Progress towards meningitis prevention in the conjugate vaccines era

Detalhes bibliográficos
Autor(a) principal: Laval, Cristina Aparecida Borges
Data de Publicação: 2003
Outros Autores: Pimenta, Fabiana Cristina, Andrade, João Guimarães de, Andrade, Soraya Sgambatti [UNIFESP], Andrade, Ana Lucia S. S. de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1413-86702003000500006
http://repositorio.unifesp.br/handle/11600/1865
Resumo: Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.
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spelling Progress towards meningitis prevention in the conjugate vaccines eraConjugate vaccinesHib conjugate vaccinepneumococcal conjugate vaccinemeningococcal conjugate vaccineimpact of Hib conjugate vaccineAcute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.Federal University of Goiás Institute of Tropical Pathology and Public HealthFederal University of São Paulo Division of Infectious DiseasesUNIFESP, Division of Infectious DiseasesSciELOConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Brazilian Society of Infectious DiseasesFederal University of Goiás Institute of Tropical Pathology and Public HealthUniversidade Federal de São Paulo (UNIFESP)Laval, Cristina Aparecida BorgesPimenta, Fabiana CristinaAndrade, João Guimarães deAndrade, Soraya Sgambatti [UNIFESP]Andrade, Ana Lucia S. S. de2015-06-14T13:30:09Z2015-06-14T13:30:09Z2003-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion315-324application/pdfhttp://dx.doi.org/10.1590/S1413-86702003000500006Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 315-324, 2003.10.1590/S1413-86702003000500006S1413-86702003000500006.pdf1413-8670S1413-86702003000500006http://repositorio.unifesp.br/handle/11600/1865engBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T23:47:18Zoai:repositorio.unifesp.br/:11600/1865Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T23:47:18Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Progress towards meningitis prevention in the conjugate vaccines era
title Progress towards meningitis prevention in the conjugate vaccines era
spellingShingle Progress towards meningitis prevention in the conjugate vaccines era
Laval, Cristina Aparecida Borges
Conjugate vaccines
Hib conjugate vaccine
pneumococcal conjugate vaccine
meningococcal conjugate vaccine
impact of Hib conjugate vaccine
title_short Progress towards meningitis prevention in the conjugate vaccines era
title_full Progress towards meningitis prevention in the conjugate vaccines era
title_fullStr Progress towards meningitis prevention in the conjugate vaccines era
title_full_unstemmed Progress towards meningitis prevention in the conjugate vaccines era
title_sort Progress towards meningitis prevention in the conjugate vaccines era
author Laval, Cristina Aparecida Borges
author_facet Laval, Cristina Aparecida Borges
Pimenta, Fabiana Cristina
Andrade, João Guimarães de
Andrade, Soraya Sgambatti [UNIFESP]
Andrade, Ana Lucia S. S. de
author_role author
author2 Pimenta, Fabiana Cristina
Andrade, João Guimarães de
Andrade, Soraya Sgambatti [UNIFESP]
Andrade, Ana Lucia S. S. de
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Federal University of Goiás Institute of Tropical Pathology and Public Health
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Laval, Cristina Aparecida Borges
Pimenta, Fabiana Cristina
Andrade, João Guimarães de
Andrade, Soraya Sgambatti [UNIFESP]
Andrade, Ana Lucia S. S. de
dc.subject.por.fl_str_mv Conjugate vaccines
Hib conjugate vaccine
pneumococcal conjugate vaccine
meningococcal conjugate vaccine
impact of Hib conjugate vaccine
topic Conjugate vaccines
Hib conjugate vaccine
pneumococcal conjugate vaccine
meningococcal conjugate vaccine
impact of Hib conjugate vaccine
description Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.
publishDate 2003
dc.date.none.fl_str_mv 2003-10-01
2015-06-14T13:30:09Z
2015-06-14T13:30:09Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1413-86702003000500006
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 315-324, 2003.
10.1590/S1413-86702003000500006
S1413-86702003000500006.pdf
1413-8670
S1413-86702003000500006
http://repositorio.unifesp.br/handle/11600/1865
url http://dx.doi.org/10.1590/S1413-86702003000500006
http://repositorio.unifesp.br/handle/11600/1865
identifier_str_mv Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 315-324, 2003.
10.1590/S1413-86702003000500006
S1413-86702003000500006.pdf
1413-8670
S1413-86702003000500006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Infectious Diseases
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 315-324
application/pdf
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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