Immune responses to Leptospira infection: roles as biomarkers for disease severity

Detalhes bibliográficos
Autor(a) principal: Chirathaworn,Chintana
Data de Publicação: 2014
Outros Autores: Kongpan,Sutthikarn
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Infectious Diseases
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100077
Resumo: Various leptospiral components have been identified and shown to be involved in tissue destruction. In addition, immune responses to leptospires have been implicated in target organ damages in severe leptospirosis cases. Several inflammatory mediators were shown to be higher in susceptible animals than in resistant hosts. Moreover, cytokines/chemokines and serum proteins induced following Leptospira infection were suggested to be biomarkers for disease severity in human leptospirosis. This review focuses on the role of immune responses in the severity of leptospirosis. Studies in both animal models and humans are discussed.
id BSID-1_a233047da4d01a07bdcee796f63c5d58
oai_identifier_str oai:scielo:S1413-86702014000100077
network_acronym_str BSID-1
network_name_str Brazilian Journal of Infectious Diseases
repository_id_str
spelling Immune responses to Leptospira infection: roles as biomarkers for disease severityLeptospirosisSeverityBiomarkerImmune responseVarious leptospiral components have been identified and shown to be involved in tissue destruction. In addition, immune responses to leptospires have been implicated in target organ damages in severe leptospirosis cases. Several inflammatory mediators were shown to be higher in susceptible animals than in resistant hosts. Moreover, cytokines/chemokines and serum proteins induced following Leptospira infection were suggested to be biomarkers for disease severity in human leptospirosis. This review focuses on the role of immune responses in the severity of leptospirosis. Studies in both animal models and humans are discussed.Brazilian Society of Infectious Diseases2014-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100077Brazilian Journal of Infectious Diseases v.18 n.1 2014reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1016/j.bjid.2013.08.002info:eu-repo/semantics/openAccessChirathaworn,ChintanaKongpan,Sutthikarneng2015-08-28T00:00:00Zoai:scielo:S1413-86702014000100077Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2015-08-28T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false
dc.title.none.fl_str_mv Immune responses to Leptospira infection: roles as biomarkers for disease severity
title Immune responses to Leptospira infection: roles as biomarkers for disease severity
spellingShingle Immune responses to Leptospira infection: roles as biomarkers for disease severity
Chirathaworn,Chintana
Leptospirosis
Severity
Biomarker
Immune response
title_short Immune responses to Leptospira infection: roles as biomarkers for disease severity
title_full Immune responses to Leptospira infection: roles as biomarkers for disease severity
title_fullStr Immune responses to Leptospira infection: roles as biomarkers for disease severity
title_full_unstemmed Immune responses to Leptospira infection: roles as biomarkers for disease severity
title_sort Immune responses to Leptospira infection: roles as biomarkers for disease severity
author Chirathaworn,Chintana
author_facet Chirathaworn,Chintana
Kongpan,Sutthikarn
author_role author
author2 Kongpan,Sutthikarn
author2_role author
dc.contributor.author.fl_str_mv Chirathaworn,Chintana
Kongpan,Sutthikarn
dc.subject.por.fl_str_mv Leptospirosis
Severity
Biomarker
Immune response
topic Leptospirosis
Severity
Biomarker
Immune response
description Various leptospiral components have been identified and shown to be involved in tissue destruction. In addition, immune responses to leptospires have been implicated in target organ damages in severe leptospirosis cases. Several inflammatory mediators were shown to be higher in susceptible animals than in resistant hosts. Moreover, cytokines/chemokines and serum proteins induced following Leptospira infection were suggested to be biomarkers for disease severity in human leptospirosis. This review focuses on the role of immune responses in the severity of leptospirosis. Studies in both animal models and humans are discussed.
publishDate 2014
dc.date.none.fl_str_mv 2014-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100077
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100077
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.bjid.2013.08.002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
publisher.none.fl_str_mv Brazilian Society of Infectious Diseases
dc.source.none.fl_str_mv Brazilian Journal of Infectious Diseases v.18 n.1 2014
reponame:Brazilian Journal of Infectious Diseases
instname:Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
instname_str Brazilian Society of Infectious Diseases (BSID)
instacron_str BSID
institution BSID
reponame_str Brazilian Journal of Infectious Diseases
collection Brazilian Journal of Infectious Diseases
repository.name.fl_str_mv Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)
repository.mail.fl_str_mv bjid@bjid.org.br||lgoldani@ufrgs.br
_version_ 1754209242824310784

Registros relacionados