Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600388 |
Resumo: | ABSTRACT Host immunogenetic setting is involved in the regulation of human papillomavirus (HPV) infection and development of condyloma acuminatum (CA). We investigated the correlation of two common single nucleotide polymorphisms (SNPs) (−607C/A and −137G/C) of IL-18 with the susceptibility of CA in a large Chinese cohort. Out of 408 CA patients analyzed, 300 had HPV infection transmitted through sexual contact (SC) and 108 through non-sexual contact (NSC). In addition, 360 healthy volunteers were enrolled as controls. SNPs at positions −607C/A and −137G/C in IL-18 promoter were analyzed. Comparing CA patients to healthy controls, no dominant relevance was found between the IL-18 promoter −607 C/A or −137G/C polymorphisms and the CA disease either identified genotypically (p > 0.05) or by allelically (p > 0.05). However, the IL-18 promoter −137G/C polymorphism genotype and allele frequencies in the NSC CA group, but not between in the SC group, were significantly higher than in the controls. There was no dominant relevance between IL-18-607C/A polymorphism genotype and allele frequencies among SC, NSC CA patients, and controls. Our study demonstrates that polymorphism −137G/C in IL-18 promoter is significantly correlated with risk of CA in NSC patients. |
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Brazilian Journal of Infectious Diseases |
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Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese populationCondyloma acuminatumHuman papillomavirusCytokineSingle nucleotide polymorphismIL-18ABSTRACT Host immunogenetic setting is involved in the regulation of human papillomavirus (HPV) infection and development of condyloma acuminatum (CA). We investigated the correlation of two common single nucleotide polymorphisms (SNPs) (−607C/A and −137G/C) of IL-18 with the susceptibility of CA in a large Chinese cohort. Out of 408 CA patients analyzed, 300 had HPV infection transmitted through sexual contact (SC) and 108 through non-sexual contact (NSC). In addition, 360 healthy volunteers were enrolled as controls. SNPs at positions −607C/A and −137G/C in IL-18 promoter were analyzed. Comparing CA patients to healthy controls, no dominant relevance was found between the IL-18 promoter −607 C/A or −137G/C polymorphisms and the CA disease either identified genotypically (p > 0.05) or by allelically (p > 0.05). However, the IL-18 promoter −137G/C polymorphism genotype and allele frequencies in the NSC CA group, but not between in the SC group, were significantly higher than in the controls. There was no dominant relevance between IL-18-607C/A polymorphism genotype and allele frequencies among SC, NSC CA patients, and controls. Our study demonstrates that polymorphism −137G/C in IL-18 promoter is significantly correlated with risk of CA in NSC patients.Brazilian Society of Infectious Diseases2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600388Brazilian Journal of Infectious Diseases v.23 n.6 2019reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2019.09.001info:eu-repo/semantics/openAccessWang,ChangyuanWei,LiChu,WeilinYu,HaiyangYu,XinjuanLi,Chunxiaeng2020-02-10T00:00:00Zoai:scielo:S1413-86702019000600388Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2020-02-10T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population |
title |
Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population |
spellingShingle |
Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population Wang,Changyuan Condyloma acuminatum Human papillomavirus Cytokine Single nucleotide polymorphism IL-18 |
title_short |
Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population |
title_full |
Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population |
title_fullStr |
Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population |
title_full_unstemmed |
Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population |
title_sort |
Correlation of interleukin-18 gene polymorphism with the susceptibility of condyloma acuminatum in Chinese population |
author |
Wang,Changyuan |
author_facet |
Wang,Changyuan Wei,Li Chu,Weilin Yu,Haiyang Yu,Xinjuan Li,Chunxia |
author_role |
author |
author2 |
Wei,Li Chu,Weilin Yu,Haiyang Yu,Xinjuan Li,Chunxia |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Wang,Changyuan Wei,Li Chu,Weilin Yu,Haiyang Yu,Xinjuan Li,Chunxia |
dc.subject.por.fl_str_mv |
Condyloma acuminatum Human papillomavirus Cytokine Single nucleotide polymorphism IL-18 |
topic |
Condyloma acuminatum Human papillomavirus Cytokine Single nucleotide polymorphism IL-18 |
description |
ABSTRACT Host immunogenetic setting is involved in the regulation of human papillomavirus (HPV) infection and development of condyloma acuminatum (CA). We investigated the correlation of two common single nucleotide polymorphisms (SNPs) (−607C/A and −137G/C) of IL-18 with the susceptibility of CA in a large Chinese cohort. Out of 408 CA patients analyzed, 300 had HPV infection transmitted through sexual contact (SC) and 108 through non-sexual contact (NSC). In addition, 360 healthy volunteers were enrolled as controls. SNPs at positions −607C/A and −137G/C in IL-18 promoter were analyzed. Comparing CA patients to healthy controls, no dominant relevance was found between the IL-18 promoter −607 C/A or −137G/C polymorphisms and the CA disease either identified genotypically (p > 0.05) or by allelically (p > 0.05). However, the IL-18 promoter −137G/C polymorphism genotype and allele frequencies in the NSC CA group, but not between in the SC group, were significantly higher than in the controls. There was no dominant relevance between IL-18-607C/A polymorphism genotype and allele frequencies among SC, NSC CA patients, and controls. Our study demonstrates that polymorphism −137G/C in IL-18 promoter is significantly correlated with risk of CA in NSC patients. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600388 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600388 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.bjid.2019.09.001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.23 n.6 2019 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209244704407552 |