Progress towards meningitis prevention in the conjugate vaccines era
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500006 |
Resumo: | Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions. |
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Brazilian Journal of Infectious Diseases |
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Progress towards meningitis prevention in the conjugate vaccines eraConjugate vaccinesHib conjugate vaccinepneumococcal conjugate vaccinemeningococcal conjugate vaccineimpact of Hib conjugate vaccineAcute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.Brazilian Society of Infectious Diseases2003-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500006Brazilian Journal of Infectious Diseases v.7 n.5 2003reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702003000500006info:eu-repo/semantics/openAccessLaval,Cristina Aparecida BorgesPimenta,Fabiana CristinaAndrade,João Guimarães deAndrade,Soraya S.Andrade,Ana Lucia S. S. deeng2004-01-22T00:00:00Zoai:scielo:S1413-86702003000500006Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2004-01-22T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Progress towards meningitis prevention in the conjugate vaccines era |
title |
Progress towards meningitis prevention in the conjugate vaccines era |
spellingShingle |
Progress towards meningitis prevention in the conjugate vaccines era Laval,Cristina Aparecida Borges Conjugate vaccines Hib conjugate vaccine pneumococcal conjugate vaccine meningococcal conjugate vaccine impact of Hib conjugate vaccine |
title_short |
Progress towards meningitis prevention in the conjugate vaccines era |
title_full |
Progress towards meningitis prevention in the conjugate vaccines era |
title_fullStr |
Progress towards meningitis prevention in the conjugate vaccines era |
title_full_unstemmed |
Progress towards meningitis prevention in the conjugate vaccines era |
title_sort |
Progress towards meningitis prevention in the conjugate vaccines era |
author |
Laval,Cristina Aparecida Borges |
author_facet |
Laval,Cristina Aparecida Borges Pimenta,Fabiana Cristina Andrade,João Guimarães de Andrade,Soraya S. Andrade,Ana Lucia S. S. de |
author_role |
author |
author2 |
Pimenta,Fabiana Cristina Andrade,João Guimarães de Andrade,Soraya S. Andrade,Ana Lucia S. S. de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Laval,Cristina Aparecida Borges Pimenta,Fabiana Cristina Andrade,João Guimarães de Andrade,Soraya S. Andrade,Ana Lucia S. S. de |
dc.subject.por.fl_str_mv |
Conjugate vaccines Hib conjugate vaccine pneumococcal conjugate vaccine meningococcal conjugate vaccine impact of Hib conjugate vaccine |
topic |
Conjugate vaccines Hib conjugate vaccine pneumococcal conjugate vaccine meningococcal conjugate vaccine impact of Hib conjugate vaccine |
description |
Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-10-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-86702003000500006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.7 n.5 2003 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209238637346816 |