Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil
Main Author: | |
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Publication Date: | 2009 |
Other Authors: | , , , , |
Format: | Article |
Language: | eng |
Source: | Brazilian Journal of Infectious Diseases |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400004 |
Summary: | HCV infected patients frequently ask their physician about the risk of transmission to their partners. Although it is easy to answer that the risk does exist, it is difficult to quantify. We studied the transmission of HCV infection in stable heterosexual couples: anti-HCV positive patients in hemodialytic therapy and their partners. Thirty-four couples were tested by third generation ELISA and RIBA. Blood samples of anti-HCV positive patients were evaluated by RT-PCR and detected sequences were genotyped by restriction fragment length polymorphism. Concordance of infection was observed in only one couple in which both subjects were in dialytic therapy. One other partner had two positive ELISA tests and an indeterminate RIBA, with negative RT-PCR, which may suggest a false positive or a previous resolved infection. Either sexual relations, sharing of personal items and history of parenteral exposure (hemodialysis, blood transfusion) could explain transmission in the only couple with concordant infection. We observed, in accordance with previous reports, that this risk is minimal or negligible in stable heterosexual couples. |
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Limited evidence of HCV transmission in stable heterosexual couples from Bahia, BrazilHepatitis Crenal dialysissexual partnerssexually transmitted diseasesHCV infected patients frequently ask their physician about the risk of transmission to their partners. Although it is easy to answer that the risk does exist, it is difficult to quantify. We studied the transmission of HCV infection in stable heterosexual couples: anti-HCV positive patients in hemodialytic therapy and their partners. Thirty-four couples were tested by third generation ELISA and RIBA. Blood samples of anti-HCV positive patients were evaluated by RT-PCR and detected sequences were genotyped by restriction fragment length polymorphism. Concordance of infection was observed in only one couple in which both subjects were in dialytic therapy. One other partner had two positive ELISA tests and an indeterminate RIBA, with negative RT-PCR, which may suggest a false positive or a previous resolved infection. Either sexual relations, sharing of personal items and history of parenteral exposure (hemodialysis, blood transfusion) could explain transmission in the only couple with concordant infection. We observed, in accordance with previous reports, that this risk is minimal or negligible in stable heterosexual couples.Brazilian Society of Infectious Diseases2009-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400004Brazilian Journal of Infectious Diseases v.13 n.4 2009reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702009000400004info:eu-repo/semantics/openAccessBessa,MárciaRodart,Itatiana FerreiraMenezes,Gisele Barreto LopesCarmo,Theomira Mauadi de AzevedoAthanazio,Daniel A.Reis,Mitermayer G.eng2010-03-04T00:00:00Zoai:scielo:S1413-86702009000400004Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2010-03-04T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil |
title |
Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil |
spellingShingle |
Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil Bessa,Márcia Hepatitis C renal dialysis sexual partners sexually transmitted diseases |
title_short |
Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil |
title_full |
Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil |
title_fullStr |
Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil |
title_full_unstemmed |
Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil |
title_sort |
Limited evidence of HCV transmission in stable heterosexual couples from Bahia, Brazil |
author |
Bessa,Márcia |
author_facet |
Bessa,Márcia Rodart,Itatiana Ferreira Menezes,Gisele Barreto Lopes Carmo,Theomira Mauadi de Azevedo Athanazio,Daniel A. Reis,Mitermayer G. |
author_role |
author |
author2 |
Rodart,Itatiana Ferreira Menezes,Gisele Barreto Lopes Carmo,Theomira Mauadi de Azevedo Athanazio,Daniel A. Reis,Mitermayer G. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Bessa,Márcia Rodart,Itatiana Ferreira Menezes,Gisele Barreto Lopes Carmo,Theomira Mauadi de Azevedo Athanazio,Daniel A. Reis,Mitermayer G. |
dc.subject.por.fl_str_mv |
Hepatitis C renal dialysis sexual partners sexually transmitted diseases |
topic |
Hepatitis C renal dialysis sexual partners sexually transmitted diseases |
description |
HCV infected patients frequently ask their physician about the risk of transmission to their partners. Although it is easy to answer that the risk does exist, it is difficult to quantify. We studied the transmission of HCV infection in stable heterosexual couples: anti-HCV positive patients in hemodialytic therapy and their partners. Thirty-four couples were tested by third generation ELISA and RIBA. Blood samples of anti-HCV positive patients were evaluated by RT-PCR and detected sequences were genotyped by restriction fragment length polymorphism. Concordance of infection was observed in only one couple in which both subjects were in dialytic therapy. One other partner had two positive ELISA tests and an indeterminate RIBA, with negative RT-PCR, which may suggest a false positive or a previous resolved infection. Either sexual relations, sharing of personal items and history of parenteral exposure (hemodialysis, blood transfusion) could explain transmission in the only couple with concordant infection. We observed, in accordance with previous reports, that this risk is minimal or negligible in stable heterosexual couples. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-86702009000400004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.13 n.4 2009 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209241036488704 |