Green process in benzoic acid derivatives synthesis/ Processo verde em síntese de derivados de ácido benzoico
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Brazilian Applied Science Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/38372 |
Resumo: | Employing a methodology that meets various requirements of "Green Chemistry", the substances quinazolinyl benzoate (P1) and N-4-imidazolphenylbenzamide (P2) were synthesized through benzoylation reactions by the classical Schotten-Baumann method, in an aqueous environment and room temperature. The products were purified by recrystallization and characterized by melting point, thin layer chromatography (TLC) and infrared spectroscopy. Qualitative antioxidant activities with the diphenylpicrylhydrazyl radical (DPPH) and toxic potential against Artemia salina Leach larvae were also investigated. Only P2 indicated significant antioxidant activity. According to the medium lethal concentration values (LC50), used for P1 and P2, the toxic potential revealed, respectively, to be moderate for P1 and weak for P2. Despite the low yield obtained for the synthesis of P1, the characterizations indicate success in the preparations, within a synthetic strategy of low cost, efficient and ecologically sustainable. |
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Green process in benzoic acid derivatives synthesis/ Processo verde em síntese de derivados de ácido benzoicoGreen synthesis. Toxic potential. Antioxidant activity.Employing a methodology that meets various requirements of "Green Chemistry", the substances quinazolinyl benzoate (P1) and N-4-imidazolphenylbenzamide (P2) were synthesized through benzoylation reactions by the classical Schotten-Baumann method, in an aqueous environment and room temperature. The products were purified by recrystallization and characterized by melting point, thin layer chromatography (TLC) and infrared spectroscopy. Qualitative antioxidant activities with the diphenylpicrylhydrazyl radical (DPPH) and toxic potential against Artemia salina Leach larvae were also investigated. Only P2 indicated significant antioxidant activity. According to the medium lethal concentration values (LC50), used for P1 and P2, the toxic potential revealed, respectively, to be moderate for P1 and weak for P2. Despite the low yield obtained for the synthesis of P1, the characterizations indicate success in the preparations, within a synthetic strategy of low cost, efficient and ecologically sustainable.Brazilian Journals Publicações de Periódicos e Editora Ltda.2021-10-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/3837210.34115/basrv5n5-004Brazilian Applied Science Review; Vol. 5 No. 5 (2021); 2016-2028Brazilian Applied Science Review; v. 5 n. 5 (2021); 2016-20282595-36212595-362110.34115/basr.v5i5reponame:Brazilian Applied Science Reviewinstname:Brazilian Journals Publicações de Periódicos e Editora Ltdainstacron:FIEPporhttps://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/38372/pdfCopyright (c) 2021 Brazilian Applied Science Reviewinfo:eu-repo/semantics/openAccessSantos, Jaciel Gonçalves dosSilva, Adriany daJunior, Jair MarquesBatalini, Claudemir2021-11-03T11:19:12Zoai:ojs2.ojs.brazilianjournals.com.br:article/38372Revistahttps://www.brazilianjournals.com/index.php/BASRPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BASR/oaibrazilianasr@yahoo.com || brazilianasr@yahoo.com2595-36212595-3621opendoar:2021-11-03T11:19:12Brazilian Applied Science Review - Brazilian Journals Publicações de Periódicos e Editora Ltdafalse |
dc.title.none.fl_str_mv |
Green process in benzoic acid derivatives synthesis/ Processo verde em síntese de derivados de ácido benzoico |
title |
Green process in benzoic acid derivatives synthesis/ Processo verde em síntese de derivados de ácido benzoico |
spellingShingle |
Green process in benzoic acid derivatives synthesis/ Processo verde em síntese de derivados de ácido benzoico Santos, Jaciel Gonçalves dos Green synthesis. Toxic potential. Antioxidant activity. |
title_short |
Green process in benzoic acid derivatives synthesis/ Processo verde em síntese de derivados de ácido benzoico |
title_full |
Green process in benzoic acid derivatives synthesis/ Processo verde em síntese de derivados de ácido benzoico |
title_fullStr |
Green process in benzoic acid derivatives synthesis/ Processo verde em síntese de derivados de ácido benzoico |
title_full_unstemmed |
Green process in benzoic acid derivatives synthesis/ Processo verde em síntese de derivados de ácido benzoico |
title_sort |
Green process in benzoic acid derivatives synthesis/ Processo verde em síntese de derivados de ácido benzoico |
author |
Santos, Jaciel Gonçalves dos |
author_facet |
Santos, Jaciel Gonçalves dos Silva, Adriany da Junior, Jair Marques Batalini, Claudemir |
author_role |
author |
author2 |
Silva, Adriany da Junior, Jair Marques Batalini, Claudemir |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Santos, Jaciel Gonçalves dos Silva, Adriany da Junior, Jair Marques Batalini, Claudemir |
dc.subject.por.fl_str_mv |
Green synthesis. Toxic potential. Antioxidant activity. |
topic |
Green synthesis. Toxic potential. Antioxidant activity. |
description |
Employing a methodology that meets various requirements of "Green Chemistry", the substances quinazolinyl benzoate (P1) and N-4-imidazolphenylbenzamide (P2) were synthesized through benzoylation reactions by the classical Schotten-Baumann method, in an aqueous environment and room temperature. The products were purified by recrystallization and characterized by melting point, thin layer chromatography (TLC) and infrared spectroscopy. Qualitative antioxidant activities with the diphenylpicrylhydrazyl radical (DPPH) and toxic potential against Artemia salina Leach larvae were also investigated. Only P2 indicated significant antioxidant activity. According to the medium lethal concentration values (LC50), used for P1 and P2, the toxic potential revealed, respectively, to be moderate for P1 and weak for P2. Despite the low yield obtained for the synthesis of P1, the characterizations indicate success in the preparations, within a synthetic strategy of low cost, efficient and ecologically sustainable. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-10-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/38372 10.34115/basrv5n5-004 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/38372 |
identifier_str_mv |
10.34115/basrv5n5-004 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BASR/article/view/38372/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2021 Brazilian Applied Science Review info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2021 Brazilian Applied Science Review |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Applied Science Review; Vol. 5 No. 5 (2021); 2016-2028 Brazilian Applied Science Review; v. 5 n. 5 (2021); 2016-2028 2595-3621 2595-3621 10.34115/basr.v5i5 reponame:Brazilian Applied Science Review instname:Brazilian Journals Publicações de Periódicos e Editora Ltda instacron:FIEP |
instname_str |
Brazilian Journals Publicações de Periódicos e Editora Ltda |
instacron_str |
FIEP |
institution |
FIEP |
reponame_str |
Brazilian Applied Science Review |
collection |
Brazilian Applied Science Review |
repository.name.fl_str_mv |
Brazilian Applied Science Review - Brazilian Journals Publicações de Periódicos e Editora Ltda |
repository.mail.fl_str_mv |
brazilianasr@yahoo.com || brazilianasr@yahoo.com |
_version_ |
1797240008323629056 |