Progress towards meningitis prevention in the conjugate vaccines era

Detalhes bibliográficos
Autor(a) principal: Laval,Cristina Aparecida Borges
Data de Publicação: 2003
Outros Autores: Pimenta,Fabiana Cristina, Andrade,João Guimarães de, Andrade,Soraya S., Andrade,Ana Lucia S. S. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500006
Resumo: Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.
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spelling Progress towards meningitis prevention in the conjugate vaccines eraConjugate vaccinesHib conjugate vaccinepneumococcal conjugate vaccinemeningococcal conjugate vaccineimpact of Hib conjugate vaccineAcute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.Brazilian Society of Infectious Diseases2003-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500006Brazilian Journal of Infectious Diseases v.7 n.5 2003reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702003000500006info:eu-repo/semantics/openAccessLaval,Cristina Aparecida BorgesPimenta,Fabiana CristinaAndrade,João Guimarães deAndrade,Soraya S.Andrade,Ana Lucia S. S. deeng2004-01-22T00:00:00Zoai:scielo:S1413-86702003000500006Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2004-01-22T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Progress towards meningitis prevention in the conjugate vaccines era
title Progress towards meningitis prevention in the conjugate vaccines era
spellingShingle Progress towards meningitis prevention in the conjugate vaccines era
Laval,Cristina Aparecida Borges
Conjugate vaccines
Hib conjugate vaccine
pneumococcal conjugate vaccine
meningococcal conjugate vaccine
impact of Hib conjugate vaccine
title_short Progress towards meningitis prevention in the conjugate vaccines era
title_full Progress towards meningitis prevention in the conjugate vaccines era
title_fullStr Progress towards meningitis prevention in the conjugate vaccines era
title_full_unstemmed Progress towards meningitis prevention in the conjugate vaccines era
title_sort Progress towards meningitis prevention in the conjugate vaccines era
author Laval,Cristina Aparecida Borges
author_facet Laval,Cristina Aparecida Borges
Pimenta,Fabiana Cristina
Andrade,João Guimarães de
Andrade,Soraya S.
Andrade,Ana Lucia S. S. de
author_role author
author2 Pimenta,Fabiana Cristina
Andrade,João Guimarães de
Andrade,Soraya S.
Andrade,Ana Lucia S. S. de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Laval,Cristina Aparecida Borges
Pimenta,Fabiana Cristina
Andrade,João Guimarães de
Andrade,Soraya S.
Andrade,Ana Lucia S. S. de
dc.subject.por.fl_str_mv Conjugate vaccines
Hib conjugate vaccine
pneumococcal conjugate vaccine
meningococcal conjugate vaccine
impact of Hib conjugate vaccine
topic Conjugate vaccines
Hib conjugate vaccine
pneumococcal conjugate vaccine
meningococcal conjugate vaccine
impact of Hib conjugate vaccine
description Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.
publishDate 2003
dc.date.none.fl_str_mv 2003-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1413-86702003000500006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.7 n.5 2003
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
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