Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1016/j.ijgo.2012.12.021 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/36123 |
Resumo: | Maria I. Gouvea. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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Stoszek, Sonia K.Duarte, GeraldoHance, Laura FreimanisPinto, JorgeGouvea, Maria I.Cohen, Rachel A.Santos, BrenoTeles, ElizabeteSucci, ReginaAlarcon, Jorge O.Read, Jennifer S.NISDI Perinatal/LILAC Study Group2019-10-03T13:38:15Z2019-10-03T13:38:15Z2013STOSZEK, Sonia K. et al. Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009. International Journal of Gynecology and Obstetrics, v. 122, n. 1, p. 37-43, July 2013.0020-7292https://www.arca.fiocruz.br/handle/icict/3612310.1016/j.ijgo.2012.12.0211879-3479Maria I. Gouvea. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-10-03Westat. Health Studies Sector. Rockville, MD, USA.University of São Paulo. Faculty of Medicine of Ribeirão Preto. Ribeirão Preto, SP, Brazil.Westat. Health Studies Sector. Rockville, MD, USA.Universidade Federal de Minas Gerais. Department of Pediatrics. Immunology Division. Belo Horizonte, MG, Brazil.Hospital dos Servidores do Estado - Saúde. Serviço de Doenças Infecciosas e Parasitárias. Rio de Janeiro, RJ, Brasil.Westat. Health Studies Sector. Rockville, MD, USA.Hospital Nossa Senhora da Conceição. Serviço de Infectologia. Porto Alegre, RJ, Brasil.Hospital Femina. Serviço de Infectologia. Porto Alegre, RS, Brasil.Universidade Federal de São Paulo. Escola Paulista de Medicina. São Paulo, SP, Brasil.University of San Marcos. Instituto de Medicina Tropical Daniel Alcides Carrion. Lima, Peru.National Institutes of Health. Department of Health and Human Services. Eunice Kennedy Shriver National Institute of Child Health and Human Development. Pediatric, Adolescent, and Maternal AIDS Branch. Bethesda, MD, USA / National Vaccine Program Office. Department of Health and Human Services. Office of the Secretary. Office of the Assistant Secretary of Health. Washington, DC, USA.Objective — To describe temporal management and outcome trends among HIV-1-infected pregnant women and their infants enrolled in the NISDI Perinatal and LILAC cohorts. Methods — A prospective cohort of 1548 HIV-1-infected pregnant women and their 1481 singleton live-born infants was analyzed. Participants were enrolled at 24 Latin American and Caribbean sites and followed-up for at least 6 months postpartum. Variables were compared by 2-year enrollment periods from September 27, 2002, to June 30, 2009, using logistic and linear regression modeling. Results — Antiretroviral (ARV) use during pregnancy remained high (99.0%). ARVs became increasingly used for treatment (P<0.001). Regimens containing 2 nucleoside reverse transcriptase inhibitors plus a protease inhibitor became more common in later years (P<0.001). The proportion of women with viral loads below 1000 copies/mL at hospital discharge after delivery (HD) increased over time (P=0.0031). Median CD4 lymphocyte counts also rose at HD, from 441 cell/mm3 to 515 cells/mm3 (P<0.05). Elective cesarean deliveries increased from 30.5% to 42.0% (P=0.018). Most infants received ARV prophylaxis (99.7%). Few infants were breastfed (0.5%) or became infected with HIV-1 (1.2%). Conclusion —The results indicate that national HIV-1 treatment and transmission prevention policies are effective among patients with healthcare access in the region.engWileyTrends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAntiretroviralHIV-1Latin AmericaMother-to-child transmissionProphylaxisTreatmentinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36123/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALva_Stoszek_Sonia_etal_INI_2013.pdfva_Stoszek_Sonia_etal_INI_2013.pdfapplication/pdf493950https://www.arca.fiocruz.br/bitstream/icict/36123/2/va_Stoszek_Sonia_etal_INI_2013.pdf2bdc28186f416de6148a1412713e2d8eMD52TEXTva_Stoszek_Sonia_etal_INI_2013.pdf.txtva_Stoszek_Sonia_etal_INI_2013.pdf.txtExtracted texttext/plain42919https://www.arca.fiocruz.br/bitstream/icict/36123/3/va_Stoszek_Sonia_etal_INI_2013.pdf.txtf14591304ba96f43c9483d83120c438eMD53icict/361232021-03-24 16:32:37.224oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:37Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009 |
| title |
Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009 |
| spellingShingle |
Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009 Stoszek, Sonia K. Antiretroviral HIV-1 Latin America Mother-to-child transmission Prophylaxis Treatment |
| title_short |
Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009 |
| title_full |
Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009 |
| title_fullStr |
Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009 |
| title_full_unstemmed |
Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009 |
| title_sort |
Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009 |
| author |
Stoszek, Sonia K. |
| author_facet |
Stoszek, Sonia K. Duarte, Geraldo Hance, Laura Freimanis Pinto, Jorge Gouvea, Maria I. Cohen, Rachel A. Santos, Breno Teles, Elizabete Succi, Regina Alarcon, Jorge O. Read, Jennifer S. NISDI Perinatal/LILAC Study Group |
| author_role |
author |
| author2 |
Duarte, Geraldo Hance, Laura Freimanis Pinto, Jorge Gouvea, Maria I. Cohen, Rachel A. Santos, Breno Teles, Elizabete Succi, Regina Alarcon, Jorge O. Read, Jennifer S. NISDI Perinatal/LILAC Study Group |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Stoszek, Sonia K. Duarte, Geraldo Hance, Laura Freimanis Pinto, Jorge Gouvea, Maria I. Cohen, Rachel A. Santos, Breno Teles, Elizabete Succi, Regina Alarcon, Jorge O. Read, Jennifer S. NISDI Perinatal/LILAC Study Group |
| dc.subject.en.pt_BR.fl_str_mv |
Antiretroviral HIV-1 Latin America Mother-to-child transmission Prophylaxis Treatment |
| topic |
Antiretroviral HIV-1 Latin America Mother-to-child transmission Prophylaxis Treatment |
| description |
Maria I. Gouvea. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento. |
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2013 |
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2013 |
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2019-10-03T13:38:15Z |
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STOSZEK, Sonia K. et al. Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009. International Journal of Gynecology and Obstetrics, v. 122, n. 1, p. 37-43, July 2013. |
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10.1016/j.ijgo.2012.12.021 |
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1879-3479 |
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STOSZEK, Sonia K. et al. Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009. International Journal of Gynecology and Obstetrics, v. 122, n. 1, p. 37-43, July 2013. 0020-7292 10.1016/j.ijgo.2012.12.021 1879-3479 |
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