Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection

Detalhes bibliográficos
Autor(a) principal: Costa, Luciano Bello [UNIFESP]
Data de Publicação: 2002
Outros Autores: Ferraz, Maria Lucia Cardoso Gomes [UNIFESP], Perez, Renata de Mello [UNIFESP], Ferreira, Adalgisa de Souza Paiva [UNIFESP], Matos, Carla Adriana Loureiro de [UNIFESP], Lanzoni, Valeria Pereira [UNIFESP], Silva, Antonio Eduardo Benedito [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1413-86702002000500002
http://repositorio.unifesp.br/handle/11600/1530
Resumo: There is increasing interest in the identification of factors associated with liver disease progression in patients infected with hepatitis C virus (HCV). We assessed host-related factors associated with a histologically advanced stage of this disease and determined the rate of liver fibrosis progression in HCV-infected patients. We included patients submitted to liver biopsy, who were anti-HCV and HCV RNA positive, who showed a parenteral risk factor (blood transfusion or intravenous drug use), and who gave information about alcohol consumption.Patients were divided into two groups for analysis: group 1 - grades 0 to 2; group 2 - grades 3 to 4. The groups were compared in terms of sex, age at the time of infection, estimated duration of infection and alcoholism. The rate of fibrosis progression (index of fibrosis) was determined based on the relationship between disease stage and duration of infection (years). Logistic regression analysis revealed that age at the time of infection (P<0.01; 95% CI 1.06-1.22) and the duration of infection (P<0.01; 95% CI 1.06-1.32) were independently associated with a more advanced stage of hepatitis C. The median index of fibrosis was 0.14 for the group as a whole. A significant difference in the index of fibrosis was observed between patients aged < 40 years at infection (median = 0.11) and patients aged> or =40 years (median = 0.47). The main factors associated with a more rapid fibrosis progression were age at the time of infection and the estimated duration of infection. Patients who acquired HCV after 40 years of age showed a higher rate of fibrosis progression.
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spelling Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infectionHepatitis C virusliver fibrosispatientsThere is increasing interest in the identification of factors associated with liver disease progression in patients infected with hepatitis C virus (HCV). We assessed host-related factors associated with a histologically advanced stage of this disease and determined the rate of liver fibrosis progression in HCV-infected patients. We included patients submitted to liver biopsy, who were anti-HCV and HCV RNA positive, who showed a parenteral risk factor (blood transfusion or intravenous drug use), and who gave information about alcohol consumption.Patients were divided into two groups for analysis: group 1 - grades 0 to 2; group 2 - grades 3 to 4. The groups were compared in terms of sex, age at the time of infection, estimated duration of infection and alcoholism. The rate of fibrosis progression (index of fibrosis) was determined based on the relationship between disease stage and duration of infection (years). Logistic regression analysis revealed that age at the time of infection (P<0.01; 95% CI 1.06-1.22) and the duration of infection (P<0.01; 95% CI 1.06-1.32) were independently associated with a more advanced stage of hepatitis C. The median index of fibrosis was 0.14 for the group as a whole. A significant difference in the index of fibrosis was observed between patients aged < 40 years at infection (median = 0.11) and patients aged> or =40 years (median = 0.47). The main factors associated with a more rapid fibrosis progression were age at the time of infection and the estimated duration of infection. Patients who acquired HCV after 40 years of age showed a higher rate of fibrosis progression.Universidade Federal de São Paulo (UNIFESP) Department of GastroenterologyUNIFESP, Department of GastroenterologySciELOBrazilian Society of Infectious DiseasesUniversidade Federal de São Paulo (UNIFESP)Costa, Luciano Bello [UNIFESP]Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]Perez, Renata de Mello [UNIFESP]Ferreira, Adalgisa de Souza Paiva [UNIFESP]Matos, Carla Adriana Loureiro de [UNIFESP]Lanzoni, Valeria Pereira [UNIFESP]Silva, Antonio Eduardo Benedito [UNIFESP]2015-06-14T13:29:48Z2015-06-14T13:29:48Z2002-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion219-224application/pdfhttp://dx.doi.org/10.1590/S1413-86702002000500002Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 6, n. 5, p. 219-224, 2002.10.1590/S1413-86702002000500002S1413-86702002000500002.pdf1413-8670S1413-86702002000500002http://repositorio.unifesp.br/handle/11600/1530engBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T23:46:53Zoai:repositorio.unifesp.br/:11600/1530Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T23:46:53Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection
title Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection
spellingShingle Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection
Costa, Luciano Bello [UNIFESP]
Hepatitis C virus
liver fibrosis
patients
title_short Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection
title_full Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection
title_fullStr Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection
title_full_unstemmed Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection
title_sort Effect of host-related factors on the intensity of liver fibrosis in patients with chronic hepatitis C virus infection
author Costa, Luciano Bello [UNIFESP]
author_facet Costa, Luciano Bello [UNIFESP]
Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Perez, Renata de Mello [UNIFESP]
Ferreira, Adalgisa de Souza Paiva [UNIFESP]
Matos, Carla Adriana Loureiro de [UNIFESP]
Lanzoni, Valeria Pereira [UNIFESP]
Silva, Antonio Eduardo Benedito [UNIFESP]
author_role author
author2 Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Perez, Renata de Mello [UNIFESP]
Ferreira, Adalgisa de Souza Paiva [UNIFESP]
Matos, Carla Adriana Loureiro de [UNIFESP]
Lanzoni, Valeria Pereira [UNIFESP]
Silva, Antonio Eduardo Benedito [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Costa, Luciano Bello [UNIFESP]
Ferraz, Maria Lucia Cardoso Gomes [UNIFESP]
Perez, Renata de Mello [UNIFESP]
Ferreira, Adalgisa de Souza Paiva [UNIFESP]
Matos, Carla Adriana Loureiro de [UNIFESP]
Lanzoni, Valeria Pereira [UNIFESP]
Silva, Antonio Eduardo Benedito [UNIFESP]
dc.subject.por.fl_str_mv Hepatitis C virus
liver fibrosis
patients
topic Hepatitis C virus
liver fibrosis
patients
description There is increasing interest in the identification of factors associated with liver disease progression in patients infected with hepatitis C virus (HCV). We assessed host-related factors associated with a histologically advanced stage of this disease and determined the rate of liver fibrosis progression in HCV-infected patients. We included patients submitted to liver biopsy, who were anti-HCV and HCV RNA positive, who showed a parenteral risk factor (blood transfusion or intravenous drug use), and who gave information about alcohol consumption.Patients were divided into two groups for analysis: group 1 - grades 0 to 2; group 2 - grades 3 to 4. The groups were compared in terms of sex, age at the time of infection, estimated duration of infection and alcoholism. The rate of fibrosis progression (index of fibrosis) was determined based on the relationship between disease stage and duration of infection (years). Logistic regression analysis revealed that age at the time of infection (P<0.01; 95% CI 1.06-1.22) and the duration of infection (P<0.01; 95% CI 1.06-1.32) were independently associated with a more advanced stage of hepatitis C. The median index of fibrosis was 0.14 for the group as a whole. A significant difference in the index of fibrosis was observed between patients aged < 40 years at infection (median = 0.11) and patients aged> or =40 years (median = 0.47). The main factors associated with a more rapid fibrosis progression were age at the time of infection and the estimated duration of infection. Patients who acquired HCV after 40 years of age showed a higher rate of fibrosis progression.
publishDate 2002
dc.date.none.fl_str_mv 2002-10-01
2015-06-14T13:29:48Z
2015-06-14T13:29:48Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1413-86702002000500002
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 6, n. 5, p. 219-224, 2002.
10.1590/S1413-86702002000500002
S1413-86702002000500002.pdf
1413-8670
S1413-86702002000500002
http://repositorio.unifesp.br/handle/11600/1530
url http://dx.doi.org/10.1590/S1413-86702002000500002
http://repositorio.unifesp.br/handle/11600/1530
identifier_str_mv Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 6, n. 5, p. 219-224, 2002.
10.1590/S1413-86702002000500002
S1413-86702002000500002.pdf
1413-8670
S1413-86702002000500002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Infectious Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 219-224
application/pdf
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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