Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects

Detalhes bibliográficos
Autor(a) principal: Andrade Filho,Pedro de Alcântara de
Data de Publicação: 2001
Outros Autores: Rapoport,Abrão, Alves,Venâncio Avancini Ferreira, Denardin,Odilon Victor Porto, Andrade Sobrinho,Josias de, Carvalho,Marcos Brasilino de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: São Paulo medical journal (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000300006
Resumo: CONTEXT: Protein marker positivity can assist in the definition of the therapeutic approach towards head and neck paragangliomas. The establishment of the therapeutic approach should incorporate the results of such an investigation. OBJECTIVE: To establish criteria for benignancy and malignancy of vagal and jugular-tympanic paragangliomas, via the study of the relationships of sex, age, tumor size, duration of complaints, site, family history, presence of metastases, treatment, histological architecture and cell type with the immunohistochemical reactions to S100 protein, chromogranin and AgKi67. DESIGN: A retrospective study of histological and clinical records. SETTING: The Heliópolis and Oswaldo Cruz tertiary general hospitals, São Paulo. SAMPLE: 8 cases of head and neck paragangliomas. MAIN MEASUREMENTS: Determination of degree of positivity to paragangliomas via immunohistochemical reactions. RESULTS: 1). The protein markers for the principal cells (AgKi67 and chromogranin) were sensitive in 100% of the tumors when used together. 2). S100 protein was well identified in the cytoplasm and nucleus of sustentacular cells and underwent reduction in the neoplasias. CONCLUSIONS: Chromogranin was proven to be a generic marker for neuroendocrine tumors; S100 protein was positive in all 8 cases and the AgKi67 had low positivity in all cases.
id APM-1_e77415300de69929f06e2619b6ba5efd
oai_identifier_str oai:scielo:S1516-31802001000300006
network_acronym_str APM-1
network_name_str São Paulo medical journal (Online)
repository_id_str
spelling Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspectsParagangliomasMarkersAgKi67ChromograninS100 proteinCONTEXT: Protein marker positivity can assist in the definition of the therapeutic approach towards head and neck paragangliomas. The establishment of the therapeutic approach should incorporate the results of such an investigation. OBJECTIVE: To establish criteria for benignancy and malignancy of vagal and jugular-tympanic paragangliomas, via the study of the relationships of sex, age, tumor size, duration of complaints, site, family history, presence of metastases, treatment, histological architecture and cell type with the immunohistochemical reactions to S100 protein, chromogranin and AgKi67. DESIGN: A retrospective study of histological and clinical records. SETTING: The Heliópolis and Oswaldo Cruz tertiary general hospitals, São Paulo. SAMPLE: 8 cases of head and neck paragangliomas. MAIN MEASUREMENTS: Determination of degree of positivity to paragangliomas via immunohistochemical reactions. RESULTS: 1). The protein markers for the principal cells (AgKi67 and chromogranin) were sensitive in 100% of the tumors when used together. 2). S100 protein was well identified in the cytoplasm and nucleus of sustentacular cells and underwent reduction in the neoplasias. CONCLUSIONS: Chromogranin was proven to be a generic marker for neuroendocrine tumors; S100 protein was positive in all 8 cases and the AgKi67 had low positivity in all cases.Associação Paulista de Medicina - APM2001-05-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000300006Sao Paulo Medical Journal v.119 n.3 2001reponame:São Paulo medical journal (Online)instname:Associação Paulista de Medicinainstacron:APM10.1590/S1516-31802001000300006info:eu-repo/semantics/openAccessAndrade Filho,Pedro de Alcântara deRapoport,AbrãoAlves,Venâncio Avancini FerreiraDenardin,Odilon Victor PortoAndrade Sobrinho,Josias deCarvalho,Marcos Brasilino deeng2001-05-30T00:00:00Zoai:scielo:S1516-31802001000300006Revistahttp://www.scielo.br/spmjhttps://old.scielo.br/oai/scielo-oai.phprevistas@apm.org.br1806-94601516-3180opendoar:2001-05-30T00:00São Paulo medical journal (Online) - Associação Paulista de Medicinafalse
dc.title.none.fl_str_mv Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects
title Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects
spellingShingle Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects
Andrade Filho,Pedro de Alcântara de
Paragangliomas
Markers
AgKi67
Chromogranin
S100 protein
title_short Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects
title_full Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects
title_fullStr Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects
title_full_unstemmed Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects
title_sort Paragangliomas of the head and neck: clinical, morphological and immunohistochemical aspects
author Andrade Filho,Pedro de Alcântara de
author_facet Andrade Filho,Pedro de Alcântara de
Rapoport,Abrão
Alves,Venâncio Avancini Ferreira
Denardin,Odilon Victor Porto
Andrade Sobrinho,Josias de
Carvalho,Marcos Brasilino de
author_role author
author2 Rapoport,Abrão
Alves,Venâncio Avancini Ferreira
Denardin,Odilon Victor Porto
Andrade Sobrinho,Josias de
Carvalho,Marcos Brasilino de
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade Filho,Pedro de Alcântara de
Rapoport,Abrão
Alves,Venâncio Avancini Ferreira
Denardin,Odilon Victor Porto
Andrade Sobrinho,Josias de
Carvalho,Marcos Brasilino de
dc.subject.por.fl_str_mv Paragangliomas
Markers
AgKi67
Chromogranin
S100 protein
topic Paragangliomas
Markers
AgKi67
Chromogranin
S100 protein
description CONTEXT: Protein marker positivity can assist in the definition of the therapeutic approach towards head and neck paragangliomas. The establishment of the therapeutic approach should incorporate the results of such an investigation. OBJECTIVE: To establish criteria for benignancy and malignancy of vagal and jugular-tympanic paragangliomas, via the study of the relationships of sex, age, tumor size, duration of complaints, site, family history, presence of metastases, treatment, histological architecture and cell type with the immunohistochemical reactions to S100 protein, chromogranin and AgKi67. DESIGN: A retrospective study of histological and clinical records. SETTING: The Heliópolis and Oswaldo Cruz tertiary general hospitals, São Paulo. SAMPLE: 8 cases of head and neck paragangliomas. MAIN MEASUREMENTS: Determination of degree of positivity to paragangliomas via immunohistochemical reactions. RESULTS: 1). The protein markers for the principal cells (AgKi67 and chromogranin) were sensitive in 100% of the tumors when used together. 2). S100 protein was well identified in the cytoplasm and nucleus of sustentacular cells and underwent reduction in the neoplasias. CONCLUSIONS: Chromogranin was proven to be a generic marker for neuroendocrine tumors; S100 protein was positive in all 8 cases and the AgKi67 had low positivity in all cases.
publishDate 2001
dc.date.none.fl_str_mv 2001-05-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000300006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1516-31802001000300006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv Sao Paulo Medical Journal v.119 n.3 2001
reponame:São Paulo medical journal (Online)
instname:Associação Paulista de Medicina
instacron:APM
instname_str Associação Paulista de Medicina
instacron_str APM
institution APM
reponame_str São Paulo medical journal (Online)
collection São Paulo medical journal (Online)
repository.name.fl_str_mv São Paulo medical journal (Online) - Associação Paulista de Medicina
repository.mail.fl_str_mv revistas@apm.org.br
_version_ 1754209260376424448