Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection
Autor(a) principal: | |
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Data de Publicação: | 2002 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S1413-86702002000500002 http://repositorio.unifesp.br/handle/11600/1530 |
Resumo: | There is increasing interest in the identification of factors associated with liver disease progression in patients infected with hepatitis C virus (HCV). We assessed host-related factors associated with a histologically advanced stage of this disease and determined the rate of liver fibrosis progression in HCV-infected patients. We included patients submitted to liver biopsy, who were anti-HCV and HCV RNA positive, who showed a parenteral risk factor (blood transfusion or intravenous drug use), and who gave information about alcohol consumption.Patients were divided into two groups for analysis: group 1 - grades 0 to 2; group 2 - grades 3 to 4. The groups were compared in terms of sex, age at the time of infection, estimated duration of infection and alcoholism. The rate of fibrosis progression (index of fibrosis) was determined based on the relationship between disease stage and duration of infection (years). Logistic regression analysis revealed that age at the time of infection (P<0.01; 95% CI 1.06-1.22) and the duration of infection (P<0.01; 95% CI 1.06-1.32) were independently associated with a more advanced stage of hepatitis C. The median index of fibrosis was 0.14 for the group as a whole. A significant difference in the index of fibrosis was observed between patients aged < 40 years at infection (median = 0.11) and patients aged> or =40 years (median = 0.47). The main factors associated with a more rapid fibrosis progression were age at the time of infection and the estimated duration of infection. Patients who acquired HCV after 40 years of age showed a higher rate of fibrosis progression. |
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Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infectionHepatitis C virusliver fibrosispatientsThere is increasing interest in the identification of factors associated with liver disease progression in patients infected with hepatitis C virus (HCV). We assessed host-related factors associated with a histologically advanced stage of this disease and determined the rate of liver fibrosis progression in HCV-infected patients. We included patients submitted to liver biopsy, who were anti-HCV and HCV RNA positive, who showed a parenteral risk factor (blood transfusion or intravenous drug use), and who gave information about alcohol consumption.Patients were divided into two groups for analysis: group 1 - grades 0 to 2; group 2 - grades 3 to 4. The groups were compared in terms of sex, age at the time of infection, estimated duration of infection and alcoholism. The rate of fibrosis progression (index of fibrosis) was determined based on the relationship between disease stage and duration of infection (years). Logistic regression analysis revealed that age at the time of infection (P<0.01; 95% CI 1.06-1.22) and the duration of infection (P<0.01; 95% CI 1.06-1.32) were independently associated with a more advanced stage of hepatitis C. The median index of fibrosis was 0.14 for the group as a whole. A significant difference in the index of fibrosis was observed between patients aged < 40 years at infection (median = 0.11) and patients aged> or =40 years (median = 0.47). The main factors associated with a more rapid fibrosis progression were age at the time of infection and the estimated duration of infection. Patients who acquired HCV after 40 years of age showed a higher rate of fibrosis progression.Universidade Federal de São Paulo (UNIFESP) Department of GastroenterologyUNIFESP, Department of GastroenterologySciELOBrazilian Society of Infectious DiseasesUniversidade Federal de São Paulo (UNIFESP)Costa, Luciano Bello [UNIFESP]Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]Perez, Renata de Mello [UNIFESP]Ferreira, Adalgisa de Souza Paiva [UNIFESP]Matos, Carla Adriana Loureiro de [UNIFESP]Lanzoni, Valeria Pereira [UNIFESP]Silva, Antonio Eduardo Benedito [UNIFESP]2015-06-14T13:29:48Z2015-06-14T13:29:48Z2002-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion219-224application/pdfhttp://dx.doi.org/10.1590/S1413-86702002000500002Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 6, n. 5, p. 219-224, 2002.10.1590/S1413-86702002000500002S1413-86702002000500002.pdf1413-8670S1413-86702002000500002http://repositorio.unifesp.br/handle/11600/1530engBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T23:46:53Zoai:repositorio.unifesp.br/:11600/1530Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T23:46:53Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection |
