B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity

Detalhes bibliográficos
Autor(a) principal: Malheiro, Filipa
Data de Publicação: 2024
Outros Autores: Ângelo-Dias, Miguel, Lopes, Teresa, Azeredo-Lopes, Sofia, Martins, Catarina, Borrego, Luis Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/163806
Resumo: Funding Information: This research was funded by the Learning Health Hospital da Luz. LH.INV.F2019002. Publisher Copyright: © 2024 by the authors.
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spelling B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severityacute pancreatitisB cellbiomarkerlymphocyteprognosisseverityT cellMedicine(all)Funding Information: This research was funded by the Learning Health Hospital da Luz. LH.INV.F2019002. Publisher Copyright: © 2024 by the authors.Acute pancreatitis (AP) is an increasingly frequent disease in which inflammation plays a crucial role. Fifty patients hospitalized with AP were included and peripheral blood samples were analyzed for B and T cell subpopulations at the time of hospitalization and 48 h after diagnosis. The Bedside Index of Severity in Acute Pancreatitis (BISAP) and length of hospital stay were also recorded. A healthy control (HC) group of 15 outpatients was included. AP patients showed higher neutrophil/lymphocyte (N/L) ratios and higher percentages of B cells than the HC group. The total B cell percentages were higher in patients with moderate/severe AP than in patients with mild AP. The percentages of B cells as well as the percentages of the CD27−IgD− B cell subset decreased from admission to 48 h after admission. The patients with higher BISAP scores showed lower percentages of peripheral lymphocytes but higher percentages of CD27−IgD− B cells. Higher BISAP scores, N/L ratios, and peripheral blood B cell levels emerged as predictors of hospital stay length in AP patients. Our findings underscore the importance of early markers for disease severity. Additionally, the N/L ratio along with the BISAP score and circulating B cell levels form a robust predictive model for hospital stay duration of AP patients.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNMalheiro, FilipaÂngelo-Dias, MiguelLopes, TeresaAzeredo-Lopes, SofiaMartins, CatarinaBorrego, Luis Miguel2024-02-19T23:52:06Z2024-012024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/163806eng2079-9721PURE: 83168409https://doi.org/10.3390/diseases12010018info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:18:37Zoai:run.unl.pt:10362/163806Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:18:37Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity
title B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity
spellingShingle B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity
Malheiro, Filipa
acute pancreatitis
B cell
biomarker
lymphocyte
prognosis
severity
T cell
Medicine(all)
title_short B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity
title_full B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity
title_fullStr B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity
title_full_unstemmed B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity
title_sort B Cells and Double-Negative B Cells (CD27−IgD−) Are Related to Acute Pancreatitis Severity
author Malheiro, Filipa
author_facet Malheiro, Filipa
Ângelo-Dias, Miguel
Lopes, Teresa
Azeredo-Lopes, Sofia
Martins, Catarina
Borrego, Luis Miguel
author_role author
author2 Ângelo-Dias, Miguel
Lopes, Teresa
Azeredo-Lopes, Sofia
Martins, Catarina
Borrego, Luis Miguel
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Malheiro, Filipa
Ângelo-Dias, Miguel
Lopes, Teresa
Azeredo-Lopes, Sofia
Martins, Catarina
Borrego, Luis Miguel
dc.subject.por.fl_str_mv acute pancreatitis
B cell
biomarker
lymphocyte
prognosis
severity
T cell
Medicine(all)
topic acute pancreatitis
B cell
biomarker
lymphocyte
prognosis
severity
T cell
Medicine(all)
description Funding Information: This research was funded by the Learning Health Hospital da Luz. LH.INV.F2019002. Publisher Copyright: © 2024 by the authors.
publishDate 2024
dc.date.none.fl_str_mv 2024-02-19T23:52:06Z
2024-01
2024-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/163806
url http://hdl.handle.net/10362/163806
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2079-9721
PURE: 83168409
https://doi.org/10.3390/diseases12010018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817545988373479424

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