POEMS Syndrome: a clinical challenge / Síndrome de POEMS: um desafio clínico
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/43894 |
Resumo: | A 42-year-old male patient admitted to our service with a history of progressive and symmetrical weakness, paresthesia of the lower limbs, weight loss and urinary retention for about 8 months. Physical examination demonstrated poor general condition, lower limb edema, hepatomegaly and digital clubbing. Neurological examination showed a polyneuropathic pattern, with hypoesthesia and absence of deep reflexes of the lower limbs. Initial laboratory investigation demonstrated erythrocytosis and thyroid and adrenal dysfunction in addition to hypergammaglobulinemia. CSF analysis, due to the clinical suspicion of chronic inflammatory demyelinating polyneuropathy, resulted in protein-cytological dissociation. PIDC was hypothesized to be due to light-chain disease, but for this association we supplemented with bone marrow analysis and whole-body CT scan, which showed 4% atypia in plasma cells and osteolytic and osteoblastic lesions in the vertebro-costal region between the 8th and 9th vertebrae. Subsequent biopsy confirmed plasmacytoma. He performed autologous bone marrow transplantation, but evolved with infectious complications and died within 3 months. |
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Brazilian Journal of Health Review |
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POEMS Syndrome: a clinical challenge / Síndrome de POEMS: um desafio clínicoPOEMS syndromechronic inflammatory demyelinating polyneuropathyhypergammaglobulinemiaA 42-year-old male patient admitted to our service with a history of progressive and symmetrical weakness, paresthesia of the lower limbs, weight loss and urinary retention for about 8 months. Physical examination demonstrated poor general condition, lower limb edema, hepatomegaly and digital clubbing. Neurological examination showed a polyneuropathic pattern, with hypoesthesia and absence of deep reflexes of the lower limbs. Initial laboratory investigation demonstrated erythrocytosis and thyroid and adrenal dysfunction in addition to hypergammaglobulinemia. CSF analysis, due to the clinical suspicion of chronic inflammatory demyelinating polyneuropathy, resulted in protein-cytological dissociation. PIDC was hypothesized to be due to light-chain disease, but for this association we supplemented with bone marrow analysis and whole-body CT scan, which showed 4% atypia in plasma cells and osteolytic and osteoblastic lesions in the vertebro-costal region between the 8th and 9th vertebrae. Subsequent biopsy confirmed plasmacytoma. He performed autologous bone marrow transplantation, but evolved with infectious complications and died within 3 months.Brazilian Journals Publicações de Periódicos e Editora Ltda.2022-02-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/4389410.34119/bjhrv5n1-232Brazilian Journal of Health Review; Vol. 5 No. 1 (2022); 2585-2587Brazilian Journal of Health Review; v. 5 n. 1 (2022); 2585-25872595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/43894/pdfCopyright (c) 2022 Brazilian Journal of Health Reviewinfo:eu-repo/semantics/openAccessBrito, Vanessa de SousaFreua, FernandoFreitas, Christian Henrique de Andrade2022-02-28T20:37:31Zoai:ojs2.ojs.brazilianjournals.com.br:article/43894Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2022-02-28T20:37:31Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
POEMS Syndrome: a clinical challenge / Síndrome de POEMS: um desafio clínico |
title |
POEMS Syndrome: a clinical challenge / Síndrome de POEMS: um desafio clínico |
spellingShingle |
POEMS Syndrome: a clinical challenge / Síndrome de POEMS: um desafio clínico Brito, Vanessa de Sousa POEMS syndrome chronic inflammatory demyelinating polyneuropathy hypergammaglobulinemia |
title_short |
POEMS Syndrome: a clinical challenge / Síndrome de POEMS: um desafio clínico |
title_full |
POEMS Syndrome: a clinical challenge / Síndrome de POEMS: um desafio clínico |
title_fullStr |
POEMS Syndrome: a clinical challenge / Síndrome de POEMS: um desafio clínico |
title_full_unstemmed |
POEMS Syndrome: a clinical challenge / Síndrome de POEMS: um desafio clínico |
title_sort |
POEMS Syndrome: a clinical challenge / Síndrome de POEMS: um desafio clínico |
author |
Brito, Vanessa de Sousa |
author_facet |
Brito, Vanessa de Sousa Freua, Fernando Freitas, Christian Henrique de Andrade |
author_role |
author |
author2 |
Freua, Fernando Freitas, Christian Henrique de Andrade |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Brito, Vanessa de Sousa Freua, Fernando Freitas, Christian Henrique de Andrade |
dc.subject.por.fl_str_mv |
POEMS syndrome chronic inflammatory demyelinating polyneuropathy hypergammaglobulinemia |
topic |
POEMS syndrome chronic inflammatory demyelinating polyneuropathy hypergammaglobulinemia |
description |
A 42-year-old male patient admitted to our service with a history of progressive and symmetrical weakness, paresthesia of the lower limbs, weight loss and urinary retention for about 8 months. Physical examination demonstrated poor general condition, lower limb edema, hepatomegaly and digital clubbing. Neurological examination showed a polyneuropathic pattern, with hypoesthesia and absence of deep reflexes of the lower limbs. Initial laboratory investigation demonstrated erythrocytosis and thyroid and adrenal dysfunction in addition to hypergammaglobulinemia. CSF analysis, due to the clinical suspicion of chronic inflammatory demyelinating polyneuropathy, resulted in protein-cytological dissociation. PIDC was hypothesized to be due to light-chain disease, but for this association we supplemented with bone marrow analysis and whole-body CT scan, which showed 4% atypia in plasma cells and osteolytic and osteoblastic lesions in the vertebro-costal region between the 8th and 9th vertebrae. Subsequent biopsy confirmed plasmacytoma. He performed autologous bone marrow transplantation, but evolved with infectious complications and died within 3 months. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/43894 10.34119/bjhrv5n1-232 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/43894 |
identifier_str_mv |
10.34119/bjhrv5n1-232 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/43894/pdf |
dc.rights.driver.fl_str_mv |
Copyright (c) 2022 Brazilian Journal of Health Review info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2022 Brazilian Journal of Health Review |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 5 No. 1 (2022); 2585-2587 Brazilian Journal of Health Review; v. 5 n. 1 (2022); 2585-2587 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
_version_ |
1797240072310882304 |