Possible mechanisms of chronic leprosy-related arthritis

Detalhes bibliográficos
Autor(a) principal: Cossermelli-Messina,Waldenise
Data de Publicação: 1997
Outros Autores: Cossermelli,Wilson
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000200007
Resumo: Microbial agents induce arthritis through mechanisms such as direct infiltration of tissue and by inducing autoimmune phenomena. The mechanisms involved in this last type of arthritis have been investigated. In experimental models of adjuvant and reactive arthritis, the involvement of T cells and in some cases mycobacteria in the development of arthritis have been confirmed. Cross-reactivity between the 65 kD mycobacterial protein and cartilage proteoglycans has been postulated as a possible mechanism. In this study, chronic peripheral arthritis was observed in patients with Hansen's disease, in patients with resolved Hansen's and in those with paucibacillary forms. This arthritis was not related to reactional states (erythema nodosum Ieprosum and reversal reaction), in contrast to several reports in the literature. The mechanisms by which microbes could induce chronic arthritis are discussed herein.
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spelling Possible mechanisms of chronic leprosy-related arthritisMycobacteriacellular immunityhumoral immunityleprosy arthritisMicrobial agents induce arthritis through mechanisms such as direct infiltration of tissue and by inducing autoimmune phenomena. The mechanisms involved in this last type of arthritis have been investigated. In experimental models of adjuvant and reactive arthritis, the involvement of T cells and in some cases mycobacteria in the development of arthritis have been confirmed. Cross-reactivity between the 65 kD mycobacterial protein and cartilage proteoglycans has been postulated as a possible mechanism. In this study, chronic peripheral arthritis was observed in patients with Hansen's disease, in patients with resolved Hansen's and in those with paucibacillary forms. This arthritis was not related to reactional states (erythema nodosum Ieprosum and reversal reaction), in contrast to several reports in the literature. The mechanisms by which microbes could induce chronic arthritis are discussed herein.Associação Paulista de Medicina - APM1997-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000200007Sao Paulo Medical Journal v.115 n.2 1997reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31801997000200007info:eu-repo/semantics/openAccessCossermelli-Messina,WaldeniseCossermelli,Wilsoneng2008-11-06T00:00:00Zoai:scielo:S1516-31801997000200007Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2008-11-06T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Possible mechanisms of chronic leprosy-related arthritis
title Possible mechanisms of chronic leprosy-related arthritis
spellingShingle Possible mechanisms of chronic leprosy-related arthritis
Cossermelli-Messina,Waldenise
Mycobacteria
cellular immunity
humoral immunity
leprosy arthritis
title_short Possible mechanisms of chronic leprosy-related arthritis
title_full Possible mechanisms of chronic leprosy-related arthritis
title_fullStr Possible mechanisms of chronic leprosy-related arthritis
title_full_unstemmed Possible mechanisms of chronic leprosy-related arthritis
title_sort Possible mechanisms of chronic leprosy-related arthritis
author Cossermelli-Messina,Waldenise
author_facet Cossermelli-Messina,Waldenise
Cossermelli,Wilson
author_role author
author2 Cossermelli,Wilson
author2_role author
dc.contributor.author.fl_str_mv Cossermelli-Messina,Waldenise
Cossermelli,Wilson
dc.subject.por.fl_str_mv Mycobacteria
cellular immunity
humoral immunity
leprosy arthritis
topic Mycobacteria
cellular immunity
humoral immunity
leprosy arthritis
description Microbial agents induce arthritis through mechanisms such as direct infiltration of tissue and by inducing autoimmune phenomena. The mechanisms involved in this last type of arthritis have been investigated. In experimental models of adjuvant and reactive arthritis, the involvement of T cells and in some cases mycobacteria in the development of arthritis have been confirmed. Cross-reactivity between the 65 kD mycobacterial protein and cartilage proteoglycans has been postulated as a possible mechanism. In this study, chronic peripheral arthritis was observed in patients with Hansen's disease, in patients with resolved Hansen's and in those with paucibacillary forms. This arthritis was not related to reactional states (erythema nodosum Ieprosum and reversal reaction), in contrast to several reports in the literature. The mechanisms by which microbes could induce chronic arthritis are discussed herein.
publishDate 1997
dc.date.none.fl_str_mv 1997-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000200007
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31801997000200007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-31801997000200007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.115 n.2 1997
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
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