Effectiveness of the use of non-hydrolysed type II collagen in the treatment of osteoarthritis: a systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Health Review |
Texto Completo: | https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/56647 |
Resumo: | Objective: To evaluate the effectiveness of treating osteoarthritis with the use of type II non-denatured collagen (UCII). Methods: This is a study of systematic review and meta-analysis based on searches for randomized controlled clinical trials carried out in the PUBMED, SciELO, ScienceDirect and Google Scholar databases. 2009 and 2020 studies that analyzed the effectiveness of UCII in the treatment of patients with osteoarthritis using clinical and / or radiographic criteria and based on WOMAC and VAS scores were included. Results: A total of 4.850 references were found in the literature. When applying the inclusion criteria, there were only 4 studies suitable for selection, and 3 of them were possible to be included in the meta-analysis. All studies were carried out in patients with knee osteoarthritis and the total sample was 202 patients. Meta-analysis of WOMAC and VAS scores was performed in the three independent studies according to the intervention adopted, and heterogeneity was not significant in both (τ² = 0.0; I² = 0%). In the WOMAC and VAS scores, the point estimate for the difference in standardized means was -0.44 (95% CI=-0.72 to -0.16; 0.002) and -0.37 (95% CI = - 0.65 to -0.09; 0.010) respectively, thus, the intervention group had positive effects and favorable results compared to the control group. There was no publication bias for the WOMAC and VAS outcomes; Conclusion: Based on the results of this study, the use of the UCII is effective in the treatment of osteoarthritis to improve parameters of pain and mobility on WOMAC and VAS parameters. |
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Brazilian Journal of Health Review |
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Effectiveness of the use of non-hydrolysed type II collagen in the treatment of osteoarthritis: a systematic review and meta-analysisosteoarthritistreatmentUC-IIObjective: To evaluate the effectiveness of treating osteoarthritis with the use of type II non-denatured collagen (UCII). Methods: This is a study of systematic review and meta-analysis based on searches for randomized controlled clinical trials carried out in the PUBMED, SciELO, ScienceDirect and Google Scholar databases. 2009 and 2020 studies that analyzed the effectiveness of UCII in the treatment of patients with osteoarthritis using clinical and / or radiographic criteria and based on WOMAC and VAS scores were included. Results: A total of 4.850 references were found in the literature. When applying the inclusion criteria, there were only 4 studies suitable for selection, and 3 of them were possible to be included in the meta-analysis. All studies were carried out in patients with knee osteoarthritis and the total sample was 202 patients. Meta-analysis of WOMAC and VAS scores was performed in the three independent studies according to the intervention adopted, and heterogeneity was not significant in both (τ² = 0.0; I² = 0%). In the WOMAC and VAS scores, the point estimate for the difference in standardized means was -0.44 (95% CI=-0.72 to -0.16; 0.002) and -0.37 (95% CI = - 0.65 to -0.09; 0.010) respectively, thus, the intervention group had positive effects and favorable results compared to the control group. There was no publication bias for the WOMAC and VAS outcomes; Conclusion: Based on the results of this study, the use of the UCII is effective in the treatment of osteoarthritis to improve parameters of pain and mobility on WOMAC and VAS parameters.Brazilian Journals Publicações de Periódicos e Editora Ltda.2023-01-24info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/5664710.34119/bjhrv6n1-131Brazilian Journal of Health Review; Vol. 6 No. 1 (2023); 1649-1660Brazilian Journal of Health Review; Vol. 6 Núm. 1 (2023); 1649-1660Brazilian Journal of Health Review; v. 6 n. 1 (2023); 1649-16602595-6825reponame:Brazilian Journal of Health Reviewinstname:Federação das Indústrias do Estado do Paraná (FIEP)instacron:BJRHenghttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/56647/41549Sadigursky, DavidSanches, Mário MartinsGarcia, Nathalia MachadoCantão, Mariana de OliveiraMatos, Marcos Almeidainfo:eu-repo/semantics/openAccess2023-02-15T18:17:51Zoai:ojs2.ojs.brazilianjournals.com.br:article/56647Revistahttp://www.brazilianjournals.com/index.php/BJHR/indexPRIhttps://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/oai|| brazilianjhr@gmail.com2595-68252595-6825opendoar:2023-02-15T18:17:51Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP)false |
