Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects
Autor(a) principal: | |
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Data de Publicação: | 2001 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | São Paulo medical journal (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000300006 |
Resumo: | CONTEXT: Protein marker positivity can assist in the definition of the therapeutic approach towards head and neck paragangliomas. The establishment of the therapeutic approach should incorporate the results of such an investigation. OBJECTIVE: To establish criteria for benignancy and malignancy of vagal and jugular-tympanic paragangliomas, via the study of the relationships of sex, age, tumor size, duration of complaints, site, family history, presence of metastases, treatment, histological architecture and cell type with the immunohistochemical reactions to S100 protein, chromogranin and AgKi67. DESIGN: A retrospective study of histological and clinical records. SETTING: The Heliópolis and Oswaldo Cruz tertiary general hospitals, São Paulo. SAMPLE: 8 cases of head and neck paragangliomas. MAIN MEASUREMENTS: Determination of degree of positivity to paragangliomas via immunohistochemical reactions. RESULTS: 1). The protein markers for the principal cells (AgKi67 and chromogranin) were sensitive in 100% of the tumors when used together. 2). S100 protein was well identified in the cytoplasm and nucleus of sustentacular cells and underwent reduction in the neoplasias. CONCLUSIONS: Chromogranin was proven to be a generic marker for neuroendocrine tumors; S100 protein was positive in all 8 cases and the AgKi67 had low positivity in all cases. |
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Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspectsParagangliomasMarkersAgKi67ChromograninS100 proteinCONTEXT: Protein marker positivity can assist in the definition of the therapeutic approach towards head and neck paragangliomas. The establishment of the therapeutic approach should incorporate the results of such an investigation. OBJECTIVE: To establish criteria for benignancy and malignancy of vagal and jugular-tympanic paragangliomas, via the study of the relationships of sex, age, tumor size, duration of complaints, site, family history, presence of metastases, treatment, histological architecture and cell type with the immunohistochemical reactions to S100 protein, chromogranin and AgKi67. DESIGN: A retrospective study of histological and clinical records. SETTING: The Heliópolis and Oswaldo Cruz tertiary general hospitals, São Paulo. SAMPLE: 8 cases of head and neck paragangliomas. MAIN MEASUREMENTS: Determination of degree of positivity to paragangliomas via immunohistochemical reactions. RESULTS: 1). The protein markers for the principal cells (AgKi67 and chromogranin) were sensitive in 100% of the tumors when used together. 2). S100 protein was well identified in the cytoplasm and nucleus of sustentacular cells and underwent reduction in the neoplasias. CONCLUSIONS: Chromogranin was proven to be a generic marker for neuroendocrine tumors; S100 protein was positive in all 8 cases and the AgKi67 had low positivity in all cases.Associação Paulista de Medicina - APM2001-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000300006Sao Paulo Medical Journal v.119 n.3 2001reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31802001000300006info:eu-repo/semantics/openAccessAndrade Filho,Pedro de Alcântara deRapoport,AbrãoAlves,Venâncio Avancini FerreiraDenardin,Odilon Victor PortoAndrade Sobrinho,Josias deCarvalho,Marcos Brasilino deeng2001-05-30T00:00:00Zoai:scielo:S1516-31802001000300006Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2001-05-30T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse |
dc.title.none.fl_str_mv |
Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects |
title |
Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects |
spellingShingle |
Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects Andrade Filho,Pedro de Alcântara de Paragangliomas Markers AgKi67 Chromogranin S100 protein |
title_short |
Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects |
title_full |
Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects |
title_fullStr |
Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects |
title_full_unstemmed |
Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects |
title_sort |
Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects |
author |
Andrade Filho,Pedro de Alcântara de |
author_facet |
Andrade Filho,Pedro de Alcântara de Rapoport,Abrão Alves,Venâncio Avancini Ferreira Denardin,Odilon Victor Porto Andrade Sobrinho,Josias de Carvalho,Marcos Brasilino de |
author_role |
author |
author2 |
Rapoport,Abrão Alves,Venâncio Avancini Ferreira Denardin,Odilon Victor Porto Andrade Sobrinho,Josias de Carvalho,Marcos Brasilino de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Andrade Filho,Pedro de Alcântara de Rapoport,Abrão Alves,Venâncio Avancini Ferreira Denardin,Odilon Victor Porto Andrade Sobrinho,Josias de Carvalho,Marcos Brasilino de |
dc.subject.por.fl_str_mv |
Paragangliomas Markers AgKi67 Chromogranin S100 protein |
topic |
Paragangliomas Markers AgKi67 Chromogranin S100 protein |
description |
CONTEXT: Protein marker positivity can assist in the definition of the therapeutic approach towards head and neck paragangliomas. The establishment of the therapeutic approach should incorporate the results of such an investigation. OBJECTIVE: To establish criteria for benignancy and malignancy of vagal and jugular-tympanic paragangliomas, via the study of the relationships of sex, age, tumor size, duration of complaints, site, family history, presence of metastases, treatment, histological architecture and cell type with the immunohistochemical reactions to S100 protein, chromogranin and AgKi67. DESIGN: A retrospective study of histological and clinical records. SETTING: The Heliópolis and Oswaldo Cruz tertiary general hospitals, São Paulo. SAMPLE: 8 cases of head and neck paragangliomas. MAIN MEASUREMENTS: Determination of degree of positivity to paragangliomas via immunohistochemical reactions. RESULTS: 1). The protein markers for the principal cells (AgKi67 and chromogranin) were sensitive in 100% of the tumors when used together. 2). S100 protein was well identified in the cytoplasm and nucleus of sustentacular cells and underwent reduction in the neoplasias. CONCLUSIONS: Chromogranin was proven to be a generic marker for neuroendocrine tumors; S100 protein was positive in all 8 cases and the AgKi67 had low positivity in all cases. |
publishDate |
2001 |
dc.date.none.fl_str_mv |
2001-05-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000300006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000300006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1516-31802001000300006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
publisher.none.fl_str_mv |
Associação Paulista de Medicina - APM |
dc.source.none.fl_str_mv |
Sao Paulo Medical Journal v.119 n.3 2001 reponame:São Paulo medical journal (Online) instname:Associação Paulista de Medicina instacron:APM |
instname_str |
Associação Paulista de Medicina |
instacron_str |
APM |
institution |
APM |
reponame_str |
São Paulo medical journal (Online) |
collection |
São Paulo medical journal (Online) |
repository.name.fl_str_mv |
São Paulo medical journal (Online) - Associação Paulista de Medicina |
repository.mail.fl_str_mv |
revistas@apm.org.br |
_version_ |
1754209260376424448 |