Apoptosis and progression of hepatic fibrosis in hepatitis C patients

Detalhes bibliográficos
Autor(a) principal: Schinoni,Maria Isabel
Data de Publicação: 2006
Outros Autores: Paraná,Raymundo, Cavalcante,Daniel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200009
Resumo: Hepatitis C is a worldwide endemic disease, affecting roughly 200 million people. It has a variable prognosis, depending on the progression to fibrosis. During the last five years, the importance of apoptosis for the pathogenesis of various diseases, including hepatitis, has been recognized. It has been suggested that an increase in T cell-apoptosis during a hepatitis C virus infection is the cause of impaired regulation of the immune cellular response, helping to maintain infection. Thus, the interest in discovering the probable mechanisms by which the hepatitis C virus perpetuates in the liver, and to determine the conditions that predispose for progression of this disease, makes investigation of apoptosis in hepatic injury of great interest. We have made an overview of the various mechanisms by which the cell, more specifically the hepatic cell, is affected by apoptosis, and how it interacts with the hepatitis C virus and the immune system.
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spelling Apoptosis and progression of hepatic fibrosis in hepatitis C patientsApoptosishepatitis Cliver fibrosisHepatitis C is a worldwide endemic disease, affecting roughly 200 million people. It has a variable prognosis, depending on the progression to fibrosis. During the last five years, the importance of apoptosis for the pathogenesis of various diseases, including hepatitis, has been recognized. It has been suggested that an increase in T cell-apoptosis during a hepatitis C virus infection is the cause of impaired regulation of the immune cellular response, helping to maintain infection. Thus, the interest in discovering the probable mechanisms by which the hepatitis C virus perpetuates in the liver, and to determine the conditions that predispose for progression of this disease, makes investigation of apoptosis in hepatic injury of great interest. We have made an overview of the various mechanisms by which the cell, more specifically the hepatic cell, is affected by apoptosis, and how it interacts with the hepatitis C virus and the immune system.Brazilian Society of Infectious Diseases2006-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200009Brazilian Journal of Infectious Diseases v.10 n.2 2006reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702006000200009info:eu-repo/semantics/openAccessSchinoni,Maria IsabelParaná,RaymundoCavalcante,Danieleng2006-07-21T00:00:00Zoai:scielo:S1413-86702006000200009Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2006-07-21T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Apoptosis and progression of hepatic fibrosis in hepatitis C patients
title Apoptosis and progression of hepatic fibrosis in hepatitis C patients
spellingShingle Apoptosis and progression of hepatic fibrosis in hepatitis C patients
Schinoni,Maria Isabel
Apoptosis
hepatitis C
liver fibrosis
title_short Apoptosis and progression of hepatic fibrosis in hepatitis C patients
title_full Apoptosis and progression of hepatic fibrosis in hepatitis C patients
title_fullStr Apoptosis and progression of hepatic fibrosis in hepatitis C patients
title_full_unstemmed Apoptosis and progression of hepatic fibrosis in hepatitis C patients
title_sort Apoptosis and progression of hepatic fibrosis in hepatitis C patients
author Schinoni,Maria Isabel
author_facet Schinoni,Maria Isabel
Paraná,Raymundo
Cavalcante,Daniel
author_role author
author2 Paraná,Raymundo
Cavalcante,Daniel
author2_role author
author
dc.contributor.author.fl_str_mv Schinoni,Maria Isabel
Paraná,Raymundo
Cavalcante,Daniel
dc.subject.por.fl_str_mv Apoptosis
hepatitis C
liver fibrosis
topic Apoptosis
hepatitis C
liver fibrosis
description Hepatitis C is a worldwide endemic disease, affecting roughly 200 million people. It has a variable prognosis, depending on the progression to fibrosis. During the last five years, the importance of apoptosis for the pathogenesis of various diseases, including hepatitis, has been recognized. It has been suggested that an increase in T cell-apoptosis during a hepatitis C virus infection is the cause of impaired regulation of the immune cellular response, helping to maintain infection. Thus, the interest in discovering the probable mechanisms by which the hepatitis C virus perpetuates in the liver, and to determine the conditions that predispose for progression of this disease, makes investigation of apoptosis in hepatic injury of great interest. We have made an overview of the various mechanisms by which the cell, more specifically the hepatic cell, is affected by apoptosis, and how it interacts with the hepatitis C virus and the immune system.
publishDate 2006
dc.date.none.fl_str_mv 2006-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-86702006000200009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.10 n.2 2006
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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