Progress towards meningitis prevention in the conjugate vaccines era
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S1413-86702003000500006 http://repositorio.unifesp.br/handle/11600/1865 |
Resumo: | Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions. |
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Repositório Institucional da UNIFESP |
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Progress towards meningitis prevention in the conjugate vaccines eraConjugate vaccinesHib conjugate vaccinepneumococcal conjugate vaccinemeningococcal conjugate vaccineimpact of Hib conjugate vaccineAcute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions.Federal University of Goiás Institute of Tropical Pathology and Public HealthFederal University of São Paulo Division of Infectious DiseasesUNIFESP, Division of Infectious DiseasesSciELOConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Brazilian Society of Infectious DiseasesFederal University of Goiás Institute of Tropical Pathology and Public HealthUniversidade Federal de São Paulo (UNIFESP)Laval, Cristina Aparecida BorgesPimenta, Fabiana CristinaAndrade, João Guimarães deAndrade, Soraya Sgambatti [UNIFESP]Andrade, Ana Lucia S. S. de2015-06-14T13:30:09Z2015-06-14T13:30:09Z2003-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion315-324application/pdfhttp://dx.doi.org/10.1590/S1413-86702003000500006Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 315-324, 2003.10.1590/S1413-86702003000500006S1413-86702003000500006.pdf1413-8670S1413-86702003000500006http://repositorio.unifesp.br/handle/11600/1865engBrazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T23:47:18Zoai:repositorio.unifesp.br/:11600/1865Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T23:47:18Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Progress towards meningitis prevention in the conjugate vaccines era |
title |
Progress towards meningitis prevention in the conjugate vaccines era |
spellingShingle |
Progress towards meningitis prevention in the conjugate vaccines era Laval, Cristina Aparecida Borges Conjugate vaccines Hib conjugate vaccine pneumococcal conjugate vaccine meningococcal conjugate vaccine impact of Hib conjugate vaccine |
title_short |
Progress towards meningitis prevention in the conjugate vaccines era |
title_full |
Progress towards meningitis prevention in the conjugate vaccines era |
title_fullStr |
Progress towards meningitis prevention in the conjugate vaccines era |
title_full_unstemmed |
Progress towards meningitis prevention in the conjugate vaccines era |
title_sort |
Progress towards meningitis prevention in the conjugate vaccines era |
author |
Laval, Cristina Aparecida Borges |
author_facet |
Laval, Cristina Aparecida Borges Pimenta, Fabiana Cristina Andrade, João Guimarães de Andrade, Soraya Sgambatti [UNIFESP] Andrade, Ana Lucia S. S. de |
author_role |
author |
author2 |
Pimenta, Fabiana Cristina Andrade, João Guimarães de Andrade, Soraya Sgambatti [UNIFESP] Andrade, Ana Lucia S. S. de |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Federal University of Goiás Institute of Tropical Pathology and Public Health Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Laval, Cristina Aparecida Borges Pimenta, Fabiana Cristina Andrade, João Guimarães de Andrade, Soraya Sgambatti [UNIFESP] Andrade, Ana Lucia S. S. de |
dc.subject.por.fl_str_mv |
Conjugate vaccines Hib conjugate vaccine pneumococcal conjugate vaccine meningococcal conjugate vaccine impact of Hib conjugate vaccine |
topic |
Conjugate vaccines Hib conjugate vaccine pneumococcal conjugate vaccine meningococcal conjugate vaccine impact of Hib conjugate vaccine |
description |
Acute bacterial meningitis is an important cause of morbidity and mortality among children less than five years old. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis are the most important agents of bacterial meningitis in developing countries. The development of the conjugate vaccines in the beginning of the 90's, especially type b H. influenzae (Hib), and more recently the heptavalent pneumococcal and the serogroup C meningococcal vaccines, have contributed directly to changes in the epidemiological profile of these invasive diseases (direct effect) and of their carriage status (indirect effect). We review the impact of the Hib conjugate vaccine in Latin American countries, where this vaccine has been implemented, and the potential of pneumococcal and meningococcal conjugate vaccines for the reduction of meningitis worldwide. We also address constraints for the development and delivery of these vaccines and review new candidate state-of-the-art vaccines. The greatest challenge, undoubtedly, is to implement these vaccines worldwide, especially in the developing regions. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-10-01 2015-06-14T13:30:09Z 2015-06-14T13:30:09Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1413-86702003000500006 Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 315-324, 2003. 10.1590/S1413-86702003000500006 S1413-86702003000500006.pdf 1413-8670 S1413-86702003000500006 http://repositorio.unifesp.br/handle/11600/1865 |
url |
http://dx.doi.org/10.1590/S1413-86702003000500006 http://repositorio.unifesp.br/handle/11600/1865 |
identifier_str_mv |
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 7, n. 5, p. 315-324, 2003. 10.1590/S1413-86702003000500006 S1413-86702003000500006.pdf 1413-8670 S1413-86702003000500006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Infectious Diseases |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
315-324 application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268268177784832 |