dc.title.none.fl_str_mv |
Effectiveness of the use of non-hydrolysed type II collagen in the treatment of osteoarthritis: a systematic review and meta-analysis |
title |
Effectiveness of the use of non-hydrolysed type II collagen in the treatment of osteoarthritis: a systematic review and meta-analysis |
spellingShingle |
Effectiveness of the use of non-hydrolysed type II collagen in the treatment of osteoarthritis: a systematic review and meta-analysis Sadigursky, David osteoarthritis treatment UC-II |
title_short |
Effectiveness of the use of non-hydrolysed type II collagen in the treatment of osteoarthritis: a systematic review and meta-analysis |
title_full |
Effectiveness of the use of non-hydrolysed type II collagen in the treatment of osteoarthritis: a systematic review and meta-analysis |
title_fullStr |
Effectiveness of the use of non-hydrolysed type II collagen in the treatment of osteoarthritis: a systematic review and meta-analysis |
title_full_unstemmed |
Effectiveness of the use of non-hydrolysed type II collagen in the treatment of osteoarthritis: a systematic review and meta-analysis |
title_sort |
Effectiveness of the use of non-hydrolysed type II collagen in the treatment of osteoarthritis: a systematic review and meta-analysis |
author |
Sadigursky, David |
author_facet |
Sadigursky, David Sanches, Mário Martins Garcia, Nathalia Machado Cantão, Mariana de Oliveira Matos, Marcos Almeida |
author_role |
author |
author2 |
Sanches, Mário Martins Garcia, Nathalia Machado Cantão, Mariana de Oliveira Matos, Marcos Almeida |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Sadigursky, David Sanches, Mário Martins Garcia, Nathalia Machado Cantão, Mariana de Oliveira Matos, Marcos Almeida |
dc.subject.por.fl_str_mv |
osteoarthritis treatment UC-II |
topic |
osteoarthritis treatment UC-II |
description |
Objective: To evaluate the effectiveness of treating osteoarthritis with the use of type II non-denatured collagen (UCII). Methods: This is a study of systematic review and meta-analysis based on searches for randomized controlled clinical trials carried out in the PUBMED, SciELO, ScienceDirect and Google Scholar databases. 2009 and 2020 studies that analyzed the effectiveness of UCII in the treatment of patients with osteoarthritis using clinical and / or radiographic criteria and based on WOMAC and VAS scores were included. Results: A total of 4.850 references were found in the literature. When applying the inclusion criteria, there were only 4 studies suitable for selection, and 3 of them were possible to be included in the meta-analysis. All studies were carried out in patients with knee osteoarthritis and the total sample was 202 patients. Meta-analysis of WOMAC and VAS scores was performed in the three independent studies according to the intervention adopted, and heterogeneity was not significant in both (τ² = 0.0; I² = 0%). In the WOMAC and VAS scores, the point estimate for the difference in standardized means was -0.44 (95% CI=-0.72 to -0.16; 0.002) and -0.37 (95% CI = - 0.65 to -0.09; 0.010) respectively, thus, the intervention group had positive effects and favorable results compared to the control group. There was no publication bias for the WOMAC and VAS outcomes; Conclusion: Based on the results of this study, the use of the UCII is effective in the treatment of osteoarthritis to improve parameters of pain and mobility on WOMAC and VAS parameters. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-01-24 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/56647 10.34119/bjhrv6n1-131 |
url |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/56647 |
identifier_str_mv |
10.34119/bjhrv6n1-131 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://ojs.brazilianjournals.com.br/ojs/index.php/BJHR/article/view/56647/41549 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
publisher.none.fl_str_mv |
Brazilian Journals Publicações de Periódicos e Editora Ltda. |
dc.source.none.fl_str_mv |
Brazilian Journal of Health Review; Vol. 6 No. 1 (2023); 1649-1660 Brazilian Journal of Health Review; Vol. 6 Núm. 1 (2023); 1649-1660 Brazilian Journal of Health Review; v. 6 n. 1 (2023); 1649-1660 2595-6825 reponame:Brazilian Journal of Health Review instname:Federação das Indústrias do Estado do Paraná (FIEP) instacron:BJRH |
instname_str |
Federação das Indústrias do Estado do Paraná (FIEP) |
instacron_str |
BJRH |
institution |
BJRH |
reponame_str |
Brazilian Journal of Health Review |
collection |
Brazilian Journal of Health Review |
repository.name.fl_str_mv |
Brazilian Journal of Health Review - Federação das Indústrias do Estado do Paraná (FIEP) |
repository.mail.fl_str_mv |
|| brazilianjhr@gmail.com |
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1797240025544392704 |