative correlations between TOS and total thiol (r = -0.386; P < 0.001) and between TOS and disulfide (r = -0.388; P < 0.001) in milk in the control group. However, these findings were not observed in the study group. CONCLUSION: Our findings suggested that a compensatory mechanism of oxidative stress was expected to be present in gestational diabetes mellitus and that this might be ameliorated through good glycemic regulation and antioxidant supplementation. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022000300390 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802022000300390 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/1516-3180.2021.0209.r1.25082021 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.140 n.3 2022 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209268667514880 |