An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Infectious Diseases |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400006 |
Resumo: | We studied an outbreak of two multi-drug resistant clones of Acinetobacter baumannii in the Neonatal Intensive Care Unit of the Uberlândia Federal University Hospital in Minas Gerais state, Brazil, and we analyzed the contribution of cross-transmission in the rise in infection rates. Eleven neonates who developed multi-drug resistant A. baumannii nosocomial infection were matched to 22 neonates who were admitted to the same unit and did not develop an infection during the outbreak period, in order to identify risk factors for infection. Three out of the 11 neonates died. Epidemiological investigation included molecular typing, using pulsed field gel electrophoresis. Prior to the outbreak, from December 2001 to March 2002, no case of infection by this microorganism was diagnosed. Environmental and healthcare worker hand cultures were negative. Nine isolates had similar pulsed field gel electrophoresis patterns and two had another clone. The first clone was brought into the unit by an infected patient who was transferred from another hospital without a history of antibiotic use. The second clone did have its origin clearly defined. Both infected groups led us to conclude that several factors contributed to infection with A. baumannii. These factors were: exposure to antibiotics and invasive devices, birth weight < 1500g, age < 7 days and duration of hospitalization > 7 days. Based on logistic regression, infected neonates were more exposed to carbapenem and mechanical ventilation than the control group. Cross transmission between infants contributed to the rise in the rates of multi-drug resistant A. baumannii infection. |
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An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in BrazilAcinetobacter baumanniimolecular epidemiologyoutbreakneonatesWe studied an outbreak of two multi-drug resistant clones of Acinetobacter baumannii in the Neonatal Intensive Care Unit of the Uberlândia Federal University Hospital in Minas Gerais state, Brazil, and we analyzed the contribution of cross-transmission in the rise in infection rates. Eleven neonates who developed multi-drug resistant A. baumannii nosocomial infection were matched to 22 neonates who were admitted to the same unit and did not develop an infection during the outbreak period, in order to identify risk factors for infection. Three out of the 11 neonates died. Epidemiological investigation included molecular typing, using pulsed field gel electrophoresis. Prior to the outbreak, from December 2001 to March 2002, no case of infection by this microorganism was diagnosed. Environmental and healthcare worker hand cultures were negative. Nine isolates had similar pulsed field gel electrophoresis patterns and two had another clone. The first clone was brought into the unit by an infected patient who was transferred from another hospital without a history of antibiotic use. The second clone did have its origin clearly defined. Both infected groups led us to conclude that several factors contributed to infection with A. baumannii. These factors were: exposure to antibiotics and invasive devices, birth weight < 1500g, age < 7 days and duration of hospitalization > 7 days. Based on logistic regression, infected neonates were more exposed to carbapenem and mechanical ventilation than the control group. Cross transmission between infants contributed to the rise in the rates of multi-drug resistant A. baumannii infection.Brazilian Society of Infectious Diseases2005-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400006Brazilian Journal of Infectious Diseases v.9 n.4 2005reponame:Brazilian Journal of Infectious Diseasesinstname:Brazilian Society of Infectious Diseases (BSID)instacron:BSID10.1590/S1413-86702005000400006info:eu-repo/semantics/openAccessBrito,Denise von Dolinger deOliveira,Elias JoséAbdallah,Vânia O. SteffenDarini,Ana Lúcia da CostaGontijo Filho,Paulo P.eng2005-11-01T00:00:00Zoai:scielo:S1413-86702005000400006Revistahttps://www.bjid.org.br/https://old.scielo.br/oai/scielo-oai.phpbjid@bjid.org.br||lgoldani@ufrgs.br1678-43911413-8670opendoar:2005-11-01T00:00Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID)false |
dc.title.none.fl_str_mv |
An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in Brazil |
title |
An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in Brazil |
spellingShingle |
An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in Brazil Brito,Denise von Dolinger de Acinetobacter baumannii molecular epidemiology outbreak neonates |
title_short |
An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in Brazil |
title_full |
An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in Brazil |
title_fullStr |
An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in Brazil |
title_full_unstemmed |
An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in Brazil |
title_sort |
An outbreak of Acinetobacter baumannii septicemia in a neonatal intensive care unit of a university hospital in Brazil |
author |
Brito,Denise von Dolinger de |
author_facet |
Brito,Denise von Dolinger de Oliveira,Elias José Abdallah,Vânia O. Steffen Darini,Ana Lúcia da Costa Gontijo Filho,Paulo P. |
author_role |
author |
author2 |
Oliveira,Elias José Abdallah,Vânia O. Steffen Darini,Ana Lúcia da Costa Gontijo Filho,Paulo P. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Brito,Denise von Dolinger de Oliveira,Elias José Abdallah,Vânia O. Steffen Darini,Ana Lúcia da Costa Gontijo Filho,Paulo P. |
dc.subject.por.fl_str_mv |
Acinetobacter baumannii molecular epidemiology outbreak neonates |
topic |
Acinetobacter baumannii molecular epidemiology outbreak neonates |
description |
We studied an outbreak of two multi-drug resistant clones of Acinetobacter baumannii in the Neonatal Intensive Care Unit of the Uberlândia Federal University Hospital in Minas Gerais state, Brazil, and we analyzed the contribution of cross-transmission in the rise in infection rates. Eleven neonates who developed multi-drug resistant A. baumannii nosocomial infection were matched to 22 neonates who were admitted to the same unit and did not develop an infection during the outbreak period, in order to identify risk factors for infection. Three out of the 11 neonates died. Epidemiological investigation included molecular typing, using pulsed field gel electrophoresis. Prior to the outbreak, from December 2001 to March 2002, no case of infection by this microorganism was diagnosed. Environmental and healthcare worker hand cultures were negative. Nine isolates had similar pulsed field gel electrophoresis patterns and two had another clone. The first clone was brought into the unit by an infected patient who was transferred from another hospital without a history of antibiotic use. The second clone did have its origin clearly defined. Both infected groups led us to conclude that several factors contributed to infection with A. baumannii. These factors were: exposure to antibiotics and invasive devices, birth weight < 1500g, age < 7 days and duration of hospitalization > 7 days. Based on logistic regression, infected neonates were more exposed to carbapenem and mechanical ventilation than the control group. Cross transmission between infants contributed to the rise in the rates of multi-drug resistant A. baumannii infection. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-08-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1413-86702005000400006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Society of Infectious Diseases |
dc.source.none.fl_str_mv |
Brazilian Journal of Infectious Diseases v.9 n.4 2005 reponame:Brazilian Journal of Infectious Diseases instname:Brazilian Society of Infectious Diseases (BSID) instacron:BSID |
instname_str |
Brazilian Society of Infectious Diseases (BSID) |
instacron_str |
BSID |
institution |
BSID |
reponame_str |
Brazilian Journal of Infectious Diseases |
collection |
Brazilian Journal of Infectious Diseases |
repository.name.fl_str_mv |
Brazilian Journal of Infectious Diseases - Brazilian Society of Infectious Diseases (BSID) |
repository.mail.fl_str_mv |
bjid@bjid.org.br||lgoldani@ufrgs.br |
_version_ |
1754209239056777216 |