Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
DOI: | 10.3390/nu12010250 |
Texto Completo: | http://hdl.handle.net/10316/106518 https://doi.org/10.3390/nu12010250 |
Resumo: | Unhealthy dietary habits are major modifiable risk factors for the development of type 2 diabetes mellitus, a metabolic disease with increasing prevalence and serious consequences. Microvascular complications of diabetes, namely diabetic peripheral neuropathy (DPN), retinopathy (DR), and nephropathy (DN), are associated with high morbidity rates and a heavy social and economic burden. Currently, available therapeutic options to counter the evolution of diabetic microvascular complications are clearly insufficient, which strongly recommends further research. Animal models are essential tools to dissect the molecular mechanisms underlying disease progression, to unravel new therapeutic targets, as well as to evaluate the efficacy of new drugs and/or novel therapeutic approaches. However, choosing the best animal model is challenging due to the large number of factors that need to be considered. This is particularly relevant for models induced by dietary modifications, which vary markedly in terms of macronutrient composition. In this article, we revisit the rodent models of diet-induced DPN, DR, and DN, critically comparing the main features of these microvascular complications in humans and the criteria for their diagnosis with the parameters that have been used in preclinical research using rodent models, considering the possible need for factors which can accelerate or aggravate these conditions. |
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Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathytype 2 diabetes mellitusmicrovascular complicationsdiabetic peripheral neuropathydiabetic retinopathydiabetic nephropathyrodent modelsdiet-inducedUnhealthy dietary habits are major modifiable risk factors for the development of type 2 diabetes mellitus, a metabolic disease with increasing prevalence and serious consequences. Microvascular complications of diabetes, namely diabetic peripheral neuropathy (DPN), retinopathy (DR), and nephropathy (DN), are associated with high morbidity rates and a heavy social and economic burden. Currently, available therapeutic options to counter the evolution of diabetic microvascular complications are clearly insufficient, which strongly recommends further research. Animal models are essential tools to dissect the molecular mechanisms underlying disease progression, to unravel new therapeutic targets, as well as to evaluate the efficacy of new drugs and/or novel therapeutic approaches. However, choosing the best animal model is challenging due to the large number of factors that need to be considered. This is particularly relevant for models induced by dietary modifications, which vary markedly in terms of macronutrient composition. In this article, we revisit the rodent models of diet-induced DPN, DR, and DN, critically comparing the main features of these microvascular complications in humans and the criteria for their diagnosis with the parameters that have been used in preclinical research using rodent models, considering the possible need for factors which can accelerate or aggravate these conditions.MDPI2020-01-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106518http://hdl.handle.net/10316/106518https://doi.org/10.3390/nu12010250eng2072-6643319637092072-6643Preguiça, InêsAlves, AndréNunes, SaraGomes, PedroFernandes, RosaViana, Sofia D.Reis, Flávioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-10T20:43:33Zoai:estudogeral.uc.pt:10316/106518Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:57.854614Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy |
title |
Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy |
spellingShingle |
Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy Preguiça, Inês type 2 diabetes mellitus microvascular complications diabetic peripheral neuropathy diabetic retinopathy diabetic nephropathy rodent models diet-induced Preguiça, Inês type 2 diabetes mellitus microvascular complications diabetic peripheral neuropathy diabetic retinopathy diabetic nephropathy rodent models diet-induced |
title_short |
Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy |
title_full |
Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy |
title_fullStr |
Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy |
title_full_unstemmed |
Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy |
title_sort |
Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy |
author |
Preguiça, Inês |
author_facet |
Preguiça, Inês Preguiça, Inês Alves, André Nunes, Sara Gomes, Pedro Fernandes, Rosa Viana, Sofia D. Reis, Flávio Alves, André Nunes, Sara Gomes, Pedro Fernandes, Rosa Viana, Sofia D. Reis, Flávio |
author_role |
author |
author2 |
Alves, André Nunes, Sara Gomes, Pedro Fernandes, Rosa Viana, Sofia D. Reis, Flávio |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Preguiça, Inês Alves, André Nunes, Sara Gomes, Pedro Fernandes, Rosa Viana, Sofia D. Reis, Flávio |
dc.subject.por.fl_str_mv |
type 2 diabetes mellitus microvascular complications diabetic peripheral neuropathy diabetic retinopathy diabetic nephropathy rodent models diet-induced |
topic |
type 2 diabetes mellitus microvascular complications diabetic peripheral neuropathy diabetic retinopathy diabetic nephropathy rodent models diet-induced |
description |
Unhealthy dietary habits are major modifiable risk factors for the development of type 2 diabetes mellitus, a metabolic disease with increasing prevalence and serious consequences. Microvascular complications of diabetes, namely diabetic peripheral neuropathy (DPN), retinopathy (DR), and nephropathy (DN), are associated with high morbidity rates and a heavy social and economic burden. Currently, available therapeutic options to counter the evolution of diabetic microvascular complications are clearly insufficient, which strongly recommends further research. Animal models are essential tools to dissect the molecular mechanisms underlying disease progression, to unravel new therapeutic targets, as well as to evaluate the efficacy of new drugs and/or novel therapeutic approaches. However, choosing the best animal model is challenging due to the large number of factors that need to be considered. This is particularly relevant for models induced by dietary modifications, which vary markedly in terms of macronutrient composition. In this article, we revisit the rodent models of diet-induced DPN, DR, and DN, critically comparing the main features of these microvascular complications in humans and the criteria for their diagnosis with the parameters that have been used in preclinical research using rodent models, considering the possible need for factors which can accelerate or aggravate these conditions. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-18 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/106518 http://hdl.handle.net/10316/106518 https://doi.org/10.3390/nu12010250 |
url |
http://hdl.handle.net/10316/106518 https://doi.org/10.3390/nu12010250 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2072-6643 31963709 2072-6643 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1822218240438304768 |
dc.identifier.doi.none.fl_str_mv |
10.3390/nu12010250 |