title |
Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection |
spellingShingle |
Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection Costa, Luciano Bello [UNIFESP] Hepatitis C virus liver fibrosis patients |
title_short |
Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection |
title_full |
Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection |
title_fullStr |
Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection |
title_full_unstemmed |
Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection |
title_sort |
Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection |
author |
Costa, Luciano Bello [UNIFESP] |
author_facet |
Costa, Luciano Bello [UNIFESP] Ferraz, Maria Lucia Cardoso Gomes [UNIFESP] Perez, Renata de Mello [UNIFESP] Ferreira, Adalgisa de Souza Paiva [UNIFESP] Matos, Carla Adriana Loureiro de [UNIFESP] Lanzoni, Valeria Pereira [UNIFESP] Silva, Antonio Eduardo Benedito [UNIFESP] |
author_role |
author |
author2 |
Ferraz, Maria Lucia Cardoso Gomes [UNIFESP] Perez, Renata de Mello [UNIFESP] Ferreira, Adalgisa de Souza Paiva [UNIFESP] Matos, Carla Adriana Loureiro de [UNIFESP] Lanzoni, Valeria Pereira [UNIFESP] Silva, Antonio Eduardo Benedito [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Costa, Luciano Bello [UNIFESP] Ferraz, Maria Lucia Cardoso Gomes [UNIFESP] Perez, Renata de Mello [UNIFESP] Ferreira, Adalgisa de Souza Paiva [UNIFESP] Matos, Carla Adriana Loureiro de [UNIFESP] Lanzoni, Valeria Pereira [UNIFESP] Silva, Antonio Eduardo Benedito [UNIFESP] |
dc.subject.por.fl_str_mv |
Hepatitis C virus liver fibrosis patients |
topic |
Hepatitis C virus liver fibrosis patients |
description |
There is increasing interest in the identification of factors associated with liver disease progression in patients infected with hepatitis C virus (HCV). We assessed host-related factors associated with a histologically advanced stage of this disease and determined the rate of liver fibrosis progression in HCV-infected patients. We included patients submitted to liver biopsy, who were anti-HCV and HCV RNA positive, who showed a parenteral risk factor (blood transfusion or intravenous drug use), and who gave information about alcohol consumption.Patients were divided into two groups for analysis: group 1 - grades 0 to 2; group 2 - grades 3 to 4. The groups were compared in terms of sex, age at the time of infection, estimated duration of infection and alcoholism. The rate of fibrosis progression (index of fibrosis) was determined based on the relationship between disease stage and duration of infection (years). Logistic regression analysis revealed that age at the time of infection (P<0.01; 95% CI 1.06-1.22) and the duration of infection (P<0.01; 95% CI 1.06-1.32) were independently associated with a more advanced stage of hepatitis C. The median index of fibrosis was 0.14 for the group as a whole. A significant difference in the index of fibrosis was observed between patients aged < 40 years at infection (median = 0.11) and patients aged> or =40 years (median = 0.47). The main factors associated with a more rapid fibrosis progression were age at the time of infection and the estimated duration of infection. Patients who acquired HCV after 40 years of age showed a higher rate of fibrosis progression. |
publishDate |
2002 |
dc.date.none.fl_str_mv |
2002-10-01 2015-06-14T13:29:48Z 2015-06-14T13:29:48Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1413-86702002000500002 Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 6, n. 5, p. 219-224, 2002. 10.1590/S1413-86702002000500002 S1413-86702002000500002.pdf 1413-8670 S1413-86702002000500002 http://repositorio.unifesp.br/handle/11600/1530 |
url |
http://dx.doi.org/10.1590/S1413-86702002000500002 http://repositorio.unifesp.br/handle/11600/1530 |
identifier_str_mv |
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 6, n. 5, p. 219-224, 2002. 10.1590/S1413-86702002000500002 S1413-86702002000500002.pdf 1413-8670 S1413-86702002000500002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Infectious Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
219-224 application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268398257831936 |