Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review

Detalhes bibliográficos
Autor(a) principal: Dias, Maria Júlia Lima Eugenio
Data de Publicação: 2023
Outros Autores: Pereira, Bruna Letícia Buzati, Orrico, Silvana Regina Perez
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Health Review
DOI: 10.34119/bjhrv6n3-091
Texto Completo: https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/59747
Resumo: Background/Purpose: Type 2 diabetes mellitus (T2DM) is a worldwide pathology with several complications, and 50% of patients with T2DM develop peripheral neuropathy (PN) in the long term. The present study aimed to review the literature on the association between PN and vitamin B12 deficiency in patients with T2DM treated with metformin.  Materials and methods: A literature review was carried out in the PubMed Central, Cochrane, Scielo, Scopus and Embase databases, from 2015 to 2021. We found 755 studies, of which 16 were included. Results: The serum level of vitamin B12 was lower in individuals with at least one neurological symptom. Treatment with metformin was associated with reduced serum vitamin B12 levels, and its use was defined as a probable cause of PN due to reduced vitamin B12. Studies that performed supplementation with methylcobalamin demonstrated significant improvement in neuropathic symptoms. Vitamin B12 supplementation therapy for diabetic patients undergoing metformin treatment has been suggested. Conclusion: Deficiency of vitamin B12 associated to metformin can be considered a risk factor for PN. Periodically evaluation of serum levels of vitamin B12 is recommended for patients on metformin treatment.
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spelling Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative reviewDiabetic mellitusDiabetic neuropathyMetforminPeripheral neuropathyVitamin B12 deficiencyBackground/Purpose: Type 2 diabetes mellitus (T2DM) is a worldwide pathology with several complications, and 50% of patients with T2DM develop peripheral neuropathy (PN) in the long term. The present study aimed to review the literature on the association between PN and vitamin B12 deficiency in patients with T2DM treated with metformin.  Materials and methods: A literature review was carried out in the PubMed Central, Cochrane, Scielo, Scopus and Embase databases, from 2015 to 2021. We found 755 studies, of which 16 were included. Results: The serum level of vitamin B12 was lower in individuals with at least one neurological symptom. Treatment with metformin was associated with reduced serum vitamin B12 levels, and its use was defined as a probable cause of PN due to reduced vitamin B12. Studies that performed supplementation with methylcobalamin demonstrated significant improvement in neuropathic symptoms. Vitamin B12 supplementation therapy for diabetic patients undergoing metformin treatment has been suggested. Conclusion: Deficiency of vitamin B12 associated to metformin can be considered a risk factor for PN. Periodically evaluation of serum levels of vitamin B12 is recommended for patients on metformin treatment.Brazilian Journals Publicações de Periódicos e Editora Ltda.2023-05-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/5974710.34119/bjhrv6n3-091Brazilian Journal of Health Review; Vol. 6 No. 3 (2023); 9534-9548Brazilian Journal of Health Review; Vol. 6 Núm. 3 (2023); 9534-9548Brazilian Journal of Health Review; v. 6 n. 3 (2023); 9534-95482595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/59747/43189Dias, Maria Júlia Lima EugenioPereira, Bruna Letícia BuzatiOrrico, Silvana Regina Perezinfo:eu-repo/semantics/openAccess2023-06-21T14:57:15Zoai:ojs2.ojs.brazilianjournals.com.br:article/59747Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2023-06-21T14:57:15Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false
dc.title.none.fl_str_mv Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review
title Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review
spellingShingle Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review
Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review
Dias, Maria Júlia Lima Eugenio
Diabetic mellitus
Diabetic neuropathy
Metformin
Peripheral neuropathy
Vitamin B12 deficiency
Dias, Maria Júlia Lima Eugenio
Diabetic mellitus
Diabetic neuropathy
Metformin
Peripheral neuropathy
Vitamin B12 deficiency
title_short Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review
title_full Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review
title_fullStr Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review
Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review
title_full_unstemmed Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review
Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review
title_sort Vitamin B12 Deficiency and Peripheral Neuropathy in patients with Type 2 Diabetes Mellitus Treated with Metformin. An integrative review
author Dias, Maria Júlia Lima Eugenio
author_facet Dias, Maria Júlia Lima Eugenio
Dias, Maria Júlia Lima Eugenio
Pereira, Bruna Letícia Buzati
Orrico, Silvana Regina Perez
Pereira, Bruna Letícia Buzati
Orrico, Silvana Regina Perez
author_role author
author2 Pereira, Bruna Letícia Buzati
Orrico, Silvana Regina Perez
author2_role author
author
dc.contributor.author.fl_str_mv Dias, Maria Júlia Lima Eugenio
Pereira, Bruna Letícia Buzati
Orrico, Silvana Regina Perez
dc.subject.por.fl_str_mv Diabetic mellitus
Diabetic neuropathy
Metformin
Peripheral neuropathy
Vitamin B12 deficiency
topic Diabetic mellitus
Diabetic neuropathy
Metformin
Peripheral neuropathy
Vitamin B12 deficiency
description Background/Purpose: Type 2 diabetes mellitus (T2DM) is a worldwide pathology with several complications, and 50% of patients with T2DM develop peripheral neuropathy (PN) in the long term. The present study aimed to review the literature on the association between PN and vitamin B12 deficiency in patients with T2DM treated with metformin.  Materials and methods: A literature review was carried out in the PubMed Central, Cochrane, Scielo, Scopus and Embase databases, from 2015 to 2021. We found 755 studies, of which 16 were included. Results: The serum level of vitamin B12 was lower in individuals with at least one neurological symptom. Treatment with metformin was associated with reduced serum vitamin B12 levels, and its use was defined as a probable cause of PN due to reduced vitamin B12. Studies that performed supplementation with methylcobalamin demonstrated significant improvement in neuropathic symptoms. Vitamin B12 supplementation therapy for diabetic patients undergoing metformin treatment has been suggested. Conclusion: Deficiency of vitamin B12 associated to metformin can be considered a risk factor for PN. Periodically evaluation of serum levels of vitamin B12 is recommended for patients on metformin treatment.
publishDate 2023
dc.date.none.fl_str_mv 2023-05-15
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/59747
10.34119/bjhrv6n3-091
url https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/59747
identifier_str_mv 10.34119/bjhrv6n3-091
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/59747/43189
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
publisher.none.fl_str_mv Brazilian Journals Publicações de Periódicos e Editora Ltda.
dc.source.none.fl_str_mv Brazilian Journal of Health Review; Vol. 6 No. 3 (2023); 9534-9548
Brazilian Journal of Health Review; Vol. 6 Núm. 3 (2023); 9534-9548
Brazilian Journal of Health Review; v. 6 n. 3 (2023); 9534-9548
2595-6825
reponame:Brazilian Journal of Health Review
instname:Federação das Indústrias do Estado do Paraná (FIEP)
instacron:BJRH
instname_str Federação das Indústrias do Estado do Paraná (FIEP)
instacron_str BJRH
institution BJRH
reponame_str Brazilian Journal of Health Review
collection Brazilian Journal of Health Review
repository.name.fl_str_mv Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)
repository.mail.fl_str_mv || brazilianjhr@gmail.com
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dc.identifier.doi.none.fl_str_mv 10.34119/bjhrv6n3-091