Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro

Detalhes bibliográficos
Autor(a) principal: Lundberg,Per
Data de Publicação: 2018
Outros Autores: Andersson,Rune, Machado,Elizabeth S., Costa,Tomaz Pinheiro da, Hofer,Cristina Barroso
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500412
Resumo: ABSTRACT Background: Perinatally HIV-infected children are surviving into adulthood, and getting pregnant. There is a scarcity of information on health and pregnancy outcomes in these women. Aim: To evaluate characteristics related to HIV disease and pregnancy outcomes in perinatally infected women, and to compare these women with a group of youth with behaviorally acquired HIV-infection, at a reference hospital in Rio de Janeiro, Brazil. Methods: A cohort study. Epidemiological, clinical, and laboratory data were compared between perinatally (PHIV) and behaviorally HIV-infected (BHIV) pregnant youth with the primary aim to study pregnancy outcomes in the PHIV group and compare with outcomes to BHIV group. Results: Thirty-two pregnancies occurred in PHIV group, and 595 in BHIV group. A total of seven (22%) PHIV women and 64 (11%) BHIV women had a premature delivery (p = 0.04), however, when adjusting for younger age at pregnancy, and antiretroviral therapy initiation in 1st trimester of pregnancy (OR = 18.66, 95%CI = 5.52–63.14), the difference was no longer significant. No cases of mother-to-child HIV transmission (MTCT) were observed in the PHIV group while there was a 2% MTCT rate in BHIV group. Conclusion: Pregnancy among PHIV was as safe as among BHIV. The differences between those groups were probably related to treatment and prolonged care in the first group.
id BSID-1_164685698212287a8ac9c71caabafcf0
oai_identifier_str oai:scielo:S1413-86702018000500412
network_acronym_str BSID-1
network_name_str Brazilian Journal of Infectious Diseases
repository_id_str
spelling Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de JaneiroPerinatal HIVPregnancyMother-to-child transmissionCombined antiretroviral treatmentABSTRACT Background: Perinatally HIV-infected children are surviving into adulthood, and getting pregnant. There is a scarcity of information on health and pregnancy outcomes in these women. Aim: To evaluate characteristics related to HIV disease and pregnancy outcomes in perinatally infected women, and to compare these women with a group of youth with behaviorally acquired HIV-infection, at a reference hospital in Rio de Janeiro, Brazil. Methods: A cohort study. Epidemiological, clinical, and laboratory data were compared between perinatally (PHIV) and behaviorally HIV-infected (BHIV) pregnant youth with the primary aim to study pregnancy outcomes in the PHIV group and compare with outcomes to BHIV group. Results: Thirty-two pregnancies occurred in PHIV group, and 595 in BHIV group. A total of seven (22%) PHIV women and 64 (11%) BHIV women had a premature delivery (p = 0.04), however, when adjusting for younger age at pregnancy, and antiretroviral therapy initiation in 1st trimester of pregnancy (OR = 18.66, 95%CI = 5.52–63.14), the difference was no longer significant. No cases of mother-to-child HIV transmission (MTCT) were observed in the PHIV group while there was a 2% MTCT rate in BHIV group. Conclusion: Pregnancy among PHIV was as safe as among BHIV. The differences between those groups were probably related to treatment and prolonged care in the first group.Brazilian Society of Infectious Diseases2018-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500412Brazilian Journal of Infectious Diseases v.22 n.5 2018reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2018.08.005info:eu-repo/semantics/openAccessLundberg,PerAndersson,RuneMachado,Elizabeth S.Costa,Tomaz Pinheiro daHofer,Cristina Barrosoeng2018-12-14T00:00:00Zoai:scielo:S1413-86702018000500412Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2018-12-14T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro
title Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro
spellingShingle Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro
Lundberg,Per
Perinatal HIV
Pregnancy
Mother-to-child transmission
Combined antiretroviral treatment
title_short Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro
title_full Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro
title_fullStr Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro
title_full_unstemmed Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro
title_sort Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro
author Lundberg,Per
author_facet Lundberg,Per
Andersson,Rune
Machado,Elizabeth S.
Costa,Tomaz Pinheiro da
Hofer,Cristina Barroso
author_role author
author2 Andersson,Rune
Machado,Elizabeth S.
Costa,Tomaz Pinheiro da
Hofer,Cristina Barroso
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lundberg,Per
Andersson,Rune
Machado,Elizabeth S.
Costa,Tomaz Pinheiro da
Hofer,Cristina Barroso
dc.subject.por.fl_str_mv Perinatal HIV
Pregnancy
Mother-to-child transmission
Combined antiretroviral treatment
topic Perinatal HIV
Pregnancy
Mother-to-child transmission
Combined antiretroviral treatment
description ABSTRACT Background: Perinatally HIV-infected children are surviving into adulthood, and getting pregnant. There is a scarcity of information on health and pregnancy outcomes in these women. Aim: To evaluate characteristics related to HIV disease and pregnancy outcomes in perinatally infected women, and to compare these women with a group of youth with behaviorally acquired HIV-infection, at a reference hospital in Rio de Janeiro, Brazil. Methods: A cohort study. Epidemiological, clinical, and laboratory data were compared between perinatally (PHIV) and behaviorally HIV-infected (BHIV) pregnant youth with the primary aim to study pregnancy outcomes in the PHIV group and compare with outcomes to BHIV group. Results: Thirty-two pregnancies occurred in PHIV group, and 595 in BHIV group. A total of seven (22%) PHIV women and 64 (11%) BHIV women had a premature delivery (p = 0.04), however, when adjusting for younger age at pregnancy, and antiretroviral therapy initiation in 1st trimester of pregnancy (OR = 18.66, 95%CI = 5.52–63.14), the difference was no longer significant. No cases of mother-to-child HIV transmission (MTCT) were observed in the PHIV group while there was a 2% MTCT rate in BHIV group. Conclusion: Pregnancy among PHIV was as safe as among BHIV. The differences between those groups were probably related to treatment and prolonged care in the first group.
publishDate 2018
dc.date.none.fl_str_mv 2018-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500412
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000500412
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjid.2018.08.005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.22 n.5 2018
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
_version_ 1754209244592209920