Gamma variant vertically transmitted from a mild symptomatic pregnant woman associated with fatal neonatal COVID

• Autor(a) principal: Gonçalves-Ferri,Walusa Assad
• Data de Publicação: 2022
• Outros Autores: Carvalheiro,Cristina Galdonyi, Mussi-Pinhata,Marisa Marcia, Cavasin,Bruna Pinto Dias, Fonseca,Benedito Antonio Lopes da
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: Brazilian Journal of Infectious Diseases
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702022000400400
• topic: Sars-CoV-2 variant; Vertical transmission; Covid 19; Preterm infant

ABSTRACT Herein we describe a mild symptomatic real-time reverse transcriptase- polymerase chain reaction-confirmed coronavirus 2 (SARS-CoV-2) infection in a pregnant woman who gave birth to a preterm infant, 32 weeks gestational age. The neonate was immediately isolated after delivery and developed severe respiratory disease that progressed to multisystem inflammatory syndrome and death on the seventh day of life. Genome sequencing detected the P.1 (gamma) variant in samples obtained at hospital admission (mother) and on the first (10h) and 13th days of life (neonate). Complete homology (mother’s and newborn’s sequences) confirmed vertical transmission. To our knowledge, this is the first report of vertically-transmitted SARS-CoV-2 P.1 (gamma) variant in a mild symptomatic infection in pregnancy associated with fatal COVID in a neonate.